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Volumn 18, Issue 1, 2008, Pages 15-22

A study on the action of vitamin E supplementation on plasminogen activator inhibitor type 1 and platelet nitric oxide production in type 2 diabetic patients

Author keywords

Na+ K+ ATPase; Nitric oxide; Plasminogen activator inhibitor type 1; Type 2 diabetes mellitus; Vitamin E

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA TOCOPHEROL; ANTIOXIDANT; INTERCELLULAR ADHESION MOLECULE 1; NITRIC OXIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERPINE1 PROTEIN, HUMAN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

EID: 37349083093     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2007.01.002     Document Type: Article
Times cited : (11)

References (44)
  • 1
    • 0025824726 scopus 로고
    • The fibrinolytic system in diabetes mellitus
    • Gough S.C., and Grant P.J. The fibrinolytic system in diabetes mellitus. Diabet Med 8 10 (1991) 898-905
    • (1991) Diabet Med , vol.8 , Issue.10 , pp. 898-905
    • Gough, S.C.1    Grant, P.J.2
  • 2
    • 0029822786 scopus 로고    scopus 로고
    • Thrombogenic and fibrinolytic factors and cardiovascular risk in non-insulin-dependent diabetes mellitus
    • Juhan-Vague I., Alessi M.C., and Vague P. Thrombogenic and fibrinolytic factors and cardiovascular risk in non-insulin-dependent diabetes mellitus. Ann Med 28 4 (1996) 371-380
    • (1996) Ann Med , vol.28 , Issue.4 , pp. 371-380
    • Juhan-Vague, I.1    Alessi, M.C.2    Vague, P.3
  • 3
    • 0025211861 scopus 로고
    • Characterization and fibrinolytic properties of human omental tissue mesothelial cells. Comparison with endothelial cells
    • van Hinsbergh V.W., Kooistra T., Scheffer M.A., Hajo van Bockel J., and van Muijen G.N. Characterization and fibrinolytic properties of human omental tissue mesothelial cells. Comparison with endothelial cells. Blood 75 7 (1990) 1490-1497
    • (1990) Blood , vol.75 , Issue.7 , pp. 1490-1497
    • van Hinsbergh, V.W.1    Kooistra, T.2    Scheffer, M.A.3    Hajo van Bockel, J.4    van Muijen, G.N.5
  • 4
    • 0027454614 scopus 로고
    • Attenuated fibrinolysis and accelerated atherogenesis in type II diabetic patients
    • Schneider D.J., Nordt T.K., and Sobel B.E. Attenuated fibrinolysis and accelerated atherogenesis in type II diabetic patients. Diabetes 42 1 (1993) 1-7
    • (1993) Diabetes , vol.42 , Issue.1 , pp. 1-7
    • Schneider, D.J.1    Nordt, T.K.2    Sobel, B.E.3
  • 5
    • 0024996265 scopus 로고
    • Diabetes, fibrinogen, and risk of cardiovascular disease: the Framingham experience
    • Kannel W.B., D'Agostino R.B., Wilson P.W., Belanger A.J., and Gagnon D.R. Diabetes, fibrinogen, and risk of cardiovascular disease: the Framingham experience. Am Heart J 120 3 (1990) 672-676
    • (1990) Am Heart J , vol.120 , Issue.3 , pp. 672-676
    • Kannel, W.B.1    D'Agostino, R.B.2    Wilson, P.W.3    Belanger, A.J.4    Gagnon, D.R.5
  • 6
    • 0028008336 scopus 로고
    • Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients
    • McGill J.B., Schneider D.J., Arfken C.L., Lucore C.L., and Sobel B.E. Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients. Diabetes 43 1 (1994) 104-109
    • (1994) Diabetes , vol.43 , Issue.1 , pp. 104-109
    • McGill, J.B.1    Schneider, D.J.2    Arfken, C.L.3    Lucore, C.L.4    Sobel, B.E.5
