Multiple organ failure (MOF) after severe trauma - A sheep model

Intensive Care Medicine

Volumn 24, Issue 6, 1998, Pages 590-598

  Pape, H C ^a   Grotz, M ^a   Remmers, D ^a   Dwenger, A ^a   Vaske, R ^a   Wisner, D ^b   Tscherne, H ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endotoxin; Intramedullary femoral nailing; Large animal model; Multiple organ failure; Zymosan activated plasma

Indexed keywords

BILIRUBIN; CREATININE; ENDOTOXIN; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CREATININE CLEARANCE; FEMALE; HEART INDEX; HEMORRHAGIC SHOCK; INTRAMEDULLARY NAILING; LIVER FUNCTION; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; NONHUMAN; SHEEP; TIME;

EID: 0031927271     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001340050620     Document Type: Article

References (35)

1. Baue AE (1975) Multiple, progressive, or sequential system failure: a syndrome for the 1970s. Arch Surg 110: 779-788
2. Knaus WA, Wagner DP (1989) Multiple systems organ failure: epidemiology and prognosis. Crit Care Clin 5: 221-232
3. Chaudry IH, Wang P, Singh G, Hauptman JG, Ayla A (1993) Rat and mouse models of hypovolemic-traumatic shock. In: G Schlag, H Redl H (eds) Pathophysiology of shock, sepsis and organ failure. Springer, Berlin, New York, London, pp 371-392
4. Goris RJA, Boekholtz WKF, Van Bebber IPT, Nuytinck JKS, Schillings PHM (1986) Multiple organ failure and sepsis without bacteria. Arch Surg 121: 897-903
5. Pape H-C, Dwenger A, Regel G, Schweitzer G, Remmers D, Pape D, Sturm JA (1994) Pulmonary damage after recurrent administration of endotoxin and zymosan activated plasma - a sheep model. Theor Surg 9: 82-89
6. Pape H-C, Dwenger A, Regel G, Schweitzer G, Remmers D, Pape D, Sturm JA (1993) Hemorrhagic shock, endotoxin and complement activation induce late organ failure in sheep. Theor Surg 8: 21-28
7. Schlag G, Redl H, Davies J, Van Vuuren CCJ, Smuts P (1993) Live Escherichia coli sepsis models in Baboons. In: Schlag G, Redl H, (eds) Pathophysiology of shock, sepsis and organ failure. Springer Berlin, Heidelberg, New York, pp 1093-1107
8. Steinberg S, Flynn W, Kelley K, Sharma P, Hassett J, Price R, Flint L (1989) Development of a bacteria-independant model of the multiple organ failure syndrome. Arch Surg 124: 1390-1394
9. Bickhardt K (1987) Organ distribution pattern and plasma half-life times of diagnostically important enzymes in the sheep. Berl Münch Tierärztl Wochenschr 100: 155-161
10. Kox W, Schindler HG, Brug E (1979) Biochemische und histologische Veränderungen nach Trauma und Schock -tierexperimentelle Untersuchungen zur Pathogenese des akuten Lungenversagens und der sogenannten Fettembolie. Hefte Unfallheilkunde 138: 272-275
11. Rana MW, Sing G, Wang P (1992) Protective effects of preheparinzation on microvasculature during and following hemorrhagic shock. J Trauma 32: 420-425
12. Pretorius JP, Schlag G, Redl H (1987) The 'lung in shock' as a result of hypovolemic-traumatic shock. J Trauma 27: 1344-1352
13. Pape H-C, Regel G, Dwenger A, Sturm JA (1990) Does additional lung injury and hemorrhagic shock aggravate lung damage from intrameduallary nailing in sheep? Circ Shock 31: 54
14. Demling RH, Lalonde CC, Jin LJ, Albes J, Fiori N (1986) The pulmonary and systemic response to recurrent endotoxemia in the adult sheep. Surgery 100: 876-883
15. Lang CH, Spitzer J A (1987) Glucose kinetics and development of endotoxin tolerance during long-term endotoxin infusion. Metabolism 36: 469-474
