Expression of the HPV11 E2 gene in transgenic mice does not result in alterations of the phenotypic pattern

Transgenic Research

Volumn 17, Issue 1, 2008, Pages 1-8

  Leykauf, Kerstin ^a   Kabsch, Kirsten ^a   Gassler, Nikolaus ^b   Gissmann, Lutz ^a   Alonso, Angel ^a   Schenkel, Johannes ^a,c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Animal model; E2 protein; Papillomavirus; Skin; Transgenic mice; Ubiquitin C promoter

Indexed keywords

E2 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 11; MESSENGER RNA; PRIMER DNA; RECOMBINANT PROTEIN; UBIQUITIN C; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ANIMAL; ARTICLE; C57BL MOUSE; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 11; MALE; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PATHOLOGY; PHENOTYPE; PROMOTER REGION; SKIN; TRANSGENIC MOUSE; VIROLOGY; VIRUS GENE;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FEMALE; GENE EXPRESSION; GENES, VIRAL; HUMAN PAPILLOMAVIRUS 11; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, VIRAL; SKIN; UBIQUITIN C; VIRAL PROTEINS;

ANIMALIA; HUMAN PAPILLOMAVIRUS TYPE 11; MUS; MUS MUSCULUS; PAPILLOMAVIRIDAE;

EID: 37549048664     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-007-9130-y     Document Type: Article

References (37)

