Age-related change in the retinoid X receptor beta gene expression in peripheral blood mononuclear cells of healthy volunteers: Effect of 13-cis retinoic acid supplementation

Mechanisms of Ageing and Development

Volumn 128, Issue 11-12, 2007, Pages 594-600

  Brtko, J ^a   Rock, E ^b   Nezbedova, P ^a   Krizanova, O ^c   Dvorcakova, M ^a   Minet Quinard, R ^d   Farges, M C ^d   Ribalta, J ^e   Winklhofer Roob, B M ^f   Vasson, M P ^d   Macejova, D ^a  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b CEMAGREF   (France)

^c INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

^d Pharmacy School   (France)

^e INSTITUT D INVESTIGACIÓ SANITÀRIA PERE VIRGILI IISPV   (Spain)

^f UNIVERSITY OF GRAZ   (Austria)

Author keywords

Ageing; Gene expression; Human; Nuclear receptor; Retinoid

Indexed keywords

ALITRETINOIN; CURACNE; ISOTRETINOIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; RETINOL; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRY SKIN; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; MALE; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNSPECIFIED SIDE EFFECT; VITAMIN SUPPLEMENTATION;

ADULT; AGE FACTORS; AGED; AGING; CELL AGING; DIETARY SUPPLEMENTS; DOWN-REGULATION; HUMANS; ISOTRETINOIN; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; RECEPTORS, RETINOIC ACID; REFERENCE VALUES; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; RNA, MESSENGER; TIME FACTORS; TRANSGLUTAMINASES; TRETINOIN;

EID: 37449010532     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2007.08.005     Document Type: Article

References (32)