  • 7
    • 0025918063 scopus 로고
    • Contrasting fibrinolytic responses in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes
    • Walmsley D., Hampton K.K., and Grant P.J. Contrasting fibrinolytic responses in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes. Diabet Med 8 10 (1991) 954-959
    • (1991) Diabet Med , vol.8 , Issue.10 , pp. 954-959
    • Walmsley, D.1    Hampton, K.K.2    Grant, P.J.3
  • 8
    • 0031837903 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men
    • Byberg L., Siegbahn A., Berglund L., McKeigue P., Reneland R., and Lithell H. Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men. Arterioscler Thromb Vasc Biol 18 2 (1998) 258-264
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , Issue.2 , pp. 258-264
    • Byberg, L.1    Siegbahn, A.2    Berglund, L.3    McKeigue, P.4    Reneland, R.5    Lithell, H.6
  • 9
    • 0025251843 scopus 로고
    • Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low density lipoprotein
    • Stiko-Rahm A., Wiman B., Hamsten A., and Nilsson J. Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low density lipoprotein. Arteriosclerosis 10 6 (1990) 1067-1073
    • (1990) Arteriosclerosis , vol.10 , Issue.6 , pp. 1067-1073
    • Stiko-Rahm, A.1    Wiman, B.2    Hamsten, A.3    Nilsson, J.4
  • 10
    • 0026780403 scopus 로고
    • Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose
    • Maiello M., Boeri D., Podesta F., Cagliero E., Vichi M., Odetti P., et al. Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose. Diabetes 41 8 (1992) 1009-1015
    • (1992) Diabetes , vol.41 , Issue.8 , pp. 1009-1015
    • Maiello, M.1    Boeri, D.2    Podesta, F.3    Cagliero, E.4    Vichi, M.5    Odetti, P.6
  • 11
    • 0028916348 scopus 로고
    • The defence against free radicals protects endothelial cells from hyperglycaemia-induced plasminogen activator inhibitor 1 over-production
    • Ceriello A., Curcio F., dello Russo P., Pegoraro I., Stel G., Amstad P., et al. The defence against free radicals protects endothelial cells from hyperglycaemia-induced plasminogen activator inhibitor 1 over-production. Blood Coagul Fibrinolysis 6 2 (1995) 133-137
    • (1995) Blood Coagul Fibrinolysis , vol.6 , Issue.2 , pp. 133-137
    • Ceriello, A.1    Curcio, F.2    dello Russo, P.3    Pegoraro, I.4    Stel, G.5    Amstad, P.6
  • 12
    • 0344393594 scopus 로고    scopus 로고
    • Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-l-arginine methyl ester-induced myocardial injury
    • Oestreicher E.M., Martinez-Vasquez D., Stone J.R., Jonasson L., Roubsanthisuk W., Mukasa K., et al. Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-l-arginine methyl ester-induced myocardial injury. Circulation 108 20 (2003) 2517-2523
    • (2003) Circulation , vol.108 , Issue.20 , pp. 2517-2523
    • Oestreicher, E.M.1    Martinez-Vasquez, D.2    Stone, J.R.3    Jonasson, L.4    Roubsanthisuk, W.5    Mukasa, K.6
  • 13
    • 0000463921 scopus 로고    scopus 로고
    • Nitric oxide: Biosynthesis and biological significance
    • Marletta M.A. Nitric oxide: Biosynthesis and biological significance. Trends Pharmacol Sci 158 (1998) 348-352
    • (1998) Trends Pharmacol Sci , vol.158 , pp. 348-352
    • Marletta, M.A.1
  • 14
    • 0030711558 scopus 로고    scopus 로고
    • Nitric oxide synthases: which, where, how, and why?
