Syntheses and biological activities of sandostatin analogs containing stereochemical changes in positions 6 or 8

Biopolymers

Volumn 53, Issue 6, 2000, Pages 497-505

  Rueter, Jaimie K ^a   Mattern, Ralph Heiko ^a   Zhang, Li ^a   Taylor, John ^b   Morgan, Barry ^b   Hoyer, Daniel ^c   Goodman, Murray ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Biomeasure Inc   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Allo threonine; Biological activity; Hsst receptor; Hydroxyvaline; Octreotide; Sandostatin; Somatostatin; Synthesis

Indexed keywords

CHEMICAL MODIFICATION; CONFORMATIONS; MOLECULAR STRUCTURE; POLYPEPTIDES; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

ALLOTHREONINE; BIOLOGICAL ACTIVITY; HYDROXYVALINE; OCTREOTIDE; SANDOSTATIN; SOMATOSTATIN;

HORMONES;

OCTREOTIDE; OCTREOTIDE AMIDE; OCTREOTIDE[6 ALLOTHREONINE] AMIDE; OCTREOTIDE[6 BETA HYDROXYVALINE] AMIDE; OCTREOTIDE[6 DEXTRO ALLOTHREONINE] AMIDE; OCTREOTIDE[6 DEXTRO BETA HYDROXYVALINE] AMIDE; OCTREOTIDE[6 DEXTRO THREONINE] AMIDE; OCTREOTIDE[8 ALLOTHREONINE] AMIDE; OCTREOTIDE[8 BETA HYDROXYVALINE] AMIDE; OCTREOTIDE[8 DEXTRO ALLOTHREONINE] AMIDE; OCTREOTIDE[8 DEXTRO THREONINE] AMIDE; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; HUMANS; OCTREOTIDE; RADIOLIGAND ASSAY; RECEPTORS, SOMATOSTATIN; STEREOISOMERISM; THREONINE; VALINE;

EID: 0034052525     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(200005)53:6<497::AID-BIP6>3.0.CO;2-Y     Document Type: Article

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