The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of Type 2 Diabetes patients

BMC Genetics

Volumn 8, Issue , 2007, Pages

  López Orduña, Eduardo ^a,b   Cruz, Miguel ^b   García Mena, Jaime ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE MGAT4A; MESSENGER RNA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ALPHA 1,3 MANNOSYLGLYCOPROTEIN BETA 1,4 N ACETYLGLUCOSAMINYLTRANSFERASE; ALPHA-1,3-MANNOSYLGLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLGLUCOSAMINYLTRANSFERASE;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENETIC MARKER; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; HALF LIFE TIME; HUMAN; LEUKEMIA CELL LINE; LEUKOCYTE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; ENZYMOLOGY; GENETICS; POLYMERASE CHAIN REACTION;

MUS;

CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; HALF-LIFE; HUMANS; JURKAT CELLS; LEUKOCYTES; N-ACETYLGLUCOSAMINYLTRANSFERASES; POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 37449007461     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-8-73     Document Type: Article

References (21)

1. Yoshida A Minowa MT Takamatsu S Hara T Oguri S Ikenaga H Takeuchi M: Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: Alpha 1,3-d-mannoside beta1, 4-N-acetyl glucosaminyl transferase. Glycobiology 1999, 9:303-310. 10.1093/glycob/ 9.3.303 10024668
2. Parry S Hadaschik D Blancher C Kumaran MK Bochkina N Morris HR Richardson S Aitman TJ Gauguier D Siddle K Scott J Dell A: Glycomics investigation into insulin action. Biochim Biophys Acta 2006, 4:652-668.
3. Ide Y Miyoshi E Nakagawa T Gu J Tanemura M Nishida T Ito T Yamamoto H Kozutsumi Y Taniguchi N: Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. Biochem Biophys Res Commun 2006, 34:1478-1482.
4. Takamatsu S Oguri S Minowa MT Yoshida A Nakamura K Takeuchi M Kobata A: Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: A possible enzymatic basis of the formation of abnormal biantennary sugar chain. Cancer Res 1999, 59:3949-3953. 10463590
5. Vozarova B Weyer C Lindsay RS Pratley RE Bogardus C Tataranni PA: High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 2002, 51:455-461. 10.2337/diabetes.51.2.455 11812755
6. Ford ES: Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults. Am J Epidemiol 2002, 155:57-64. 10.1093/aje/155.1.57 11772785
7. Ohshita K Yamane K Hanafusa M Mori H Mito K Okubo M Hara H Kohno N; Elevated white blood cell count in subjects with impaired glucose tolerance. Diabetes Care 2004, 27:491-496. 10.2337/diacare.27.2.491 14747234
8. Pertynska-Marczewska M Kiriakidis S Wait R Beech J Feldmann M Paleolog EM; Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages. Cytokine 2004, 28:35-47. 10.1016/j.cyto.2004.06.006 15341924
9. Shurtz-Swirski R Sela S Herskovits AT Shasha SM Shapiro G Nasser L Kristal B; Involvement of peripheral polymorphonuclear leukocytes in oxidative stress and inflammation in type 2 diabetic patients. Diabetes Care 2001, 24:104-110. 10.2337/diacare.24.1.104 11194213
10. Hofmann MA Schiekofer S Isermann B Kanitz M Henkels M Joswig M Treusch A Morcos M Weiss T Borcea V Abdel Khalek AK Amiral J Tritschler H Ritz E Wahl P Ziegler R Bierhaus A Nawroth PP; Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-κB. Diabetologia 1999, 42:222-232. 10.1007/s001250051142 10064103
11. Lee FT Cao Z Long DM Panagiotopoulos S Jerums G Cooper ME Forbes JM: Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. J Am Soc Nephrol 2004, 15:2139-2151. 10.1097/01.ASN.0000135055.61833.A8 15284299
12. Sato Y Kuwajima M Kamiya H Harashima H: Calpain-10 is a predictive gene for type 2 diabetes: Evidence from a novel screening system using white blood cells of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biol Pharm Bull 2003, 26:1765-1768. 10.1248/bpb.26.1765 14646187
13. López-Orduña E García-Mena J García-Macedo R Stumvoll M Cruz M: CAPN10 mRNA splicing and decay is not affected by a SNP associated with susceptibility to type 2 diabetes. Biochem Biophys Res Commun 2007, 358:831-836. 10.1016/j.bbrc.2007.05.001 17511963
14. Ohtsubo K Takamatsu S Minowa MT Yoshida A Takeuchi M Marth JD: Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 2005, 123:1307-1321. 10.1016/j.cell.2005.09.041 16377570
15. Thorens B: A toggle for type 2 diabetes? N Engl J Med 2006, 15:1636-1638. 10.1056/NEJMcibr060422
16. Schulze MB Rimm EB Shai I Rifai N Hu FB: Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes. Diabetes Care 2004, 27:1680-1687. 10.2337/ diacare.27.7.1680 15220246
17. Ziegler D: Type 2 Diabetes as an Inflammatory Cardiovascular Disorder. Current Molecular Medicine 2005, 5:309-322. 10.2174/1566524053766095 15892650
18. Murdolo G Smith U: The dysrAgulated adipose tissue: a connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis. Nutr Metab Cardiovasc Dis 2006, 16(Suppl 1):35-38. 10.1016/j.numecd.2005.10.016
19. Yang E van Nimwegen E Zavolan M Rajewsky N Schroeder M Magnasco M Darnell JE: Decay rateC of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res 2003, 13:1863-1872. 403777 12902380 10.1101/gr.997703
20. van Oostrom AJ van Wijk JP Sijmonsma TP Rabelink TJ Castro Cabezas M: Increased expression of activation markers on monocytes and neutrophils in type 2 diabetes. Neth J Med 2004, 9:320-325.
21. Friedewald WT Levy RI Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502. 4337382