Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias

Pediatric and Developmental Pathology

Volumn 10, Issue 6, 2007, Pages 446-454

  Liu, Benchun ^a   Lin, Guiting ^a   Willingham, Emily ^a   Ning, Hongxiu ^a   Lin, Ching Shwun ^a   Lue, Tom F ^a   Baskin, Laurence S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATF3; Congenital abnormality; Endocrine disruption; Estradiol; Hypospadias

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ETHINYLESTRADIOL; LUCIFERASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOCRINE DISEASE; ENZYME ACTIVITY; EPITHELIUM; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOSPADIAS; IMMUNOCYTOCHEMISTRY; MESENCHYME; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PREPUCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

EID: 37349069521     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/06-04-0079.1     Document Type: Article

References (17)

1. Baskin LS. Hypospadias. Adv Exp Med Biol 2004;545:3-22.
2. Baskin LS, Himes K, Colborn T. Hypospadias and endocrine disruption: is there a connection? Environ Health Perspect 2001;109:1175-1183.
3. Steinhardt GF. 2004. Endocrine disruption and hypospadias. Adv Exp Med Biol 545:203-215.
4. Baskin LS, Erol A, Jegatheesan P, Li Y, Liu W, Cunha GR. Urethral seam formation and hypospadias. Cell Tissue Res 2001;305:379-387.
5. Suzuki K, Ogino Y, Murakami R, Satoh Y, Bachiller D, Yamada G. Embryonic development of mouse external genitalia: insights into a unique mode of organogenesis. Evol Dev 2002;4:133.
6. Liu B, Wang Z, Lin G, et al. Activating transcription factor 3 is upregulated in patients with hypospadias. Pediatr Res 2005;58(6):1280-1283.
7. Liu B, Agras K, Willingham E, Vilela MLB, Baskin LS. Activating transcription factor 3 is estrogen responsive in utero and upregulated during sexual differentiation. Horm Res 2006;65:217-222.
8. Inoue A, Yoshida N, Omoto Y, et al. Development of cDNA microarray for expression profiling of estrogen-responsive genes. J Mol Endocrinol 2002;29:175-192.
9. Pedram A, Razandi M, Aitkenhead M, Hughes CC, Levin ER. Integration of the non-genomic and genomic actions of estrogen membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem 2002;277:50768-50775.
10. Li J, Willingham E, Baskin LS. Gene expression profiles in mouse urethral development. BJU Int 2006;98(4):880-885.
11. Valcourt U, Kowanetz M, Niimi H, Heldin C-H, Moustakas A. TGF-B and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 2005;16(4):1987-2002.
12. Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev 2005;19(23):2783-2810.
13. Kang Y, Chen C-R, Massague J. A self-enabling TGFB response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003;11(4):915-926.
14. Matsuda T, Tamamoto T, Muraguchi A, Saatcioglu F. Cross-talk between transforming growth factor-B and estrogen receptor signaling through Smad3. J Biol Chem 2001;276(46):42908-42914.
15. Tomic D, Miller KP, Kenny HA, Woodruff TK, Hoyer P, Flaws JA. Ovarian follicle development requires Smad3. Mol Endocrinol 2004;18(9):2224-2240.
16. Murakami R. A histological study of the development of the penis of wild-type and androgen-insensitive mice. J Anat 1987;153:22316.
17. Kurzrock EA, Baskin LS, Li Y, Cunha GR. Epithelial-mesenchymal interactions in development of the mouse fetal genital tubercle. Cells Tissues Organs 1999;164(3):125-130.