Left right asymmetry, the pulmonary vein, and A-fib

Circulation Research

Volumn 101, Issue 9, 2007, Pages 853-855

  Martin, James F ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Atrial fibrillation; Left right asymmetry; Pulmonary vein

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR PITX1; TRANSCRIPTION FACTOR PITX2; TRANSCRIPTION FACTOR PITX3; UNCLASSIFIED DRUG;

ANGIOGENESIS; CONGENITAL HEART MALFORMATION; DISEASE ASSOCIATION; EDITORIAL; EMBRYO DEVELOPMENT; GENETIC ASSOCIATION; HEART ATRIUM FIBRILLATION; HEART DEVELOPMENT; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PULMONARY VEIN;

ANIMALS; ATRIAL FIBRILLATION; HEART ATRIA; HOMEODOMAIN PROTEINS; HUMANS; PULMONARY CIRCULATION; PULMONARY VEINS; TRANSCRIPTION FACTORS;

EID: 37349065126     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.164079     Document Type: Editorial

References (27)

1. Haissaguerre M, Jais P, Shah DC, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med. 1998;339:659-666.
2. Mommersteeg MT, Brown NA, Prall OW, et al. Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ Res. 2007;101:902-909.
3. Gudbjartsson DF, Arnar DO, Helgadottir A, et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007;448:353-357.
4. Millino C, Sarinella F, Tiveron C, et al. Cardiac and smooth muscle cell contribution to the formation of the murine pulmonary veins. Dev Dyn. 2000;218:414-425.
5. Buckingham M, Meilhac S, Zaffran S. Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet. 2005;6:826-835.
6. Liu C, Liu W, Palie J, et al. Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002;129:5081-5091.
7. Schneitz K, Spielmann P, Noll M. Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. Genes Dev. 1993;7:114-129.
8. Gage PJ, Suh H, Camper SA. The bicoid-related Pitx gene family in development. Mamm Genome. 1999;10:197-200.
9. Semina EV, Ferrell RE, Mintz-Hittner HA, c17 Bitoun P, Alward WL, Reiter RS, Funkhauser C, Daack-Hirsch S, Murray JC. A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. Nat Genet. 1998;19:167-170.
10. Semina EV, Reiter R, Leysens NJ, c17 Alward WL, Small KW, Datson NA, Siegel-Bartelt J, Bierke-Nelson D, Bitoun P, Zabel BU, Carey JC, Murray JC. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet. 1996;14:392-399.
11. Shapiro MD, Marks ME, Peichel CL, et al. Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Nature. 2004;428:717-723.
12. Brown NA, Anderson RH. Symmetry and laterality in the human heart: developmental implications. In: Harvey RP, Rosenthal N, eds. Heart Development. San Diego, Ca: Academic Press;1999;:447-462.
13. Brueckner M. Cilia propel the embryo in the right direction. Am J Med Genet. 2001;101:339-344.
14. Hamada H, Meno C, Watanabe D, c17 Saijoh Y. Establishment of vertebrate left-right asymmetry. Nat Rev Genet. 2002;3:103-113.
15. Shiratori H, Yashiro K, Shen MM. Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development. 2006;133:3015-3025.
16. Campione M, Ros MA, Icardo JM, et al. Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice. Dev Biol. 2001;231:252-264.
17. Logan M, Pagan-Westphal SM, Smith DM, et al. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell. 1998;94:307-317.
18. Ryan AK, Blumberg B, Rodriguez-Esteban C, et al. Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature. 1998;394:545-551.
19. Campione M, Steinbeisser H, Schweickert A, et al. The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development. 1999;126:1225-1234.
20. Franco D, Campione M, Kelly R, c17 Zammit PS, Buckingham M, Lamers WH, Moorman AF. Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart. Circ Res. 2000;87:984-991.
21. Liu C, Liu W, Lu MF, , . Regulation of left-right asymmetry by thresholds of Pitx2c activity. Development. 2001;128:2039 -2048.
22. Kitamura K, Miura H, Miyagawa-Tomita S, et al. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Development. 1999;126:5749-5758.
23. Kioussi C, Briata P, Baek SH, et al. Identification of a Wnt/Dvl/beta-Catenin -> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell. 2002;111:673-685.
24. Martinez-Fernandez S, Hernandez-Torres F, Franco D, et al. Pitx2c overexpression promotes cell proliferation and arrests differentiation in myoblasts. Dev Dyn. 2006;235:2930-2939.
25. Ai D, Liu W, Ma L, et al. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol. 2006;296:437-449.
26. Schott JJ, Benson DW, Basson CT, et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science. 1998;281:108-111.
27. Moskowitz IP, Kim JB, Moore ML, et al. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell. 2007;129:1365-1376.