Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats

Brazilian Journal of Medical and Biological Research

Volumn 40, Issue 11, 2007, Pages 1481-1493

  Pesic V ^a   Radojevic K ^b   Kosec, D ^b   Plecas Solarovic B ^a   Perisi M ^b   Pilipovic I ^b   Leposavić, Gordana ^a,b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Inst of Immunol and Virol Torlak   (Serbia)

Author keywords

Aging; Orchidectomy; Rat thymus; Stereological analysis; Thymocyte apoptosis; Thymocyte proliferation

Indexed keywords

SEX HORMONE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CASTRATION; CELL COMPOSITION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; HORMONE ACTION; IMMUNOPATHOLOGY; INVOLUTION; MALE; MITOSIS RATE; MORPHOMETRICS; NONHUMAN; ORCHIECTOMY; ORGAN WEIGHT; PUBERTY; RAT; SIGNAL TRANSDUCTION; STEREOMETRY; THYMOCYTE; THYMUS ATROPHY;

RATTUS;

EID: 37349035352     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/s0100-879x2006005000172     Document Type: Article

References (40)

1. Grossman CJ. Interactions between the gonadal steroids and the immune system. Science 1985; 227: 257-261.
2. Bodey B, Bodey B Jr, Siegal SE, Kaiser HE. Involution of the mammalian thymus, one of the leading regulators of aging. In Vivo 1997; 11: 421-440.
3. Quaglino D, Capri M, Bergamini G, Euclidi L, Zecca L, Ronchetti IP. Age-dependent remodeling of rat thymus. Morphological and cytofluorimetric analysis from birth up to one year of age. Eur J Cell Biol 1998; 76: 156-166.
4. Pawelec G, Effros RB, Caruso C, Remarque E, Barnett Y, Solana R. T cells and aging (update February 1999). Front Biosci 1999; 4: D216-D269.
5. Viselli SM, Olsen NJ, Shults K, Steizer G, Kovacs WJ. Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes. Mol Cell Endocrinol 1995; 109: 19-26.
6. Olsen NJ, Olson G, Viselli SM, Gu X, Kovacs WJ. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 2001; 142: 1278-1283.
7. Kendall MD, Fitzpatrick FT, Greenstein BD, Khoylou F, Safieh B, Hamblin A. Reversal of ageing changes in the thymus of rats by chemical or surgical castration. Cell Tissue Res 1990; 261: 555-564.
8. Leposavić G, Pejcić-Karapetrović B, Kosec D. Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age. Mech Ageing Dev 2002; 123: 401-411.
9. Steinmann GG, Klaus B, Muller-Hermelink HK. The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 1985; 22: 563-575.
10. Min H, Montecino-Rodriguez: E, Dorshkind K. Reassessing the role of growth hormone and sex steroids in thymic involution. Clin Immunol 2006; 118: 117-123.
11. Plećaš-Solarović B, Lalić Lj, Leposavić G. Age-dependent morphometrical changes in the thymus of male propranolol-treated rats. Ann Anat 2004; 186: 141-147.
12. Lind EF, Prockop SE, Porritt HE, Petrie HT. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J Exp Med 2001; 194: 127-134.
13. Kendall MD, AI-Shawaf AA. Innervation of the rat thymus gland. Brain Behav Immun 1991; 5: 9-28.
14. Leposavić G, Pešić V, Kosec D, Radojević K, Arsenović-Ranin N, Pilipović,, et al. Age-associated changes in CD90 expression on thymocytes and in TCR-dependent stages of thymocyte maturation in male rats. Exp Gerontol 2006; 41: 574-589.
15. Kamath AB, Nagarkatti PS, Nagarkatti M. Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its affect on apoptosis. Toxicol Appl Pharmacol 1998; 150: 117-124.
16. Laakko T, King L, Fraker P. Versatility of merocyanine 540 for the flow cytometric detection of apoptosis in human and murine cells. J Immunol Methods 2002; 261: 129-139.
