Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase cepsilon overexpression mice

Toxicologic Pathology

Volumn 35, Issue 7, 2007, Pages 942-951

  Li, Yafan ^a   Wheeler, Deric L ^b   Ananthaswamy, Honnavara N ^c   Verma, Ajit K ^b   Oberley, Terry D ^b,d  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

Author keywords

Cell death; Papilloma; Protein kinase Cepsilon; Squamous cell carcinoma

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; PROTEIN KINASE C EPSILON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INCIDENCE; CARCINOGENESIS; CELL DEATH; CELL INFILTRATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DERMIS; EPIDERMIS; EPIDERMIS CELL; FEMALE; HAIR FOLLICLE; KERATINOCYTE; LATENT PERIOD; MITOSIS; MORPHOLOGY; MOUSE; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TRANSGENIC MOUSE; TUMOR PROMOTION; TUMOR VOLUME;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; FEMALE; GENES, RAS; MICE; MICE, TRANSGENIC; MUTATION; PAPILLOMA; PROTEIN KINASE C-EPSILON; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

MUS;

EID: 37549030215     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230701748164     Document Type: Article

References (14)

1. Balmain, A., and Brown, K. (1988). Oncogene activation in chemical carcinogenesis. Adv Cancer Res 51, 147-82.
2. Balmain, A., Ramsden, M., Bowden, G. T., and Smith, J. (1984). Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature 307, 658-60.
3. Basu, A., Lu, D., Sun, B., Moor, A. N., Akkaraju, G. R., and Huang, J. (2002). Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals. J Biol Chem 277, 41850-6.
4. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. The Journal of Cell Biology 119, 493-501.
5. Jansen, A. P., Verwiebe, E. G., Dreckschmidt, N. E., Wheeler, D. L., Oberley, T. D., and Verma, A. K. (2001). Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. Cancer Res 61, 808-12.
6. Kopp-Schneider, A., and Portier, C. J. (1992). Birth and death/differentiation rates of papillomas in mouse skin. Carcinogenesis 13, 973-8.
7. Li, Y., Wheeler, D. L., Alters, W., Chaiswing, L., Verma, A. K., and Oberley, T. D. (2005). Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice. Toxicol Pathol 33, 684-94.
8. Morris, R. J., Tryson, K. A., and Wu, K. Q. (2000). Evidence that the epidermal targets of carcinogen action are found in the interfollicular epidermis of infundibulum as well as in the hair follicles. Cancer Res 60, 226-9.
9. Nelson, M. A., Futscher, B. W., Kinsella, T., Wymer, J., and Bowden, G. T. (1992). Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors. Proceedings of the National Academy of Sciences of the United States of America 89, 6398-402.
10. Newton, A. C. (2003). Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370, 361-71.
11. Oberley, T. D., Xue, Y., Zhao, Y., Kiningham, K., Szweda, L. I., and St Clair, D. K. (2004). In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model. Antioxid Redox Signal 6, 537-48.
12. Ohno, S., and Nishizuka, Y. (2002). Protein kinase C isotypes and their specific functions: prologue. J Biochem (Tokyo) 132, 509-11.
13. Reddig, P. J., Dreckschmidt, N. E., Zou, J., Bourguignon, S. E., Oberley, T. D., and Verma, A. K. (2000). Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. Cancer Res 60, 595-602.
14. Yuspa, S. H., Hennings, H., and Lichti, U. (1981). Initiator and promoter induced specific changes in epidermal function and biological potential. J Supramol Struct Cell Biochem 17, 245-57.