Enantioselective synthesis of (2R, 3S)- and (2S, 3R)-4,4,4-trifluoro-N- Fmoc-O-tert-butyl-threonine and their racemization-free incorporation into oligopeptides via solid-phase synthesis

Biopolymers - Peptide Science Section

Volumn 88, Issue 6, 2007, Pages 781-796

  Xiao, Nu ^a,b   Jiang, Zhong Xing ^a   Yu, Y Bruce ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

19F NMR; Chiral chromatography; Octreotide; Sharpless AD reaction; Solid phase peptide synthesis; Trifluorothreonine

Indexed keywords

CHIRAL CHROMATOGRAPHY; SOLID-PHASE PEPTIDE SYNTHESIS; TRIFLUOROTHREONINE;

AMINO ACIDS; BIOSYNTHESIS; ENANTIOSELECTIVITY; X RAY CRYSTALLOGRAPHY;

PEPTIDES;

4,4,4 TRIFLUORO N FMOC O TERT BUTYL THREONINE; OLIGOPEPTIDE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; ENANTIOSELECTIVITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RACEMIZATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; FLUORENES; HYDROPHOBICITY; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; OLIGOPEPTIDES; STEREOISOMERISM; THREONINE;

TRIFLUORO;

EID: 37549020739     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20825     Document Type: Article

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