17. Mower DA Jr, Peckham DW, Illera VA, Fishbaugh JK, Stunz LL, Ashman RF. Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis. J Immunol 1994; 152: 4832-4842.
18. Ormerod MG. Investigating the relationship between the cell cycle and apoptosis using flow cytometry. J Immunol Methods 2002; 265: 73-80.
19. Cohen JJ. Programmed cell death in the immune system. Adv Immunol 1991; 50: 55-85.
20. Hale LP, Clark AG, Li J, Greer PK, Byers Kraus V. Age-related thymic atrophy in the guinea pig. Dev Comp Immunol 2001; 25: 509-518.
21. Nabarra B, Andrianarison I. Ultrastructural study of thymic microenvironment involution in aging mice. Exp Gerontol 1996; 31: 489-506.
22. Lau LL, Spain LM. Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice. Mech Ageing Dev 2000; 114: 101-121.
23. Li L, Hsu HC, Grizzle WE, Stockard CR, Ho KJ, Lott P, et al. Cellular mechanism of thymic involution. Scand J Immunol 2003; 57: 410-422.
24. Plećaš-Solarović B, Pešić V, Radojević K, Leposavić G. Morphometrical characteristics of age-associated changes in the thymus of old male Wistar rats. Anat Histol Embryol 2006; 35: 380-386.
25. Ishimi Y, Yoshida M, Wakimoto S, Wu J, Chiba H, Wang X, et al. Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice. Bone 2002; 31: 180-185.
26. Gill J, Malin M, Sutherland J, Gray D, Hollander G, Boyd R. Thymic generation and regeneration. Immunol Rev 2003; 195: 28-50.
27. Windmill KF, Lee VW. Influences of surgical castration on the thymus of male rats. J Reprod Immunol 1999; 44: 29-39.
28. Olsen NJ, Viselli SM, Fan J, Kovacs WJ. Androgens accelerate thymocyte apoptosis. Endocrinology 1998; 139: 748-752.
29. Olsen NJ, Viselli SM, Shults K, Stelzer G, Kovacs WJ. Induction of immature thymocyte proliferation after castration of normal male mice. Endocrinology 1994; 134: 107-113.
30. Guevara Patino A Marino MW, Ivanov VN, Nikolich-Zugich J. Sex steroids induce apoptosis of CD8+CD4+ double-positive thymocytes via TNF-alpha. Eur J Immunol 2000; 30: 2586-2592.
31. Zhou Z, Shackleton CH, Pahwa S, White PC, Speiser PW. Prominent sex steroid metabolism in human lymphocytes. Mol Cell Endocrinol 1998; 138: 61-69.
32. Khosla S, Ovalle WK. Morphology and distribution of cystic cavities in the normal murine thymus. Cell Tissue Res 1986; 246: 531-542.
33. Sakabe K, Kawashima I, Urano F, Seiki K, Itoh T. Effects of sex steroids on the proliferation of thymic epithelial cells in a culture model: a role of protein kinase C. Immunol Cell Biol 1994; 72: 193-199.
34. van Weerden WM, Bierings HG, van Steenbrugge GJ, de Jong FH, Schroder FH. Adrenal glands of mouse and rat do not synthesize androgens. Life Sci 1992; 50: 857-861.
35. Belanger B, Belanger A, Labrie F, Dupont A, Cusan L, Monfette G. Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men. J Steroid Biochem 1989; 32: 695-698.
36. Kelley KW, Brief S, Westly HJ, Novakofski J, Bechtel PJ, Simon J, et al. GH3 pituitary adenorna cells Gan reverse thymic aging in rats. Proc Natl Acad Sci USA 1986; 83: 5663-5667.
37. Montecino-Rodriguez E, Clark R, Dorshkind K. Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice. Endocrinology 1998; 139: 4120-4126.
38. Kaler LW, Neaves; WB. The androgen status of aging male rats. Endocrinology 1981; 108: 712-719.
39. Taub DD, Longo DL. Insights into thymic aging and regeneration. Immunol Rev 2005; 205: 72-93.
40. Utsuyama M, Hirokawa K. Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy. Mech Ageing Dev 1989; 47: 175-185.