Activating transcription factor 3 is estrogen-responsive in utero and upregulated during sexual differentiation

Hormone Research

Volumn 65, Issue 5, 2006, Pages 217-222

  Liu, Benchun ^a   Agras, Koray ^a   Willingham, Emily ^a   Vilela, Marcelo L B ^a   Baskin, Laurence S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Activating transcription factor 3; Endocrine disrupters; Estrogen; Genitourinary abnormalities; Hypospadias; Sex differentiation; Transcription factor

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; COMPLEMENTARY DNA; ENDOCRINE DISRUPTOR; ESTROGEN; ETHINYLESTRADIOL; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESTROGEN ACTIVITY; GENE EXPRESSION REGULATION; HORMONE ACTION; HYPOSPADIAS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENTIATION; URETHRA MALFORMATION;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPOSPADIAS; IMMUNOHISTOCHEMISTRY; MALE; MICE; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX DIFFERENTIATION; UP-REGULATION; URETHRA;

EID: 33646088731     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000092402     Document Type: Article

References (12)

1. Baskin LS: Hypospadias. Adv Exp Med Biol 2004;545:3-22.
2. Paulozzi LJ, Lary JM: Laterality patterns in infants with external birth defects. Teratology 1999;60:265-271.
3. Baskin LS, Himes K, Colborn T: Hypospadias and endocrine disruption: is there a connection? Environ Health Perspect 2001;109: 1175-1183.
4. Baskin LS, Erol A, Jegatheesan P, Li Y, Liu W, Cunha GR: Urethral seam formation and hypospadias. Cell Tissue Res 2001;305:379-387.
5. Baskin LS, Liu W, Bastacky J, Yucel S: Anatomical studies of the mouse genital tubercle. Adv Exp Med Biol 2004;545:103-121.
6. Steinhardt GF: Endocrine disruption and hypospadias. Adv Exp Med Biol 2004;545:203-215.
7. Inoue A, Yoshida N, Omoto Y, Oguchi S, Yamori T, Kiyama R, Hayashi S: Development of cDNA microarray for expression profiling of estrogen-responsive genes. J Mol Endocrinol 2002;29:175-192.
8. Pedram A, Razandi M, Aitkenhead M, Hughes CC, Levin ER: Integration of the non-genomic and genomic actions of estrogen membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem 2002;277:50768-50775.
9. Liu B, Wang Z, Lin G, Agras K, Ebbers M, Willingham E, Baskin LS: Activating transcription factor 3 is upregulated in patients with hypospadias. Pediatr Res 2005;58:1280-1283.
10. Kim KS, Torres CR Jr, Yucel S, Raimondo K, Cunha GR, Baskin LS: Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens. Environ Res 2004;94: 267-275.
11. Fan F, Jin S, Amundson SA, Tong T, Fan W, Zhao H, Zhu X, Mazzacurati L, Li X, Petrik KL, Fornace AJ Jr, Rajasekaran B, Zhan Q: ATF3 induction following DNA damage is regulated by distinct signaling pathways and overexpression of ATF3 protein suppresses cells growth. Oncogene 2002;21:7488-7496.
12. Baskin LS: Hypospadias and urethral development. J Urol 2000;163:951-956.