A toggle for type 2 diabetes?

New England Journal of Medicine

Volumn 354, Issue 15, 2006, Pages 1636-1638

  Thorens, Bernard ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; ALPHA 1,3 MANNOSYLGLYCOPROTEIN BETA 1,4 N ACETYLGLUCOSAMINYLTRANSFERASE; ALPHA-1,3-MANNOSYLGLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE; MGAT14 PROTEIN, MOUSE; N ACETYLGLUCOSAMINYLTRANSFERASE;

ARTICLE; ENZYME ACTIVITY; GENETIC ASSOCIATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN RELEASE; MUTAGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ACTIVE TRANSPORT; ANIMAL; CHEMISTRY; DIET; FAT INTAKE; GENETICS; HUMAN; METABOLISM; MOUSE; SECRETION; TRANSGENIC MOUSE;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; DIABETES MELLITUS, TYPE 2; DIET; DIETARY FATS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; N-ACETYLGLUCOSAMINYLTRANSFERASES;

EID: 33645757801     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr060422     Document Type: Article

References (3)

1. Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 2005;123:1307-21.
2. Guillam M-T, Hümmler E, Schaerer E, et al. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking GLUT2. Nat Genet 1997;17:327-30. [Erratum, Nat Genet 1997;17:503.]
3. Thorens B, Guillam M-T, Beermann F, Burcelin R, Jaquet M. Transgenic reexpression of Glut1 or Glut2 in pancreatic β cells rescues Glut2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 2000;275:23751-8.