Resistance of the female, as opposed to the male, intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury

Shock

Volumn 29, Issue 1, 2008, Pages 78-83

  Deitch, Edwin A ^a   Feketeova, Eleonora ^a   Lu, Qi ^a   Zaets, Sergy ^a   Berezina, Tamara L ^a   MacHiedo, George W ^a   Hauser, Carl J ^a   Livingston, David H ^a   Xu, Da Zhong ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Bone marrow dysfunction; Lung injury; RBC dysfunction; Sex; Superior mesenteric artery occlusion

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE INJURY; BONE MARROW DEPRESSION; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; INTESTINE ISCHEMIA; LEUKOCYTE; LEUKOCYTE ACTIVATION; LUNG INJURY; MALE; NEUTROPHIL; NONHUMAN; ORGAN INJURY; PROESTRUS; RAT; REPERFUSION INJURY; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; SUPERIOR MESENTERIC ARTERY OBSTRUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; ERYTHROCYTE DEFORMABILITY; FEMALE; INTESTINES; LIGATION; MALE; MESENTERIC ARTERY, SUPERIOR; MULTIPLE ORGAN FAILURE; NEUTROPHILS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RESPIRATORY BURST; SEX CHARACTERISTICS;

EID: 37549043869     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/shk.0b013e318063e98a     Document Type: Article

References (35)