1. Arbeit JM, Howley PM, Hanahan D (1996) Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. Proc Natl Acad Sci USA 93:2930-2935
2. Baker CC, Phelps WC, Lindgren V, Braun MJ, Gonda MA, Howley PM (1987) Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol 61:962-971
3. Bellanger S, Demeret C, Goyat S, Thierry F (2001) Stability of the human papillomavirus type 18 E2 protein is regulated by a proteasome degradation pathway through its amino-terminal transactivation domain. J Virol 75:7244-7251
4. Bellanger S, Blachon S, Mechali F, Bonne-Andrea C, Thierry F (2005) High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability. Cell Cycle 4:1608-1615
5. Blachon S, Demeret C (2003) The regulatory E2 proteins of human genital papillomaviruses are pro-apoptotic. Biochimie 85:813-819
6. Blachon S, Bellanger S, Demeret C, Thierry F (2005) Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis. J Biol Chem 280:36088-36098
7. Bravo IG, Muller M (2005) Codon usage in papillomavirus genes: practical and functional aspects. Papillomavirus Rep 16:63-70
8. Chao SF, Rocque WJ, Daniel S, Czyzyk LE, Phelps WC, Alexander KA (1999) Subunit affinities and stoichiometries of the human papillomavirus type 11 E1:E2:DNA complex. Biochemistry 38:4586-4594
9. Corden SA, Sant-Cassia LJ, Easton AJ, Morris AG (1999) The integration of HPV-18 DNA in cervical carcinoma. Mol Pathol 52:275-282
10. Dao LD, Duffy A, Van Tine BA, Wu SY, Chiang CM, Broker TR, Chow LT (2006) Dynamic localization of the human papillomavirus type 11 origin binding protein E2 through mitosis while in association with the spindle apparatus. J Virol 80:4792-4800
11. Demeret C, Garcia-Carranca A, Thierry F (2003) Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein. Oncogene 22:168-175
12. Desaintes C, Demeret C (1996) Control of papillomavirus DNA replication and transcription. Semin Cancer Biol 7:339-347
13. Dong G, Broker TR, Chow LT (1994) Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements. J Virol 68:1115-1127
14. Eckert RL, Crish JF, Balasubramanian S, Rorke EA (2000) Transgenic animal models of human papillomavirus-dependent disease (Review). Int J Oncol 16(5):853-870
15. Hadaschik D, Hinterkeuser K, Oldak M, Pfister HJ, Smola-Hess S (2003) The Papillomavirus E2 protein binds to and synergizes with C/EBP factors involved in keratinocyte differentiation. J Virol 77(9):5253-5265
16. Hughes AL, Hughes MA (2005) Patterns of nucleotide difference in overlapping and non-overlapping reading frames of papillomavirus genomes. Virus Res 113:81-88
17. Kalantari M, Karlsen F, Kristensen G, Holm R, Hagmar B, Johansson B (1998) Disruption of the E1 and E2 reading frames of HPV 16 in cervical carcinoma is associated with poor prognosis. Int J Gynecol Pathol 17:146-153
18. Leykauf K, Salek M, Bomke J, Frech M, Lehmann WD, Dürst M, Alonso A (2006) Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process. J Cell Sci 119(Pt 17):3634-3642
19. Longworth MS, Laimins LA (2004) Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 68:362-372
20. Marcello A, Massimi P, Banks L, Giacca M (2000) Adeno-associated virus type 2 rep protein inhibits human papillomavirus type 16 E2 recruitment of the transcriptional coactivator p300. J Virol 74:9090-9098
21. McCance DJ (2005) Transcriptional regulation by human papillomaviruses. Curr Opin Genet Dev 15:515-519
22. Nagy A, Gertsenstein M, Vintersten K, Behringer R (2003) Manipulating the mouse embryo. A laboratory manual, 3rd edn. Cold Spring Harbor Press, Cold Spring Harbor, NY
23. Narechania A, Terai M, Burk RD (2005) Overlapping reading frames in closely related human papillomaviruses result in modular rates of selection within E2. J Gen Virol 86:1307-1313
24. Oldak M, Smola H, Aumailley M, Rivero F, Pfister H, Smola-Hess S (2004) The human papillomavirus type 8 E2 protein suppresses beta4-integrin expression in primary human keratinocytes. J Virol 78(19):10738-10746
25. Parish JL, Kowalczyk A, Chen HT, Roeder GE, Sessions R, Buckle M, Gaston K (2006) E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death. J Virol 80:4580-4590
26. Rulli SB, Kuorelahti A, Karaer O, Pelliniemi LJ, Poutanen M, Huhtaniemi I (2002) Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology 143:4084-4095
27. Schaper ID, Marcuzzi GP, Weissenborn SJ, Kasper HU, Dries V, Smyth N, Fuchs P, Pfister H (2005) Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. Cancer Res 65:1394-1400
28. Schenkel J, Gaissert H, Protopapa EE, Weiher H, Gissmann L, Alonso A (1999) The human papillomavirus type 11 upstream regulatory region triggers hair-follicle-specific gene expression in transgenic mice. J Invest Dermatol 112:893-898
29. Schorpp M, Jager R, Schellander K, Schenkel J, Wagner EF, Weiher H, Angel P (1996) The human Ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res 24:1787-1788
30. Sethi N, Palefsky J (2004) Transcriptional profiling of dysplastic lesions in K14-HPV16 transgenic mice using laser microdissection. FASEB J 18:1243-1245
31. Stubenrauch F, Colbert AM, Laimins LA (1998) Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions. J Virol 72:8115-8123
32. Tan SH, Gloss B, Bernard HU (1992) During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element. Nucleic Acids Res 20:251-256
33. Van Tine BA, Dao LD, Wu SY, Sonbuchner TM, Lin BY, Zou N, Chiang CM, Broker TR, Chow LT (2004) Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning. Proc Natl Acad Sci USA 101(12):4030-4035
34. White PW, Titolo S, Brault K, Thauvette L, Pelletier A, Welchner E, Bourgon L, Doyon L, Ogilvie WW, Yoakim C, Cordingley MG, Archambault J (2003) Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction. J Biol Chem 278:26765-26772
35. Winter C, Weiss C, Martin-Villalba A, Zimmermann M, Schenkel J (2002) JunB and Bcl-2 overexpression results in protection against cell death of nigral neurons. Brain Res Mol Brain Res 104:194-202
36. Yu T, Peng YC, Androphy EJ (2007) Mitotic kinesin-like protein 2 binds and colocalizes with papillomavirus E2 during mitosis. J Virol 81(4):1736-1745
37. zur Hausen H, de Villiers EM (1994) Human papillomaviruses. Annu Rev Microbiol 48:427-447