16. Egan TM, Saunders NR, Luk SC, Cooper JD (1988) Complement mediated pulmonary edema in sheep. J Surg Res 45: 204-214
17. Doerschuk CM, Allard MF, Hogg JC (1989) Neutrophil kinetics in rabbits during infusion of zymosan activated plasma. J Appl Physiol 67: 88-95
18. Nuytinck JK, Goris RJ, Weerts JGE, Schillings PHM, Schurmanns JH (1986) Acute generalized microvascular injury by activated complement and hypoxia: the basis of the adult respiratory distress syndrome and multiple organ failure? Br J Exp Pathol 67: 548-553
19. Deitch EA, Berg RD (1987) Endotoxin but not malnutrition promotes bacterial translocation of the gut flora in burned mice. J Trauma 27, 2: 161-166
20. Regel G, Nerlich ML, Dwenger A, Sturm JA (1989) Induction of pulmonary injury by PMNL after bone marrow fat injection and endotoxemia: a sheep model. Theor Surg 4: 22-30
21. Pape H-C, Dwenger A, Regel G, Schweitzer G, Jonas M, Remmers D, Krumm K, Sturm JA, Tscherne H (1992) Pulmonary damage after intramedullary femoral nailing in traumatized sheep - is there any effect of different nailing methods? J Trauma 33: 574-578
22. Pape H-C, Regel G, Tscherne H (1996) Local and systemic effects of fat embolization after intramedullary reaming and its influence by cofactors. Techniques in Orthop 11, 1: 2-13
23. Pape H-C, Auf m'Kolck M, Paffrath T, Regel G, Sturm JA, Tscherne H (1993) Primary intramedullary femur fixation in multiple trauma patients with associated lung contusion - a cause of posttraumatic ARDS? J Trauma 34, 4: 540-548
24. Heideman M, Kaiser B, Gelin LE (1978) Complement activation by homogenized muscle tissue. J Surg Res 25: 518-523
25. Zilow O, Sturm JA, Rother U, Kirschfink M (1990) Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndrome. Clin Exp Immun 79: 151-155
26. Deitch EA, Ma WJ, Ma L (1989) Endotoxin-induced bacterial translocation: a study of mechanisms. Surgery 106: 300-302
27. Pape H-C, Regel G, Dwenger A, Schweitzer G, Krettek K, Sturm JA, Tscherne H (1993) Influences of different methods of intramedullary femoral nailing on lung function in patients with multiple trauma. J Trauma 35, 5: 709-715
28. Pape H-C, Dwenger A, Grotz, M, Kaever V, Negatsch R, Kleemann W, Sturm JA, Tscherne H (1994) Does the reamer type influence the degree of lung dysfunction after femoral nailing following severe trauma? An animal study. J Orthop Trauma 8, 4: 300-309
29. Wichterman KA, Baue AE, Chaudry IH (1980) Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res 29: 189-201
30. Goris RJ, Boeckhorst PA, Nuytinck KS (1985) Multiple organ failure: generalized autodestructive inflammation. Arch Surg 20: 1109-1120
31. Pape H-C, Remmers D, Kleemann W, Goris RJA, Tscherne H (1994) Posttraumatic multiple organ failure - a report on clinical and autopsy findings. Shock 1: 228-234
32. Pape H-C, Dwenger A, Regel G, Goollub F, Wisner D, Sturm JA, Tscherne H (1994) Increased gut permeability after multiple trauma. Br J Surg 81: 850-852
33. Chaudry IH, Blasko KA, Wagner PA (1989) A clinically relevant model of hemorrhagic shock and resuscitation in the rat. Circ Shock 27: 318-319
34. Dwenger A, Remmers D, Grotz M, Pape H-C, Gruner A, Jochum M, Regel G (1996) Aprotinin prevents the development of trauma induced MOF in a chronic sheep model. Eur J Clin Chem Clin Biochem 34, 3: 207-214
35. Remmers D, Dwenger A, Grotz M, Pape H-C, Gruner A, Regel G (1996) Attenuation of multiple organ dysfunction in a chronic sheep model by the 21-aminosteroid U74389 G. J Surg Res 62, 2: 278-273