CD4+/CD56+ hematodermic neoplasm: Presentation of 2 cases and review of the concept of an uncommon tumor originated in plasmacytoid dendritic cells expressing CD123 (IL-3 receptor α)

Applied Immunohistochemistry and Molecular Morphology

Volumn 15, Issue 4, 2007, Pages 481-486

  Piña Oviedo, Sergio ^a,b   Herrera Medina, Hector ^d   Coronado, Heliodoro ^e   Valle, Luis Del ^f   Ortiz Hidalgo, Carlos ^a,c  

^a UNIVERSIDAD PANAMERICANA   (Mexico)

^b Institute of Hematopathology 'The Anton Van Leeuwenhoek Society for Life and Exact Sciences'   (Mexico)

^c AMERICAN BRITISH COWDRAY MEDICAL CENTER   (Mexico)

^d General Hospital of Culiacan   (Mexico)

^e Hospital General Aranda de la Parra   (Mexico)

^f TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blastic NK cell lymphoma; CD 123; CD4 + CD56 + hematodermic neoplasm; Interleukin 3 receptor ; Plasmacytoid dendritic cell

Indexed keywords

CD123 ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CASE REPORT; CD4 CD56 HEMATODERMIC NEOPLASM; CLINICAL FEATURE; CONTROLLED STUDY; DENDRITIC CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEOPLASM; PRIORITY JOURNAL;

ADULT; AGED; ANTIGENS, CD4; ANTIGENS, CD56; DENDRITIC CELLS; HEMATOLOGIC NEOPLASMS; HUMANS; INTERLEUKIN-3 RECEPTOR ALPHA SUBUNIT; MALE; SKIN NEOPLASMS;

EID: 37349072826     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/01.pai.0000213139.39654.40     Document Type: Article

References (50)