    • Michel T., and Feron O. Nitric oxide synthases: which, where, how, and why?. J Clin Invest 100 9 (1997) 2146-2152
    • (1997) J Clin Invest , vol.100 , Issue.9 , pp. 2146-2152
    • Michel, T.1    Feron, O.2
  • 15
    • 0344823963 scopus 로고    scopus 로고
    • A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells
    • Wolfsgruber W., Feil S., Brummer S., Kuppinger O., Hofmann F., and Feil R. A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells. Proc Natl Acad Sci USA 100 23 (2003) 13519-13524
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.23 , pp. 13519-13524
    • Wolfsgruber, W.1    Feil, S.2    Brummer, S.3    Kuppinger, O.4    Hofmann, F.5    Feil, R.6
  • 17
    • 0033955385 scopus 로고    scopus 로고
    • Dual regulatory effects of nitric oxide on plasminogen activator inhibitor type 1 expression in endothelial cells
    • Swiatkowska M., Cierniewska-Cieslak A., Pawlowska Z., and Cierniewski C.S. Dual regulatory effects of nitric oxide on plasminogen activator inhibitor type 1 expression in endothelial cells. Eur J Biochem 267 4 (2000) 1001-1007
    • (2000) Eur J Biochem , vol.267 , Issue.4 , pp. 1001-1007
    • Swiatkowska, M.1    Cierniewska-Cieslak, A.2    Pawlowska, Z.3    Cierniewski, C.S.4
  • 18
    • 0031882609 scopus 로고    scopus 로고
    • Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients
    • Rabini R.A., Staffolani R., Fumelli P., Mutus B., Curatola G., and Mazzanti L. Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients. Diabetologia 41 1 (1998) 101-104
    • (1998) Diabetologia , vol.41 , Issue.1 , pp. 101-104
    • Rabini, R.A.1    Staffolani, R.2    Fumelli, P.3    Mutus, B.4    Curatola, G.5    Mazzanti, L.6
  • 19
    • 0141429031 scopus 로고    scopus 로고
    • Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man
    • Krebs M., Geiger M., Polak K., Vales A., Schmetterer L., Wagner O.F., et al. Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man. Thromb Haemost 90 3 (2003) 422-428
    • (2003) Thromb Haemost , vol.90 , Issue.3 , pp. 422-428
    • Krebs, M.1    Geiger, M.2    Polak, K.3    Vales, A.4    Schmetterer, L.5    Wagner, O.F.6
  • 21
    • 0026657363 scopus 로고
    • The role of lipid peroxidation and antioxidants in oxidative modification of LDL
    • Esterbauer H., Gebicki J., Puhl H., and Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med 13 (1992) 341-390
    • (1992) Free Radic Biol Med , vol.13 , pp. 341-390
    • Esterbauer, H.1    Gebicki, J.2    Puhl, H.3    Jurgens, G.4
  • 23
    • 8644277343 scopus 로고    scopus 로고
    • Effect of 4G/5G PAI-1 polymorphism on the response of PAI-1 activity to vitamin E supplementation in Type 2 diabetic patients
    • Testa R., Bonfigli A.R., Sirolla C., Boemi M., Manfrini S., Mari D., et al. Effect of 4G/5G PAI-1 polymorphism on the response of PAI-1 activity to vitamin E supplementation in Type 2 diabetic patients. Diabetes Nutr Metab 17 4 (2004) 217-221
    • (2004) Diabetes Nutr Metab , vol.17 , Issue.4 , pp. 217-221
    • Testa, R.1    Bonfigli, A.R.2    Sirolla, C.3    Boemi, M.4    Manfrini, S.5    Mari, D.6
  • 24
    • 0034457140 scopus 로고    scopus 로고
    • Chronic vitamin E administration improves brachial reactivity and increases intracellular magnesium concentration in type II diabetic patients
    • Paolisso G., Tagliamonte M.R., Barbieri M., Zito G.A., Gambardella A., Varricchio G., et al. Chronic vitamin E administration improves brachial reactivity and increases intracellular magnesium concentration in type II diabetic patients. J Clin Endocrinol Metab 85 1 (2000) 109-115
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.1 , pp. 109-115
    • Paolisso, G.1    Tagliamonte, M.R.2    Barbieri, M.3    Zito, G.A.4    Gambardella, A.5    Varricchio, G.6
  • 25
    • 0036072428 scopus 로고    scopus 로고
