Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 375-379

  Sparey, Tim ^a   Clarke, Earl ^a   Hannam, Joanne ^a   Harrison, Timothy ^a   Madin, Andrew ^a   Shearman, Mark ^a   Sohal, Bindi ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Secretase inhibitor; Alzheimer's disease

Indexed keywords

BICYCLO COMPOUND; BICYCLO[4.2.1]NONANE DERIVATIVE; BRIDGED COMPOUND; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BAEYER VILLIGER REACTION; CYCLIZATION; DRUG ABSORPTION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; NONHUMAN; PORTAL VEIN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ALKANES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BICYCLO COMPOUNDS; CELL LINE, TUMOR; HUMANS; PORTAL VEIN; PROTEASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

RATTUS;

EID: 37549057632     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.057     Document Type: Article

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