1. Brody J, Allen S, Schulman P, et al. Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducting agents. Cancer. 1995;75:2474-2483.
2. Willemze R, Jaffe E, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768-3785.
3. + malignancies. Blood. 2002;99:1556-1563.
4. Petrella T, Wechsler J, Courville P, et al. Hematodermic CD4/CD56 neoplasm. Ann Pathol. 2004;24:241-255.
5. Chan JK, Jaffe ES, Ralfkiaer E. Blastic NK-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, et al, eds. World Health Organization Classification of Tumours: Pathology & Genetics. Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001: 214-215.
6. Chaperot L, Bendriss N, Manches O, et al. Identification of a leukemic counterpart of the plasmacytoid dendritic cells. Blood. 2001;97:3210-3217.
7. + blastic tumors of skin. Blood. 2003;101:5007-5009.
8. + lineage negative malignancies: a new entity developed from malignant early plasmacytoid dendritic cells. J Hematol. 2003;88:941-955.
9. + cutaneous neoplasms: a distinct hematological entity? Am J Surg Pathol. 1999;23:137-146.
10. Nava V, Jaffe E. The pathology of NK-cell lymphomas and leukemias. Adv Anat Pathol. 2005;12:27-34.
11. Massone C, Chott A, Metze D, et al. Subcutaneous, blastic natural killer (NK), NK/T-cell, and other cytotoxic lymphomas of the skin. Am J Surg Pathol. 2004;28:719-735.
12. Reichard K, Burks E, Foucar M, et al. CD4(+) CD56(+) lineage-negative malignancies are rare tumors of plasmacytoid dendritic cells. Am J Surg Pathol. 2005;29:1274-1283.
13. Brière F, Bendriss-Vermare N, Delale T, et al. Origin and filiation of human plasmacytoid dendritic cells. Hum Immunol. 2002;63:1081-1093.
14. Vandenabeele S, Wu L. Dendritic cell origins: puzzles and paradoxes. Immunol Cell Biol. 1999;77:411-419.
15. McKenna K, Beignon A, Bhardwaj N. Plasmacytoid dendritic cells: linking innate and adaptive immunity. J Virol. 2005;79:17-27.
16. Khoury J, Medeiros L, Manning J, et al. CD56(+) TdT (+) blastic natural killer cell tumor of the skin: a primitive systemic malignancy related to myelomonocytic leukemia. Cancer. 2002;94:2401-2408.
17. Mukai H, Kojima H, Suzukawa K, et al. High-dose chemotherapy with peripheral blood stem cell rescue in blastoid natural killer cell lymphoma. Leuk Lymphoma. 1999;32:583-588.
18. Kojima H, Mukai H, Shinagawa A, et al. Clinicopathological analyses of 5 Japanese patients with CD56+ primary cutaneous lymphomas. Int J Hematol. 2000;72:477-483.
19. Mhawech P, Medeiros L, Bueso-Ramos C, et al. Natural killer-cell lymphoma involving the gynecologic tract. Arch Pathol Lab Med. 2000;124:1510-1513.
20. Nagatani T, Okazawa H, Kambara T, et al. Cutaneous monomorphous CD4- and CD56-positive large cell lymphoma. Dermatol. 2000;200:202-208.
21. Beiske K, Langholm R, Godal T, et al. T-zone lymphoma with predominance of 'plasmacytoid T-cells' associated with myelomonocytic leukaemia - a distinct clinicopathological entity. J Pathol. 1986;150:247-255.
22. Prasthofer E, Prchal J, Grizzle W, et al. Plasmacytoid T cell-lymphoma associated with chronic proliferative disorder. Am J Surg Pathol. 1985;9:380-387.
23. Baddoura F, Hanson C, Chan W. Plasmacytoid monocyte proliferation associated with myeloproliferative disorders. Cancer. 1992;69:1457-1467.
24. Lennert K, Remmele W. Karyometrische untersuchungen an lymphknotenzellen des menschen. I. Mitteilung: germinoblasten, lymphoblasten und lymphozyten. Acta Haematol. 1958;19:99-113.
25. Lubarsch O, Henke F, Rössle R, et al. Handbuch der speziellen pathologischen Anatomie und Histologie. Vol 1/3 A. Berlin: Springer-Verlag; 1961.
26. Lennert K, Kaiserling E, Müller-Hermelink H. T-associated plasma cells. Lancet. 1975;1:1031-1032.
27. Lennert K, Stein H, Müller-Hermelink J, et al. T cells with plasmacytoid features. In: Bernard A, Boumsell L, Dausset J, et al, eds. Leukocyte Typing. Human Leukocyte Differentiation Antigens Detected by Monoclonal Antibodies. Berlin: Springer-Verlag; 1984.
28. Grouard G, Rissoan M, Filgueira L, et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD-40-ligand. J Exp Med. 1997;185:1101-1111.
29. Papadimitriou C, Stephanaki-Nikou S, Malamou-mitsi V. Comparative immunostaining of T-cell associated plasma cells and other lymph-node cells in paraffin section. Virchows Arch (Cell Pathol). 1983;43:31-36.
30. Steinman R. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol. 1991;9:271-296.
31. + T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood. 2003;101:3520-3526.
32. Abb J, Abb H, Deinhardt F. Phenotype of human alpha-interferon producing leukocytes identified by monoclonal antibodies. Clin Exp Immunol. 1983;52:179-184.
33. Chehimi J, Starr S, Kawashima H, et al. Dendritic cells and IFN-alpha-producing cells are two functionally distinct non-B, nonmonocytic HLA-DR+ cell subsets in human peripheral blood. Immunology. 1989;68:488-490.
34. Fitzgerald-Bocarsly P. Human natural interferon-alpha producing cells. Pharmacol Ther. 1993;60:39-62.
35. Lore K, Smed-Sorensen A, Vasudevan J, et al. Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells. J Exp Med. 2005;201:2023-2033.
36. Hartmann E, Wollenberg B, Rothenfusser S, et al. Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res. 2003;93:6478-6487.
37. Salio M, Cella M, Vermi W, et al. Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions. Eur J Immunol. 2003;33:1052-1062.
38. Vermi W, Bonecchi R, Facchetti F, et al. Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas. J Pathol. 2003;200:255-268.
39. Zou W, Machelon V, Coulomb-L'Hermin A, et al. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med. 2001;7:1339-1346.
40. DiGiuseppe J, Louie D, Williams J, et al. Blastic natural killer cell leukemia/ lymphoma: a clinicopathologic study. Am J Surg Pathol. 1997;21:1223-1230.
41. + "lymphoma": report of two cases and review of the literature. Am J Clin Pathol. 1998;110:478-488.
42. Slater D. The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. Br J Dermatol. 2005;153:874-880.
43. + hematological neoplasms presenting in the skin: a retrospective analysis of 23 new cases and 130 cases from the literature. Ann Oncol. 2004;15:1097-1108.
44. + DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Français de Cytogénétique Hématologique. Blood. 2002;99:4154-4159.
45. Kanazawa N, Tashiro K, Mivachi Y. Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2. Immunobiol. 2004;209:179-190.
46. Urosevic M, Conrad C, Kamarashev J, et al. CD4+CD56+ hematodermic neoplasms bear a plasmacytoid dendritic cell phenotype. Hum Pathol. 2005;36:1020-1024.
47. Muñoz L, Nomdedéu J, López O, et al. Interleukin-3 receptor α chain (CD123) is widely expressed in hematologic malignancies. Haematologica. 2001;86:1261-1269.
48. Jordan C, Upchurch D, Szilvassy S, et al. The interleukin-3 receptor a chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000;14:1777-1784.
49. Ransohoff R. Cellular responses to interferons and other cytokines: the JAK/STAT paradigm. N Engl J Med. 1998;338:616-618.
50. Petrella T, Comeau M, Maynadié M, et al. 'Agranular CD4+ CD56+ hematodermic neoplasm' (blastic NK-cell lymphoma) originates from a population of CD56+ precursor cells related to plasmacytoid monocytes. Am J Surg Pathol. 2002;26:852-862.