Daily variation in endotoxin levels is associated with increased organ failure in critically ill patients

Shock

Volumn 28, Issue 5, 2007, Pages 524-529

  Klein, David J ^a   Derzko, Anastasia ^b   Foster, Debra ^b   Seely, Andrew J E ^c   Brunet, Fabrice ^a   Romaschin, Alexander D ^a   Marshall, John C ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b Spectral Diagnostics Inc   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Critical care; Endotoxin; Organ dysfunction; Sepsis; Variability

Indexed keywords

ENDOTOXIN;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MULTIPLE ORGAN FAILURE; PATHOGENESIS;

ADULT; AGED; COHORT STUDIES; CRITICAL ILLNESS; ENDOTOXINS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PERIODICITY; RETROSPECTIVE STUDIES;

EID: 37349082257     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/shk.0b013e31805363c6     Document Type: Article

References (32)

1. Alexander C, Rietschel ET: Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 7(3):1571-1574, 2001.
2. Westphal O, Westphal U, Sommer T: The history of pyrogen research. In Schlessingers D (ed.): Microbiol 1977. Washington, DC: American Society of Microbiology, pp 221-238, 1997.
3. Klein DJ, Derzko A, Seely A, Foster D, Marshall J: Marker or mediator? Changes in endotoxin activity as a predictor of adverse outcomes in critical illness. Crit Care 9(suppl 1):161, 2005.
4. Opal SM, Scannon PJ, Vincent JL, White M, Carroll SF, Palardy JE, Parejo A, Pribble JP, Lemke JH: Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. J Infect Dis 180(5):1584-1589, 1999.
5. Marshall JC, Foster D, Vincent JL, Cook DJ, Cohen J, Dellinger RP, Opal S, Abraham E, Brett SJ, Smith T, et al.: Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis 190(3):527-534, 2004.
6. Fink MP, Delude RL: Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 21(2):177-196, 2005.
7. Singh S, Evans TW: Organ dysfunction during sepsis. Intensive Care Med 32:349-360, 2006.
8. Taveira da Silva AM, Kaulbach HC, Chuidian FS, Lambert DR, Suffredini AF, Danner RL: Brief report: shock and multiple-organ dysfunction after self-administration of Salmonella endotoxin. N Engl J Med 328(20):1457-1460, 1993.
9. Stephens RC, O'Malley CM, Frumento RJ, Mythen MG, Bennett-Guerrero E: Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers. J Endotoxin Res 11(4):207-212, 2005.
10. Coyle SM, Calvano SE, Lowry SF: Gender influences in vivo human responses to endotoxin. Shock 26(6):538-543, 2006.
11. Swank GM, Deitch EA: Role of the gut in multiple organ failure: bacterial translocation and permeability changes. World J Surg 20(4):411-417, 1996.
12. Danner RL, Elin RJ, Hosseini JM, Wesley RA, Reilly JM, Parillo JE: Endotoxemia in human septic shock. Chest 99(1):169-175, 1991.
13. Rassias AJ, Holzberger PT, Givan AL, Fahrner SL, Yeager MP: Decreased physiologic variability as a generalized response to human endotoxemia. Crit Care Med 33:512-519, 2005.
14. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ: Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23:1638-1652, 1995.
15. Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med 13:818-829, 1985.
16. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG: The sepsis-related organ failure assessment (SOFA) score to describe organ dysfunction/failure. Intensive Care Med 22:707-710, 1996.
17. Romaschin AD, Walker PM: Endotoxin activity in whole blood by neutrophil chemiluminescence - a novel analytical paradigm. Clin Chem 46(9):1504-1506, 2000.
18. Opal SM: The clinical relevance of endotoxin in human sepsis: a critical analysis. J Endotoxin Res 8(6):473-476, 2002.
19. Brock-Utne JG, Gaffin SL, Wells MT, Gathiram P, Sohar E, James MF, Morrell DF, Norman RJ: Endotoxaemia in exhausted runners after a long-distance race. S Afr Med J 73(9):533-536, 1988.
20. Hasday JD, Bascom R, Costa JJ, Fitzgerald T, Dubin W: Bacterial endotoxin is an active component of cigarette smoke. Chest 115(3):829-835, 1999.
21. Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP: Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation 12(5):255-269, 2005.
22. Kelly JL, O'Sullivan C, O'Riordain M: Is circulating endotoxin the trigger for the systemic inflammatory response syndrome seen after injury. Ann Surg 225(5):530-541, 1997.
23. Pape HC, Grotz M, Remmers D, Dwenger A, Vaske R, Wisner D, Tscherne H: Multiple organ failure (MOF) after severe trauma - a sheep model. Intensive Care Med 24(6):590-598, 1998.
24. Muenzer JT, Davis CG, Dunne BS, Unsinger J, Dunne WM, Hotchkiss RS: Pneumonia after cecal ligation and puncture: a clinically relevant "two hit" model of sepsis. Shock 26(6):565-570, 2006.
25. Opal SM, Gluck T: Endotoxin as a drug target. Crit Care Med 31(suppl 1): 57-64, 2003.
26. de Jonge E, Schultz MJ, Spanjaard L, Bossuyt PM, Vroom MB, Dankert J, Kesecioglu J: Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomized controlled trial. Lancet 362(9389):1011-1016, 2003.
27. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345(19):1368-1377, 2001.
28. Goldberger AL: Heartbeats, hormones, and health: is variability the spice of life? Am J Resp Crit Care Med 163(6):1289-1290, 2001.
29. Wysocki M, Cracco C, Teixeira A, Mercat A, Diehl JL, Lefort Y, Derenne JP, Similowski T: Reduced breathing variability as a predictor of unsuccessful patient separation from mechanical ventilation. Crit Care Med 34(8):2076-2083, 2006.
30. Shorr AF, Bernard GR, Dhainaut JF, Russel JR, Macias WL, Nelson DR, Sundin DP: Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome. Crit Care 15(10(3)):R92, 2006.
31. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY: Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 34(7):1996-2003, 2006.
32. Seely AJ, Macklem PT: Complex systems and the technology of variability analysis. Crit Care 8:R367-R384, 2004.