Trypanocidal constituents in plants 1. Evaluation of some Mexican plants for their trypanocidal activity and active constituents in Guaco, roots of Aristolochia taliscana

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 9, 2002, Pages 1188-1191

  Abe, Fumiko ^a   Nagafuji, Shinya ^a   Yamauchi, Tatsuo ^a   Okabe, Hikaru ^a   Maki, Jun ^b   Higo, Hiroo ^c   Akahane, Hiroshige ^a   Aguilar, Abigail ^d   Jiménez Estrada, Manuel ^e   Reyes Chilpa, Ricardo ^e  

^a FUKUOKA UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^e UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Aristolochia taliscana; Chagas' disease; Lignan; Neolignan; Trypanocidal activity; Trypanosoma cruzi

Indexed keywords

ARISTOLOCHIA TALISCANA EXTRACT; BERBERINE; GOSSYPOL; HARMINE; NEOLIGNAN; PLANT EXTRACT; UNCLASSIFIED DRUG; ANTITRYPANOSOMAL AGENT;

ARTICLE; BIOASSAY; CHAGAS DISEASE; CONTROLLED STUDY; EXTRACTION; FRACTIONATION; IMMOBILIZATION; NONHUMAN; PLANT ROOT; TRYPANOSOMA CRUZI; ANIMAL; ARISTOLOCHIA; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; DRUG SCREENING; HUMAN; ISOLATION AND PURIFICATION; METHODOLOGY; MEXICO; MIKANIA;

ANIMALS; ARISTOLOCHIA; DRUG EVALUATION, PRECLINICAL; HUMANS; MEXICO; MIKANIA; PLANT EXTRACTS; PLANT ROOTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 10844291505     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.1188     Document Type: Article

References (22)

1. WHO Tropical Disease Research: Progress 1997-98: World Health Organization: Geneva (1999).
2. Gutteridge W. E., Bri. Mad. Bull., 41, 162-168 (1985).
3. Umezawa E. S., Stolf A. M. S., Corbett C. E. P., Shikanai-Yasuda M. A., Lancet, 357, 797-799 (2001).
4. Castro C., Jiménez-Estrada M., González de la Parra M., Planta Medica, 58, 281-282 (1992).
5. Cáceres A., López B., González S., Berger I., Tada I., Maki J., J. Ethnopharm., 62, 195-202 (1998).
6. Diaz J. I., "Usos de las Plantas Medicinales de Mexico." IMEPLAM, Mexico City, 1976, pp. 145-150.
7. Enriquez R. G., Chavez M. A., Reynolds W. F., J. Nat. Prod., 47, 896-899 (1984).
8. Baum S. G., Wittner M., Jeffrey P. N., Nadler J. P., Horwitz S. B., Dennis J. E., Schiff P. B., Tanowitz H. B., Proc. Natl. Acad. Sci. U.S.A., 78, 4571-4575 (1981).
9. Bowden B. F., Ritchie E., Taylor W. C., Aust. J. Chem., 25, 2659-2669 (1972).
10. Read R. W., Taylor W. C., Aust. J. Chem., 32, 2317-2321 (1979).
11. McCredie R. S., Ritchie E., Taylor W. C., Aust. J. Chem., 22, 1011-1032 (1969).
12. Takaoka D., Watanabe K., Hiroi M., Bull. Chem. Soc. Jpn., 49, 3564-3566 (1976).
13. Murphy S. T., Ritchie E., Taylor W. C., Aust. J. Chem., 28, 81-90 (1975).
14. Hada S., Hattori M., Tezuka Y., Kikuchi T. Namba T., Phytochemistry, 27, 563-568 (1988).
15. Sepúlveda-Boza S., Cassels B. K., Planta Medica, 62, 98-105 (1996).
16. Schlemper B. R., Jr., Chiari E., Brener Z., J. Protozool., 24, 544-547 (1977).
17. Hocquemiller R., Cortes D., Arango G. J., Myint S. H., Cavé A., Angelo A., Muñoz V., Fournet et A., J. Nat. Prod., 54, 445-452 (1991).
18. Argueta-Villamar A., Cano-Asseleih L. M., Rodarte M. E. (eds.), "Atlas de las Plantas de la Medicina Tradicional Mexicana," Vols. I, II & III, Instituto Nacional Indigenista, Mexico City, 1994.
19. Cáceres A., Maki J., López B., "Enfennedades Tropicales en Guatemala 93," Guatemala, JICA, 1993, pp. 140-143.
20. Montamat E. E., Burgos C., Gerez de Burgos N. M., Rovai L. E., Blanco A., Segura E. L., Science, 218, 288-289 (1982). They described that growth of T. cruzi in culture was inhibited almost completely at a 25 μM concentration of gossypol. No description on the strain was made in this report.
21. Cavin J. C., Krassner S. M., Rodriguez E., J. Ethnopharm., 19, 89-95 (1987). They mentioned that harmine and berberine hydrochloride were effective in reducing growth more than 90% and 74%, respectively, at 50 μg/ml (96 h) using epimastigotes of T. cruzi (Costa Rica strain).
22. Bastos J. K., Albuquerque S., Silva M. L. A., Planta Medica, 65, 541-544 (1999). In vitro trypanocidal activity of (-)-methylpulviatolide against trypomastigotes is described as below: Bolivia strain (25 μg/ml, 88%; 50 μg/ml, 100%), Y strain (25 μg/ml, 99%; 50 μg/ml, 100%), Gentian violet as a positive control.