Dietary quercetin does not affect pituitary lutenizing hormone (LH) expression and has no uterotropic effects in ovariectomized Sprague-Dawley rats

Food and Chemical Toxicology

Volumn 46, Issue 2, 2008, Pages 513-518

  Rachoń, Dominik ^a,b   Vortherms, Tina ^b   Seidlová Wuttke, Dana ^b   Jarry, Hubertus ^b   Wuttke, Wolfgang ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Estrogenic effects; Flavonoids; LH; Pituitary; Quercetin; Uterus

Indexed keywords

COMPLEMENT COMPONENT C3; ESTRADIOL BENZOATE; LUTEINIZING HORMONE; LUTEINIZING HORMONE BETA SUBUNIT; MESSENGER RNA; PROGESTERONE RECEPTOR; QUERCETIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; ESTROGEN ACTIVITY; FEMALE; FOOD; HORMONAL REGULATION; IN VITRO STUDY; NONHUMAN; OVARIECTOMY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SPRAGUE DAWLEY RAT; TREATMENT DURATION;

ANIMALS; ANTIOXIDANTS; CONTRACEPTIVE AGENTS; DIET; ESTRADIOL; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR I; LUTEINIZING HORMONE; OVARIECTOMY; PITUITARY GLAND; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RNA, MESSENGER; UTERUS;

ANIMALIA; RATTUS; RODENTIA; SUS;

EID: 37349086785     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.08.031     Document Type: Article

References (28)

1. Adesanya O.O., Zhou J., Samathanam C., Powell-Braxton L., and Bondy C.A. Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle. Proc. Natl. Acad. Sci. USA 96 (1999) 3287-3291
2. Agullo G., Gamet-Payrastre L., Fernandez Y., Anciaux N., Demigne C., and Remesy C. Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells). Cancer Lett. 105 (1996) 61-70
3. Christoffel J., Rimoldi G., and Wuttke W. Effects of 8-prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3-month treatment. J. Endocrinol. 188 (2006) 397-405
4. Couse J.F., and Korach K.S. Estrogen receptor null mice: what have we learned and where will they lead us. Endocr. Rev. 20 (1999) 358-417
5. Diel P., Schulz T., Smolnikar K., Strunck E., Vollmer G., and Michna H. Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity. J. Steroid. Biochem. Mol. Biol. 73 (2000) 1-10
6. Geleijnse J.M., Launer L.J., Van der Kuip D.A., Hofman A., and Witteman J.C. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am. J. Clin. Nutr. 75 (2002) 880-886
7. Heid C.A., Stevens J., Livak K.J., and Williams P.M. Real time quantitative PCR. Genome Res. 6 (1996) 986-994
8. Heikaus S., Winterhager E., Traub O., and Grummer R. Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens. J. Mol. Endocrinol. 29 (2002) 239-249
9. Hertog M.G., Hollman P.C., and Katan M.B. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem. 40 (1992) 2379-2383
10. Hopert A.C., Beyer A., Frank K., Strunck E., Wunsche W., and Vollmer G. Characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model. Environ. Health. Perspect. 106 (1998) 581-586
11. Jarry H., Metten M., Spengler B., Christoffel V., and Wuttke W. In vitro effects of the Cimicifuga racemosa extract BNO 1055. Maturitas 44 Suppl. 1 (2003) S31-S38
12. Klotz D.M., Hewitt S.C., Ciana P., Raviscioni M., Lindzey J.K., Foley J., Maggi A., DiAugustine R.P., and Korach K.S. Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J. Biol. Chem. 277 (2002) 8531-8537
13. Knekt P., Jarvinen R., Seppanen R., Hellovaara M., Teppo L., Pukkala E., and Aromaa A. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am. J. Epidemiol. 146 (1997) 223-230
14. Kuiper G.G., Lemmen J.G., Carlsson B., Corton J.C., Safe S.H., van der Saag P.T., van der Burg B., and Gustafsson J.A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139 (1998) 4252-4263
15. Kuo S.M. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett. 110 (1996) 41-48
16. Maggiolini M., Bonofiglio D., Marsico S., Panno M.L., Cenni B., Picard D., and Ando S. Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol. Pharmacol. 60 (2001) 595-602
17. Miodini P., Fioravanti L., Di Fronzo G., and Cappelletti V. The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br. J. Cancer 80 (1999) 1150-1155
18. Odum J., Lefevre P.A., Tittensor S., Paton D., Routledge E.J., Beresford N.A., Sumpter J.P., and Ashby J. The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Regul. Toxicol. Pharmacol. 25 (1997) 176-188
19. Rachon D., Vortherms T., Seidlova-Wuttke D., and Wuttke W. Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. Maturitas 57 (2007) 161-170
20. Rice-Evans C.A., Miller N.J., and Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20 (1996) 933-956
21. Roth C., Schricker M., Lakomek M., Strege A., Heiden I., Luft H., Munzel U., Wuttke W., and Jarry H. Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model. J. Endocrinol. 169 (2001) 361-371
22. Spanos G.A., and Wrolstad R.E. Phenolics of apple, pear, and white grape juices and their changes with processing and storage. A review. J. Agric. Food Chem. 40 (1992) 1478-1487
23. Strunck E., Stemmann N., Hopert A., Wunsche W., Frank K., and Vollmer G. Relative binding affinity does not predict biological response to xenoestrogens in rat endometrial adenocarcinoma cells. J. Steroid. Biochem. Mol. Biol. 74 (2000) 73-81
24. Sundstrom S.A., Komm B.S., Ponce-de-Leon H., Yi Z., Teuscher C., and Lyttle C.R. Estrogen regulation of tissue-specific expression of complement C3. J. Biol. Chem. 264 (1989) 16941-16947
25. van der Woude H., Gliszczynska-Swiglo A., Struijs K., Smeets A., Alink G.M., and Rietjens I.M. Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett. 200 (2003) 41-47
26. van der Woude H., Ter Veld M.G., Jacobs N., van der Saag P.T., Murk A.J., and Rietjens I.M. The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Mol. Nutr. Food Res. 49 (2005) 763-771
27. Virgili F., Acconcia F., Ambra R., Rinna A., Totta P., and Marino M. Nutritional flavonoids modulate estrogen receptor alpha signaling. IUBMB Life 56 (2004) 145-151
28. Zava D.T., and Duwe G. Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr. Cancer 27 (1997) 31-40