Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit

Journal of Veterinary Pharmacology and Therapeutics

Volumn 31, Issue 1, 2008, Pages 1-8

  Berhane, Y ^a   Bailey, S R ^a   Putignano, C ^b   Elliott, J ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; CARBACHOL; CLOTRIMAZOLE; CYTOCHROME P450 2C9; CYTOCHROME P450 INHIBITOR; ENDOTHELIUM DERIVED RELAXING FACTOR; EPOXYICOSATRIENOIC ACID; IBUPROFEN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM; POTASSIUM; PROSTAGLANDIN SYNTHASE INHIBITOR; SEROTONIN; SUBSTANCE P; SULFAPHENAZOLE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; CORONARY BLOOD VESSEL; DRUG EFFECT; FINGER; HORSE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; REGULATORY MECHANISM; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; ARTERIES; BRADYKININ; CARBACHOL; ENDOTHELIUM, VASCULAR; FEMALE; HINDLIMB; HORSE DISEASES; HORSES; MALE; NG-NITROARGININE METHYL ESTER; NITROPRUSSIDE; SEROTONIN; SUBSTANCE P; VASODILATION; VASODILATOR AGENTS;

EQUIDAE;

EID: 37549015261     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2007.00912.x     Document Type: Article

References (46)

1. Adeagbo, A.S. Triggle, C.R. (1993) Varying extracellular [K+]: a functional approach to separating EDHF- and EDNO-related mechanisms in the perfused rat mesenteric arterial bed. Journal of Cardiovascular Pharmacology, 21, 423 429.
2. Bailey, S.R. Elliott, J. (1999) The role of prostanoids and nitric oxide in endotoxin-induced hyporesponsiveness of equine digital blood vessels. Equine Veterinary Journal, 31, 212 218.
3. Barlow, R.S. White, R.E. (1998) Hydrogen peroxide relaxes porcine coronary arteries by stimulating BKCa channel activity. American Journal of Physiology, 275, H1283 H1289.
4. Beny, J.L. von der Weid, P.Y. (1991) Hydrogen peroxide: an endogenous smooth muscle cell hyperpolarizing factor. Biochemical and Biophysical Research Communications, 176, 378 384.
5. Berhane, Y., Bailey, S.R. Elliott, J. (2003) The properties of endothelial cells derived from the equine digital venous circulation. Journal of Veterinary Pharmacology and Therapeutics, 26 (Suppl. 1 149 150.
6. Berhane, Y., Elliott, J. Bailey, S.R. (2006) Assessment of endothelium-dependent vasodilation in equine digital resistance vessels. Journal of Veterinary Pharmacology and Therapeutics, 29, 387 395.
7. Brandes, R.P., Schmitz-Winnenthal, F.H., Feletou, M., Godecke, A., Huang, P.L., Vanhoutte, P.M., Fleming, I. Busse, R. (2000) An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 97, 9747 9752.
8. Campbell, W.B., Gebremedhin, D., Pratt, P.F. Harder, D.R. (1996) Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circulation Research, 78, 415 423.
9. Chataigneau, T., Feletou, M., Duhault, J. Vanhoutte, P.M. (1998) Epoxyeicosatrienoic acids, potassium channel blockers and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. British Journal of Pharmacology, 123, 574 580.
10. Chauret, N., Gauthier, A., Martin, J. Nicoll-Griffith, D.A. (1997) In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse. Drug Metabolism and Disposition, 25, 1130 1136.
11. Chaytor, A.T., Evans, W.H. Griffith, T.M. (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. Journal of Physiology, 508, 561 573.
12. Chaytor, A.T., Bakker, L.M., Edwards, D.H. Griffith, T.M. (2005) Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery. British Journal of Pharmacology, 144, 108 114.
13. Cogswell, A.M., Johnson, P.J. Adams, H.R. (1995) Evidence for endothelium-derived relaxing factor/nitric oxide in equine digital arteries. American Journal of Veterinary Research, 56, 1637 1641.
14. Cohen, R.A. Vanhoutte, P.M. (1995) Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP. Circulation, 92, 3337 3349.
15. Cohen, R.A., Plane, F., Najibi, S., Huk, I., Malinski, T. Garland, C.J. (1997) Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery. Proceedings of the National Academy of Sciences of the United States of America, 94, 4193 4198.
16. Corriu, C., Feletou, M., Canet, E. Vanhoutte, P.M. (1996) Endothelium-derived factors and hyperpolarization of the carotid artery of the guinea-pig. British Journal of Pharmacology, 119, 959 964.
17. Edwards, G. Weston, A.H. (2001) EDHF - are there gaps in the pathway? Journal of Physiology, 531, 299.
18. Edwards, G., Dora, K.A., Gardener, M.J., Garland, C.J. Weston, A.H. (1998) K+ is an endothelium-derived hyperpolarizing factor in rat arteries. Nature, 396, 269 272.
19. Edwards, G., Thollon, C., Gardener, M.J., Feletou, M., Vilaine, J., Vanhoutte, P.M. Weston, A.H. (2000) Role of gap junctions and EETs in endothelium-dependent hyperpolarization of porcine coronary artery. British Journal of Pharmacology, 129, 1145 1154.
20. Elliott, J., Bryant, C.E. Soydan, J. (1994) The role of nitric oxide in the responses of equine digital veins to vasodilator and vasoconstrictor agents. Equine Veterinary Journal, 26, 378 384.
21. Fichtlscherer, S., Dimmeler, S., Breuer, S., Busse, R., Zeiher, A.M. Fleming, I. (2004) Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease. Circulation, 109, 178 183.
