Parallel increases in phosphocreatine and total creatine in human vastus lateralis muscle during creatine supplementation

International Journal of Sport Nutrition and Exercise Metabolism

Volumn 17, Issue 6, 2007, Pages 624-634

  Brault, Jeffrey J ^a   Towse, Theodore F ^a   Slade, Jill M ^b   Meyer, Ronald A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

Creatine kinase; Energetics; Magnetic resonance spectroscopy

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CREATINE; CREATINE PHOSPHATE;

ADULT; ARTICLE; BLOOD LEVEL; CYTOPLASM; DIET SUPPLEMENTATION; ENERGY; ENZYME ACTIVITY; ERYTHROCYTE; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; MALE; NORMAL HUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; VASTUS LATERALIS MUSCLE;

EID: 37549057986     PISSN: 1526484X     EISSN: 15432742     Source Type: Journal    
DOI: 10.1123/ijsnem.17.6.624     Document Type: Article

References (41)

1. Abraham, K.A., J.J. Brault, and R.L. Terjung. Phosphate uptake and PiT-1 protein expression in rat skeletal muscle. Am. J. Physiol. Cell Physiol. 287:C73-C78, 2004.
2. Bemben, M.G., and H.S. Lamont. Creatine supplementation and exercise performance: recent findings. Sports Med. 35:107-125, 2005.
3. Brannon, T.A., G.R. Adams, C.L. Conniff, and K.M. Baldwin. Effects of creatine loading and training on running performance and biochemical properties of rat skeletal muscle. Med. Sci. Sports Exerc. 29:489-495, 1997.
4. Brault, J.J., K.A. Abraham, and R.L. Terjung. Phosphocreatine content of freezeclamped muscle: influence of creatine kinase inhibition. J. Appl. Physiol. 94:1751-1756, 2003.
5. Brault, J.J., and R.L. Terjung. Creatine uptake and creatine transporter expression among rat skeletal muscle fiber types. Am. J. Physiol., Cell Physiol. 284:C1481-C1489, 2003.
6. Chilibeck, P.D., D. Stride, J.P. Farthing, and D.G. Burke. Effect of creatine ingestion after exercise on muscle thickness in males and females. Med. Sci. Sports Exerc. 36:1781-1788, 2004.
7. Crim, M.C., D.H. Calloway, and S. Margen. Creatine metabolism in men: urinary creatine and creatinine excretions with creatine feeding. J. Nutr. 105:428-438, 1975.
8. Eijnde, B.O., W. Derave, J.F. Wojtaszewski, E.A. Richter, and P. Hespel. AMP kinase expression and activity in human skeletal muscle: effects of immobilization, retraining, and creatine supplementation. J. Appl. Physiol. 98:1228-1233, 2005.
9. Eijnde, B.O., J. Lebacq, M. Ramaekers, and P. Hespel. Effect of muscle creatine content manipulation on contractile properties in mouse muscles. Muscle Nerve. 29:428-435, 2004.
10. Febbraio, M.A., T.R. Flanagan, R.J. Snow, S. Zhao, and M.F. Carey. Effect of creatine supplementation on intramuscular TCr, metabolism and performance during intermittent, supramaximal exercise in humans. Acta Physiol. Scand. 155:387-395, 1995.
11. Green, A.L., E. Hultman, I.A. Macdonald, D.A. Sewell, and P.L. Greenhaff. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am. J. Physiol. 271:E821-E826, 1996.
12. Greenhaff, P.L., K. Bodin, K. Soderlund, and E. Hultman. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am. J. Physiol. 266: E725-E730, 1994.
13. Harkema, S.J., and R.A. Meyer. Effect of acidosis on control of respiration in skeletal muscle. Am. J. Physiol. 272:C491-C500, 1997.
14. Harris, R.C., K. Soderlund, and E. Hultman. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. (Lond.). 83:367-374, 1992.
15. Hultman, E., K. Soderlund, J.A. Timmons, G. Cederblad, and P.L. Greenhaff. Muscle creatine loading in men. J. Appl. Physiol. 81:232-237, 1996.
16. Ipsiroglu, O.S., C. Stromberger, J. Ilas, H. Hoger, A. Muhl, and S. Stockler-Ipsiroglu. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci. 69:1805-1815, 2001.
17. Kan, H.E., M. van der Graaf, D.W. Klomp, M.H. Vlak, G.W. Padberg, and A. Heerschap. Intake of 13C-4 creatine enables simultaneous assessment of creatine and phosphocreatine pools in human skeletal muscle by 13C MR spectroscopy. Magn. Reson. Med. 56:953-957, 2006.
18. Kemp, G.J., M. Meyerspeer, and E. Moser. Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by (31)P MRS: a quantitative review. NMR Biomed. 20:555-565, 2007.