    • Vitamin E supplementation reduces plasma vascular cell adhesion molecule-1 and von Willebrand factor levels and increases nitric oxide concentrations in hypercholesterolemic patients
    • Desideri G., Marinucci M.C., Tomassoni G., Masci P.G., Santucci A., and Ferri C. Vitamin E supplementation reduces plasma vascular cell adhesion molecule-1 and von Willebrand factor levels and increases nitric oxide concentrations in hypercholesterolemic patients. J Clin Endocrinol Metab 87 6 (2002) 2940-2945
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.6 , pp. 2940-2945
    • Desideri, G.1    Marinucci, M.C.2    Tomassoni, G.3    Masci, P.G.4    Santucci, A.5    Ferri, C.6
  • 26
    • 0029798873 scopus 로고    scopus 로고
    • Vitamin E in humans: demand and delivery
    • Traber M.G., and Sies H. Vitamin E in humans: demand and delivery. Annu Rev Nutr 16 (1996) 321-347
    • (1996) Annu Rev Nutr , vol.16 , pp. 321-347
    • Traber, M.G.1    Sies, H.2
  • 27
    • 0027447237 scopus 로고
    • Measurement of nitric oxide in biological models
    • Archer S. Measurement of nitric oxide in biological models. FASEB J 7 (1993) 349-360
    • (1993) FASEB J , vol.7 , pp. 349-360
    • Archer, S.1
  • 28
    • 0017184389 scopus 로고
    • A rapid and sensitive Method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. A rapid and sensitive Method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 30
    • 0000154206 scopus 로고
    • The colorimetric determination of phosphorus
    • Fiske C.H., and Subbarow Y. The colorimetric determination of phosphorus. J Biol Chem 66 (1925) 375-400
    • (1925) J Biol Chem , vol.66 , pp. 375-400
    • Fiske, C.H.1    Subbarow, Y.2
  • 31
    • 0036240397 scopus 로고    scopus 로고
    • Nitric oxide therapies in vascular diseases
    • Kurowska E.M. Nitric oxide therapies in vascular diseases. Curr Pharm Des 8 3 (2002) 155-166
    • (2002) Curr Pharm Des , vol.8 , Issue.3 , pp. 155-166
    • Kurowska, E.M.1
  • 32
    • 23944493587 scopus 로고    scopus 로고
    • Vitamin E, oxidative stress, and inflammation
    • Singh U., Devaraj S., and Jialal I. Vitamin E, oxidative stress, and inflammation. Annu Rev Nutr 25 (2005) 151-174
    • (2005) Annu Rev Nutr , vol.25 , pp. 151-174
    • Singh, U.1    Devaraj, S.2    Jialal, I.3
  • 33
    • 4944257390 scopus 로고    scopus 로고
    • Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization
    • Norata G.D., Banfi C., Pirillo A., Tremoli E., Hamsten A., Catapano A.L., et al. Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization. Br J Haematol 127 1 (2004) 97-104
    • (2004) Br J Haematol , vol.127 , Issue.1 , pp. 97-104
    • Norata, G.D.1    Banfi, C.2    Pirillo, A.3    Tremoli, E.4    Hamsten, A.5    Catapano, A.L.6
  • 34
    • 2442429603 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site
    • Hou B., Eren M., Painter C.A., Covington J.W., Dixon J.D., Schoenhard J.A., et al. Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site. J Biol Chem 279 18 (2004) 18127-18136
    • (2004) J Biol Chem , vol.279 , Issue.18 , pp. 18127-18136
    • Hou, B.1    Eren, M.2    Painter, C.A.3    Covington, J.W.4    Dixon, J.D.5    Schoenhard, J.A.6
  • 35
    • 33750842744 scopus 로고    scopus 로고
    • Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity
    • Murakami T., Horigome H., Tanaka K., Nakata Y., Ohkawara K., Katayama Y., et al. Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity. Thromb Res 119 1 (2007) 45-53
    • (2007) Thromb Res , vol.119 , Issue.1 , pp. 45-53
    • Murakami, T.1    Horigome, H.2    Tanaka, K.3    Nakata, Y.4    Ohkawara, K.5    Katayama, Y.6
  • 36
    • 33645636936 scopus 로고    scopus 로고
    • Mediterranean-inspired diet lowers the ratio of serum phospholipid n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects
    • Ambring A., Johansson M., Axelsen M., Gan L., Strandvik B., and Friberg P. Mediterranean-inspired diet lowers the ratio of serum phospholipid n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects. Am J Clin Nutr 83 3 (2006) 575-581