1. Deitch EA: Role of the gut lymphatic system in multiple organ failure. Curr Opin Crit Care 7:92-98, 2001.
2. Deitch EA, Adams CA, Lu Q, Xu DZ: A time course study of the protective effect of mesenteric lymph duct ligation on hemorrhagic shock-induced pulmonary injury and the toxic effects of lymph from shocked rats on endothelial cell monolayer permeability. Surgery 129:39-47, 2001.
3. Adams JM, Hauser CJ, Adams JM, Xu DZ, Livingston DH, Deitch EA: Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. Crit Care Med 29:2194-2198, 2001.
4. Machiedo GW, Zeats S, Berezina T, Xu DZ, Spolarics Z, Deitch EA: Red blood cell damage after trauma-hemorrhage is modulated by gender. J Trauma 56:837-844, 2004.
5. Anjaria DJ, Rameshwar P, Deitch EA, Xu DZ, Adams CA, Livingston DH: Hematopoietic failure after hemorrhagic shock is mediated partially through mesenteric lymph. Crit Care Med 29:1780-1785, 2001.
6. Magnotti LJ, Xu DZ, Lu Q, Deitch EA: Gut-derived mesenteric lymph: a link between burn and lung injury. Arch Surg 134:1333-1341, 1999.
7. Deitch EA, Forsythe R, Anjaria D, Livingston DH, Lu Q, Xu DZ, Redl H: The role of lymph factors in lung injury, bone marrow suppression and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock. Shock 22:221-228, 2004.
8. Sarin EL, Moore EE, Moore JB, Masuno T, Moore JL, Banerjee A, Silliman CC: Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species. J Trauma 57:950-954, 2004.
9. Adams CA, Magnotti LJ, Xu DZ, Lu Q, Deitch EA: Acute lung injury after hemorrhagic shock is dependent on gut injury and gender. Am Surg 66:905-913, 2000.
10. Caruso JM, Deitch EA, Xu DZ, Lu Q, Dayal SD: Gut injury and gut-induced lung injury after trauma-hemorrhagic shock is gender and estrus cycle specific in the rat. J Trauma 55:531-539, 2003.
11. Ba ZF, Yokoyama Y, Toth B, Rue LW, Bland KI, Chaudry IH: Gender differences in small intestinal endothelial function: inhibitory role of androgens. Am J Physiol Gastrointest Liver Physiol 286:G452-G457, 2004.
12. Ba ZF, Kuebler JF, Rue LW, Bland KI, Wang P, Chaudry IH: Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function. Am J Physiol Heart Circ Physiol 284:H2162-H2169, 2003.
13. Homma H, Hoy E, Xu DZ, Lu Q, Feinman R, Deitch EA: The female intestine is more resistant than the male intestine to gut injury and inflammation when subjected to conditions associated with shock states. Am J Physiol Gastrointest Liver Physiol 288:G466-G472, 2005.
14. Baker DEJ: Reproduction and breeding. In: Baker HJ, Lindsey JR, Weisbroth SH, eds. The Laboratory Rat. Volume 1: Biology and Diseases. New York, Academic Press, 1979, pp 154-156.
15. Grotz MRW, Ding J, Huang Q, Deitch EA: Comparison of plasma cytokine levels in rats subjected to superior mesenteric artery occlusion or hemorrhagic shock. Shock 3:362-368, 1995.
16. Pries AR, Secomb TW, Gaehtgens P: Design principles of vascular beds. Circ Res 77:1017-1023, 1995.
17. Bessis M: Red cell shapes. An illustrated classification and its rationale. Nouv Rev Franc Hematol 12:721-746, 1972.
18. Ananthakrishnan P, Deitch EA: Gut origin sepsis and MODS: the role of sex hormones in modulating intestinal and distant organ injury. XX vs XY 1:108-117, 2003.
19. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH: Enhanced immune responses in females as opposed to decreased responses in males following hemorrhagic shock and resuscitation. Cytokine 8:853-863, 1996.
20. Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM, Chaudry IH: Females in proestrus state maintain better splenic immune functions and tolerate sepsis better than males. Crit Care Med 25:106-110, 1997.
21. Angele MK, Schwacha MG, Ayala AA, Chaudry IH: Effect of gender and sex hormones on immune responses following shock: a review article. Shock 14:81-90, 2000.
22. Jarrar D, Wang P, Cioffi WG, Bland KI, Chaudry IH: Mechanisms of the salutary effects of dehydroepiandrosterone after trauma-hemorrhage; direct or indirect effects on cardiac and hepatocellular functions? Arch Surg 135:416-423, 2000.
23. Remmers DE, Wang P, Cioffi WG, Bland KI, Chaudry IH: Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. Am J Physiol 273:H2919-H2925, 1997.
24. Ananthakrishnan P, Cohen DB, Xu DZ, Lu Q, Feketeova E, Deitch EA: Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model. Surgery 137:56-65, 2005.
25. Schmeling DJ, Caty MG, Oldham KT: Evidence for neutrophil-related acute lung injury after intestinal ischemia-reperfusion. Surgery 106:195-202, 1989.
26. Gerkin TM, Oldham KT, Guice KS, Hinsshaw DB, Ryan US: Intestinal ischemia-reperfusion injury causes pulmonary endothelial cell ATP depletion. Ann Surg 217:48-56, 1993.
27. Deitch EA: Multiple organ failure: pathophysiology and potential future therapy. Ann Surg 216:117-134, 1992.
28. Ivatory RR, Simon RJ, Islam S, Fueg A, Rohman M, Stahl WM: A prospective, randomized study of end points of resuscitation after major trauma: global oxygen transport indices versus organ-specific gastric mucosal pH. J Am Coll Surg 183:145-154, 1996.
29. Deitch EA: Intestinal permeability is increased in burn patients shortly after injury. Surgery 107:411-416, 1990.
30. Doig CJ, Sutherland LR, Sandham JD, Fick GH, Verhoef M, Meddings JB: Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med 158:444-451, 1998.
31. Goodman ER, Kleinstein E, Fusco AM, Quinlan DP, Lavery R, Livingston DH, Deitch EA, Hauser CJ: Role of interleukin 8 in the genesis of acute respiratory distress syndrome through an effect on neutrophil apoptosis. Arch Surg 133:1234-1239, 1998
32. Patrick DA, Moore FA, Moore EE, Barnett CC, Stilliman CC: Neutrophil priming and activation in the pathogenesis of postinjury multiple organ failure. New Horiz 4:194-210, 1996.
33. Langenfeld J, Livingston DH, Machiedo GW: Red blood cell deformability is an early indicator of infection. Surgery 110:398-403, 1991.
34. Livingston DH, Anjaria D, Wu J, Chang V, Deitch EA: Bone marrow failure following severe injury in humans. Ann Surg 238:748-753, 2003.
35. Moore FA, Sauaia A, Moore EE: Postinjury multiple organ failure: a bimodal phenomenon. J Trauma 40:501-512, 1996.