1. Andrews N.C., and Faller D.V. A rapid micropreparation technique for extraction of DNA binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19 (1991) 2499
2. Aranda A., and Pascual A. Nuclear hormone receptors and gene expression. Physiol. Rev. 81 (2001) 1269-1304
3. Astrom A., Pettersson U., Chambon P., and Voorhees J.J. Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing. J. Biol. Chem. 269 (1994) 265-273
4. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 10 (1996) 940-945
5. DeLuca L.M. Retinoids and their receptors in differentiation, embryogenesis and neoplasia. FASEB J. 5 (1991) 2924-2933
6. Durand B., Saunders M., Gaudon C., Roy B., Losson R., and Chambon P. Activation function (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutively activating domain and influence of the nature of the response element. EMBO J. 13 (1994) 5370-5382
7. Dvorcakova M., Macejova D., Blazickova S., Pallet V., Higueret P., Vasson M.-P., Walrand S., Rock E., and Brtko J. Transglutaminases: protein cross-linking enzymes. In: Antalik M. (Ed). Structure and Stability of Biomacromolecules (2001), SAS, Kosice, Slovak Republic 33-34
8. Enderlin V., Alfos S., Pallet V., Garcin H., Azais-Braesco V., Jaffard R., and Higueret P. Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: effect of the administration of retinoids. FEBS Lett. 412 (1997) 629-632
9. Feart C., Pallet V., Boucheron C., Higueret D., Alfos S., Letenneur L., Dartigues J.F., and Higueret P. Aging affects the retinoic acid and the triiodothyronine nuclear receptor mRNA expression in human peripheral blood mononuclear cells. Eur. J. Endocrinol. 152 (2005) 449-458
10. Germain P., Staels B., Dacquet C., Spedding M., and Laudet V. Overview of nomenclature of nuclear receptors. Pharmacol. Rev. 58 (2006) 685-704
11. Goodman D.S. Vitamin A and retinoids in health and disease. N. Engl. J. Med. 16 (1984) 1023-1031
12. Gorgun G., and Foss F. Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox. Blood 100 (2002) 1399-1403
13. Kimura Y., Suzuki T., Kaneko C., Darnel A.D., Moriya T., Suzuki S., Handa M., Ebina M., Nukiwa T., and Sasano H. Retinoid receptors in the developing human lung. Clin. Sci. (Lond.) 103 (2002) 613-621
14. Lomo J., Smeland E.B., Ulven S., Natarajan V., Blomhoff R., Gandhi R., Dawson M.I., and Blomhoff H.K. RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes. J. Cell. Physiol. 175 (1998) 68-77
15. Lotan R. Retinoids and apoptosis: implication for cancer chemoprevention and therapy. J. Natl. Cancer Inst. 87 (1995) 1655-1657
16. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-273
17. Mangelsdorf D.J., and Evans R.M. The RXR heterodimers and orphan receptors. Cell 83 (1995) 841-850
18. Mascrez B., Ghyselinck N.B., Watanabe M., Annicotte J.S., Chambon P., Auwerx J., and Mark M. Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep. 5 (2004) 285-290
19. Pallet V., Azais-Braesco V., Enderlin V., Grolier P., Noel-Suberville C., Garcin H., and Higueret P. Aging decreases retinoic acid and triiodothyronine nuclear expression in rat liver: exogenous retinol and retinoic acid differentially modulate this decreased expression. Mech. Ageing Dev. 15 (1997) 123-136
20. Piacentini M., Ceru M.P., Dini L., Di Rao M., Piredda L., Thomazy V., Davies P.J., and Fesus L. In vivo and in vitro induction of "tissue" transglutaminase in rat hepatocytes by retinoic acid. Biochim. Biophys. Acta 113 (1992) 171-179
21. Saurat J.H. Retinoids and ageing. Horm. Res. 43 (1995) 89-92
22. Schmutzler C., Brtko J., Winzer R., Jakobs T.C., Meissner-Weigl J., Simon D., Goretzki P.E., and Köhrle J. Functional retinoid and thyroid hormone receptors in human thyroid-carcinoma cell lines and tissues. Int. J. Cancer 76 (1998) 368-376
23. Stephensen C.B. Vitamin A, infection, and immune function. Annu. Rev. Nutr. 21 (2001) 167-192
24. Stephensen C.B., Rasooly R., Jiang X., Ceddia M.A., Weaver C.T., Chandraratna R.A.S., and Bucy R.P. Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. J. Immunol. 168 (2002) 4495-4503
25. Szabova L., Macejova D., Dvorcakova M., Blazickova S., Zorad S., Walrand S., Cardinault N., Vasson M.-P., Rock E., and Brtko J. Expression of nuclear retinoic acid receptors in peripheral blood mononuclear cells (PBMC) of healthy subjects. Life Sci. 72 (2003) 831-836
26. Szanto A., Narkar V., Shen Q., Uray I.P., Davies P.J.A., and Nagy L. Retinoid X receptors: X-ploring their (patho)physiological functions. Cell Death Differ. 11 (2004) S126-S143
27. Szondy Z., Lecoeur H., Fesus L., and Gougeon M.L. All-trans retinoic acid inhibition of anti-CD3-induced T cell apoptosis in human immunodeficiency virus infection mostly concerns CD4 T lymphocytes and is mediated via regulation of CD95 ligand expression. J. Infect. Dis. 178 (1998) 1288-1298
28. Walrand S., Moreau K., Caldefie F., Tridon A., Chassagne J., Portefaix G., Cynober L., Beaufrère B., Vasson M.-P., and Boirie Y. Specific and nonspecific immune response to fasting and refeeding is differentially affected in healthy young and elderly humans. Am. J. Clin. Nutr. 74 (2001) 670-678
29. Willy P.J., and Mangelsdorf D.J. Nuclear orphan receptors: the search for novel ligands and signaling pathways. Horm. Signal. 1 (1998) 307-358
30. Wyss R., and Bucheli F. Determination of endogenous levels of 13-cis-retinoic acid (isotretinoin), all-trans-retinoic acid (tretinoin) and their 4-oxo metabolites in human and animal plasma by high-performance liquid chromatography with automated column switching and ultraviolet detection. J. Chromatogr. 24 (1997) 31-47
31. Yang Y., Vacchio M.S., and Ashwell J.D. 9-Cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 6170-6174
32. Yang Y., Minucci S., Ozato K., Heyman R.A., and Ashwell J.D. Efficient inhibition of activation-induced Fas ligand up-regulation and T cell apoptosis by retinoids requires occupancy of both retinoid X receptors and retinoic acid receptors. J. Biol. Chem. 270 (1995) 18672-18677