22. Fisslthaler, B., Popp, R., Kiss, L., Potente, M., Harder, D.R., Fleming, I. Busse, R. (1999) Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature, 401, 493 497.
23. Fitzgerald, S.M., Bashari, H., Cox, J.A., Parkington, H.C. Evans, R.G. (2007) Contributions of endothelium-derived relaxing factors to control of hindlimb blood flow in the mouse in vivo. American Journal of Physiology. Heart and Circulatory Physiology, 293, H1072 H1082.
24. Fleming, I., Michaelis, U.R., Bredenkotter, D., Fisslthaler, B., Dehghani, F., Brandes, R.P. Busse, R. (2001) Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circulation Research, 88, 44 51.
25. Griscavage, J.M., Hobbs, A.J. Ignarro, L.J. (1995) Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds. Advances in Pharmacology, 34, 215 234.
26. Halcox, J.P., Narayanan, S., Cramer-Joyce, L., Mincemoyer, R. Quyyumi, A.A. (2001) Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation. American Journal of Physiology. Heart and Circulatory Physiology, 280, H2470 H2477.
27. Harris, D., Martin, P.E., Evans, W.H., Kendall, D.A., Griffith, T.M. Randall, M.D. (2000) Role of gap junctions in endothelium-derived hyperpolarizing factor responses and mechanisms of K(+)-relaxation. European Journal of Pharmacology, 402, 119 128.
28. Hecker, M., Bara, A.T., Bauersachs, J. Busse, R. (1994) Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. Journal of Physiology, 481, 407 414.
29. Hobbs, A.J. Gibson, A. (1990) L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus. British Journal of Pharmacology, 100, 749 752.
30. Hood, D.M., Grosenbaugh, D.A., Mostafa, M.B., Morgan, S.J. Thomas, B.C. (1993) The role of vascular mechanisms in the development of acute equine laminitis. Journal of Veterinary Internal Medicine/American College of Veterinary Internal Medicine, 7, 228 234.
31. Jackson, W.F., Konig, A., Dambacher, T. Busse, R. (1993) Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels. American Journal of Physiology, 264, H238 H243.
32. Katz, L.M., Marr, C.M. Elliott, J. (2003a) Characterization and comparison of the responses of equine digital arteries and veins to endothelin-1. American Journal of Veterinary Research, 64, 1438 1443.
33. Katz, L.M., Marr, C.M. Elliott, J. (2003b) Characterisation of the response of equine digital arteries and veins to substance P. Journal of Veterinary Pharmacology and Therapeutics, 26, 361 368.
34. Kilpatrick, E.V. Cocks, T.M. (1994) Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery. British Journal of Pharmacology, 112, 557 565.
35. Lang, N.N., Luksha, L., Newby, D.E. Kublickiene, K. (2007) Connexin 43 mediates endothelium-derived hyperpolarizing factor-induced vasodilatation in subcutaneous resistance arteries from healthy pregnant women. American Journal of Physiology. Heart and Circulatory Physiology, 292, H1026 H1032.
36. Loyaga-Rendon, R.Y., Sakamoto, S., Aso, T., Iwasaki-Kurashige, K., Takahashi, R. Azuma, H. (2005) Mediators involved in decreasing peripheral vascular resistance with carbachol in the rat hind limb perfusion model. Journal of Pharmacological Sciences, 98, 263 274.
37. Lüscher, T.F. Vanhoutte, P.M. (1990) The Endothelium: Modulator of Cardiovascular Function, pp. 1 228. CRC Press, Boca Raton.
38. Matoba, T., Shimokawa, H., Kubota, H., Morikawa, K., Fujiki, T., Kunihiro, I., Mukai, Y., Hirakawa, Y. Takeshita, A. (2002) Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries. Biochemical and Biophysical Research Communications, 290, 909 913.
39. Parkington, H.C., Chow, J.A.M., Evans, R.G., Coleman, H.A. Tare, M. (2002) Role for endothelium-derived hyperpolarizing factor in vascular tone in rat mesenteric and hindlimb circulations in vivo. Journal of Physiology, 542, 929 937.
40. Parks, W.M., Hoak, J.C. Czervionke, R.L. (1981) Comparative effect of ibuprofen on endothelial and platelet prostaglandin synthesis. Journal of Pharmacology and Experimental Therapeutics, 219, 415 419.
41. Randall, M.D., Alexander, S.P., Bennett, T., Boyd, E.A., Fry, J.R., Gardiner, S.M., Kemp, P.A., McCulloch, A.I. Kendall, D.A. (1996) An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochemical and Biophysical Research Communications, 229, 114 120.
42. Roman, R.J. (2002) P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiological Reviews, 82, 131 185.
43. Shimokawa, H. Matoba, T. (2004) Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. Pharmacological Research, 49, 543 549.
44. Vanheel, B. Van de Voorde, J. (2000) EDHF and residual NO: different factors. Cardiovascular Research, 46, 370 375.
45. Vanheel, B., Van de Voorde, J. Leusen, I. (1994) Contribution of nitric oxide to the endothelium-dependent hyperpolarization in rat aorta. Journal of Physiology, 475, 277 284.
46. Zygmunt, P.M., Edwards, G., Weston, A.H., Davis, S.C. Hogestatt, E.D. (1996) Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. British Journal of Pharmacology, 118, 1147 1152.