19. Kreider, R.B. Effects of creatine supplementation on performance and training adaptations. Mol. Cell. Biochem. 244:89-94, 2003.
20. Kreis, R., M. Kamber, M. Koster, et al. Creatine supplementation - part II: in vivo magnetic resonance spectroscopy. Med. Sci. Sports Exerc. 31:1770-1777, 1999.
21. Lawson, J.W., and R.L. Veech. Effects of pH and free Mg2+ on the Keq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions. J. Biol. Chem. 254:6528-6537, 1979.
22. McKenna, M.J., J. Morton, S.E. Selig, and R.J. Snow. Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance. J. Appl. Physiol. 87:2244-2252, 1999.
23. McMillen, J., C.M. Donovan, J.I. Messer, and W.T. Willis. Energetic driving forces are maintained in resting rat skeletal muscle after dietary creatine supplementation. J. Appl. Physiol. 90:62-66, 2001.
24. Meyer, R.A., T.R. Brown, and M.J. Kushmerick. Phosphorus nuclear magnetic resonance of fast- and slow-twitch muscle. Am. J. Physiol. 248:C279-C287, 1985.
25. Meyer, R.A., M.J. Kuchmerick, and T.R. Brown. Application of 31P-NMR spectroscopy to the study of striated muscle metabolism. Am. J. Physiol. 242:C1-C11, 1982.
26. Murphy, R.M., D.G. Stephenson, and G.D. Lamb. Effect of creatine on contractile force and sensitivity in mechanically skinned single fibers from rat skeletal muscle. Am. J. Physiol., Cell Physiol. 287:C1589-C1595, 2004.
27. Op 't Eijnde, B., E.A. Richter, J.C. Henquin, B. Kiens, and P. Hespel. Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle. Acta Physiol. Scand. 171:169-176, 2001.
28. Persky, A.M., G.A. Brazeau, and G. Hochhaus. Pharmacokinetics of the dietary supplement creatine. Clin. Pharmacokinet. 42:557-574, 2003.
29. Preen, D.B., B.T. Dawson, C. Goodman, J. Beilby, and S. Ching. Comparison of erythrocyte and skeletal muscle creatine accumulation following creatine loading. Int. J. Sport Nutr. Exerc. Metab. 15:84-93, 2005.
30. Sharma, U., S. Atri, M.C. Sharma, C. Sarkar, and N.R. Jagannathan. Skeletal muscle metabolism in Duchenne muscular dystrophy (DMD): an in-vitro proton NMR spectroscopy study. Magn. Reson. Imaging. 21:145-153, 2003.
31. Sjogaard, G., and B. Saltin. Extra- and intracellular water spaces in muscles of man at rest and with dynamic exercise. Am. J. Physiol. 243:R271-R280, 1982.
32. Slade, J.M., M.C. Delano, and R.A. Meyer. Elevated skeletal muscle phosphodiesters in adults using statin medications. Muscle Nerve. 34:782-784, 2006.
33. Snow, R.J., and R.M. Murphy. Factors influencing creatine loading into human skeletal muscle. Exerc. Sport Sci. Rev. 31:154-158, 2003.
34. Soderlund, K., and E. Hultman. Effects of delayed freezing on content of phosphagens in human skeletal muscle biopsy samples. J. Appl. Physiol. 61:832-835, 1986.
35. Stephens, F.B., D. Constantin-Teodosiu, and P.L. Greenhaff. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J. Physiol. 581:431-444, 2007.
36. Terjung, R.L., P. Clarkson, E.R. Eichner, et al. American College of Sports Medicine roundtable. the physiological and health effects of oral creatine supplementation. Med. Sci. Sports Exerc. 32:706-717, 2000.
37. Trump, M.E., C.C. Hanstock, P.S. Allen, D. Gheorghiu, and P.W. Hochachka. An (1)HMRS evaluation of the phosphocreatine/creatine pool (tCr) in human muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280:R889-R896, 2001.
38. Watt, K.K., A.P. Garnham, and R.J. Snow. Skeletal muscle total creatine content and creatine transporter gene expression in vegetarians prior to and following creatine supplementation. Int. J. Sport Nutr. Exerc. Metab. 14:517-531, 2004.
39. Wiseman, R.W., T.S. Moerland, P.B. Chase, R. Stuppard, and M.J. Kushmerick. Highperformance liquid chromatographic assays for free and phosphorylated derivatives of the creatine analogues beta-guanidopropionic acid and 1-carboxy-methyl-2-iminoimidazolidine (cyclocreatine). Anal. Biochem. 204:383-389, 1992.
40. Wixom, R.L., G.E. Davis, M.A. Flynn, R.T. Tsutakawa, and D.J. Hentges. Excretion of creatine and creatinine in feces of man. Proc. Soc. Exp. Biol. Med. 161:452-457, 1979.
41. Ziegenfuss, T.N., M. Rogers, L. Lowery, N. Mullins, R. Mendel, J. Antonio, and P. Lemon. Effect of creatine loading on anaerobic performance and skeletal muscle volume in NCAA Division I athletes. Nutrition. 18:397-402, 2002.