Synaptosomal GABA uptake decreases in paraoxon-treated rat brain

Toxicology

Volumn 244, Issue 1, 2008, Pages 42-48

  Mohammadi, Moslem ^a   Ghani, Esmaeel ^a   Ghasemi, Asghar ^b   Khoshbaten, Ali ^a   Asgari, Alireza ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

GABA uptake; Paraoxon; Seizure; Synaptosome

Indexed keywords

2,4 DIAMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID CARRIER; ACETYLCHOLINESTERASE; PARAOXON; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SYNAPTOSOME;

ACETYLCHOLINESTERASE; ANIMALS; BETA-ALANINE; BRAIN; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; FASCICULATION; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; MALE; NIPECOTIC ACIDS; PARAOXON; RATS; RATS, WISTAR; SALIVATION; SYNAPTOSOMES; TEARS; TIME FACTORS; TREMOR; TRITIUM; URINATION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 37349065157     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.10.024     Document Type: Article

References (32)

1. B receptors. Physiol. Rev. 84 (2004) 835-867
2. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Cecchini A.L., Soares A.M., Giglio J.R., Amara S., and Arantes E.C. Inhibition of l-glutamate and GABA synaptosome uptake by crotoxin, the major neurotoxin from crotalus durissus terrificus venum. J. Venom Anim. Toxins. Incl. Trop. Dis. 10 3 (2004) 260-279
4. Clegg D.J., and van Gemert M. Determination of the reference dose for chlorpyrifos: preceedings of an expert panel. J. Toxicol. Environ. Health 2 (1999) 211-255
5. Conti F., Minelli A., and Melone M. GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications. Brain Res. Rev. 45 (2004) 196-212
6. Costa M.S., Rocha J.B.T., Perosa S.R., Cavalheiro E.A., and Naffah-Mazzacoratti M.G. Pilocarpine-induced status epilepticus increases glutamate release in rat hippocampal synaptosomes. Neurosci. Lett. 356 (2004) 41-141
7. Coudray-Lucas C., Prioux-Guyonneau M., Sentenac H., Cohen Y., and Wepierre J. Effects of physostigmine, paraoxon and soman on brain GABA level and metabolism. Acta Pharmacol. Toxicol. 55 (1984) 153-157
8. Dalby N.O. Inhibition of γ-aminobutyric acid uptake: anatomy, physiology, and effects against epileptic seizures. Eur. J. Pharmacol. 479 (2003) 127-137
9. Ellman G.L., Courtney K.D., Andres Jr. V., and Featherstone R.M. A new rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
10. Fosbraey P., Wetherell J.R., and French M.C. Neurotransmitter changes in guinea pig brain regions following soman intoxication. J. Neurochem. 54 (1990) 72-79
11. Ghasemi A., Sadidi A., Mohammadi M., Khoshbaten A., and Asgari A. Paraoxon inhibits GABA uptake in brain synaptosomes. Toxicol. In Vitro 21 8 (2007) 1499-1504
12. Harrison P.K., Sheridan R.D., Green A.C., Scott I.R., and Tattersall J.E.H. A guinea pig hippocampal slice model of organophosphate-induced seizure activity. J. Pharmacol. Exp. Ther. 310 2 (2004) 678-686
13. Karr P.P., and Matin M.A. Possible role of γ-aminobutyric acid in paraoxon-induced convulsions. J. Pharm. Pharmacol. 24 (1972) 996-997
14. Lallement G., Carpentier P., Collet A., Pernot-Marino I., Baubichon D., and Blanchet G. Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus. Brain Res. 563 (1991) 234-240
15. Liu D.D., Ueno E., Ho I.K., and Hoskins B. Evidence that alterations in γ-aminobutyric acid and acetylcholine in rat striata and cerebella are not related to soman-induced convulsions. J. Neurochem. 51 (1988) 181-187
16. McDonough J.H., and Shih T.M. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci. Biobehav. Rev. 21 5 (1997) 559-579
17. Minelli A., Debiasi S., Brecha N.C., Zuccarello L.V., and Conti F. GAT-3, a high-affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex. J. Neurosci. 16 19 (1996) 6255-6264
18. Padilla S., Wilson V.Z., and Bushnell P.J. Studies on the correlation between blood cholinesterase inhibition and target tissue inhibition in pesticide-treated rats. Toxicology 92 (1994) 11-25
19. Patrylo P.R., Spencer D.D., and Williamson A. GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. J. Neurophysiol. 85 (2001) 1533-1542
20. Pope C.N., Chakraborti T.K., Chapman M.L., Farrar J.D., and Arthun D. Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides. Toxicology 68 (1991) 51-61
21. Raiteri L., giovedi S., Benfenati F., Raiteri M., and Bonanno G. Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex. Neuropharmacology 44 (2003) 390-402
22. Rocha E.S., Swanson K.L., Aracava Y., Goolsby J.E., Maelicke A., and Albuquerque E.X. Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons. J. Pharmacol. Exp. Ther. 278 (1996) 1175-1187
23. Rump S., and Kowalczyk M. Management of convulsions in nerve agent acute poisoning: a polish perspective. J. Med. Chem. Def. 1 (2004) 1-14
24. Santos M.D., Pereira E.F.R., Aracava Y., Castro N.G., Fawcett W.P., Randall W.R., and Albuquerque E.X. Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvment of muscarinic receptors. J. Pharmacol. Exp. Ther. 304 1 (2002) 254-265
25. Shahroukhi A., Ghasemi A., Poorabdolhossein F., Asgari A., and Khoshbaten A. The effect of paraoxon on GABA uptake in rat cerebellar synaptosomes. Med. Sci. Monit. 13 9 (2007) 194-199
26. Shih T.M., and McDonough J.H. Neurochemical mechanisms in soman-induced seizures. J. Appl. Toxicol. 17 4 (1997) 255-264
27. Shih T.M., Koviak T.A., and Capacio B.R. Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neurosci. Biobehav. Rev. 15 3 (1991) 349-362
28. Sutch R.J., Davies C.C., and Bowery N.G. GABA release and uptake measured in crude synaptosomes from genetic absence epilepsy rats from Strasbourg (GAERS). Neurochem. Int. 34 (1999) 415-425
29. Szilagyi M., Gray P.J., and Dawson R.M. Effects of the nerve agents soman and tabun on the uptake and release of GABA and glutamate in synaptosomes of guinea pig cerebral cortex. Gen. Pharmacol. 24 3 (1993) 663-668
30. Tonduli L.S., Testylier G., Masqueliez C., Lallement G., and Monmaur P. Effects of huperzine used as pretreatment against soman-induced seizures. Neurotoxicology 22 (2001) 29-37
31. Ueda Y., and Willmore L.J. Hippocampal γ-aminobutyric acid transporter alterations following focal epileptogenesis induced in rat amygdale. Brain Res. Bull. 52 5 (2000) 357-361
32. 3H GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacology 23 (2000) 188-197