    • (2006) Am J Clin Nutr , vol.83 , Issue.3 , pp. 575-581
    • Ambring, A.1    Johansson, M.2    Axelsen, M.3    Gan, L.4    Strandvik, B.5    Friberg, P.6
  • 37
    • 33744473839 scopus 로고    scopus 로고
    • Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation
    • Dell'Agli M., Fagnani R., Mitro N., Scurati S., Masciadri M., Mussoni L., et al. Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation. J Agric Food Chem 54 9 (2006) 3259-3264
    • (2006) J Agric Food Chem , vol.54 , Issue.9 , pp. 3259-3264
    • Dell'Agli, M.1    Fagnani, R.2    Mitro, N.3    Scurati, S.4    Masciadri, M.5    Mussoni, L.6
  • 38
    • 33746834076 scopus 로고    scopus 로고
    • The effects of diet on inflammation: emphasis on the metabolic syndrome
    • Giugliano D., Ceriello A., and Esposito K. The effects of diet on inflammation: emphasis on the metabolic syndrome. J Am Coll Cardiol 48 4 (2006) 677-685
    • (2006) J Am Coll Cardiol , vol.48 , Issue.4 , pp. 677-685
    • Giugliano, D.1    Ceriello, A.2    Esposito, K.3
  • 39
    • 0035117433 scopus 로고    scopus 로고
    • Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1
    • Martina V., Bruno G.A., Zumpano E., Origlia C., Quaranta L., and Pescarmona G.P. Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1. J Endocrinol Invest 24 1 (2001) 37-41
    • (2001) J Endocrinol Invest , vol.24 , Issue.1 , pp. 37-41
    • Martina, V.1    Bruno, G.A.2    Zumpano, E.3    Origlia, C.4    Quaranta, L.5    Pescarmona, G.P.6
  • 40
    • 0031797874 scopus 로고    scopus 로고
    • Natriuretic factors and nitric oxide suppress plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Role of cGMP in the regulation of the plasminogen system
    • Bouchie J.L., Hansen H., and Feener E.P. Natriuretic factors and nitric oxide suppress plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Role of cGMP in the regulation of the plasminogen system. Arterioscler Thromb Vasc Biol 18 11 (1998) 1771-1779
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , Issue.11 , pp. 1771-1779
    • Bouchie, J.L.1    Hansen, H.2    Feener, E.P.3
  • 41
    • 8444242514 scopus 로고    scopus 로고
    • Adnosine triphosphatase activity of streptozotocin-induced diabetic rat brain microsomes. Effect of vitamin E
    • Das Evcimen N., Ulusu N.N., Karasu C., and Dogru B. Adnosine triphosphatase activity of streptozotocin-induced diabetic rat brain microsomes. Effect of vitamin E. Gen Physiol Biophys 23 3 (2004) 347-355
    • (2004) Gen Physiol Biophys , vol.23 , Issue.3 , pp. 347-355
    • Das Evcimen, N.1    Ulusu, N.N.2    Karasu, C.3    Dogru, B.4
  • 42
    • 0029909002 scopus 로고    scopus 로고
    • Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells
    • Cominacini L., Garbin U., Pasini A.F., Davoli A., Campagnola M., Contessi G.B., et al. Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells. Free Radic Biol Med 22 1-2 (1997) 117-127
    • (1997) Free Radic Biol Med , vol.22 , Issue.1-2 , pp. 117-127
    • Cominacini, L.1    Garbin, U.2    Pasini, A.F.3    Davoli, A.4    Campagnola, M.5    Contessi, G.B.6
  • 43
    • 3042554274 scopus 로고    scopus 로고
    • Effects of antioxidants and nitric oxide on TNF-alpha-induced adhesion molecule expression and NF-kappaB activation in human dermal microvascular endothelial cells
    • Jiang M.Z., Tsukahara H., Ohshima Y., Todoroki Y., Hiraoka M., Maeda M., et al. Effects of antioxidants and nitric oxide on TNF-alpha-induced adhesion molecule expression and NF-kappaB activation in human dermal microvascular endothelial cells. Life Sci 75 10 (2004) 1159-1170
    • (2004) Life Sci , vol.75 , Issue.10 , pp. 1159-1170
    • Jiang, M.Z.1    Tsukahara, H.2    Ohshima, Y.3    Todoroki, Y.4    Hiraoka, M.5    Maeda, M.6


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