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We examined one-pot methylation of the resulting enolate in the Michael addition, but the results were fruitless. The reaction did not completed even by the addition of large excess of MeI, and separation of 7a and 10a was difficult.
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The stereochemistry was confirmed by nuclear Overhauser effect (NOE) experiments. The NOE was observed between two methine protons beside the THF oxygen and one of two methine protons bearing methyl group. It was also observed between another methine proton bearing the methyl group and the aryl proton.
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