Substrate specificity of HMRZ-86 for β-lactamases, including extended-spectrum β-lactamases (ESBLs)

Journal of Infection and Chemotherapy

Volumn 13, Issue 6, 2007, Pages 390-395

  Hanaki, Hideaki ^a   Koide, Yuuji ^b   Yamazaki, Hiroaki ^b   Kubo, Ryoichi ^c   Nakano, Tomota ^d   Atsuda, Koichiro ^e   Sunakawa, Keisuke ^e  

^a KITASATO INSTITUTE   (Japan)

^b ZENYAKU KOGYO CO LTD   (Japan)

^c KANTO CHEMICAL CO INC   (Japan)

^d Isehara Research Laboratory   (Japan)

^e KITASATO UNIVERSITY   (Japan)

Author keywords

Enzymology; Extended spectrum lactamases (ESBLs); HMRZ 86; Metallo lactamase (MBL); Lactamase

Indexed keywords

BETA LACTAMASE; BETA LACTAMASE AMPC; BUFFER; CHROMOGENIC SUBSTRATE; EXTENDED SPECTRUM BETA LACTAMASE; HMRZ 86; METALLO BETA LACTAMASE; NITROCEFIN; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); ENZYME ASSAY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CEPHALOSPORINS; GRAM-NEGATIVE BACTERIA; HUMANS; KINETICS; SUBSTRATE SPECIFICITY;

EID: 37349030908     PISSN: 1341321X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10156-007-0563-2     Document Type: Article

References (19)

1. Knothe H, Shah P, Krcmery V, Antal M, Mitsuhashi S. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection 1983;11:315-7.
2. Ishii Y, Ohno A, Taguchi H, Imajo S. Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A β-lactamase isolated from Escherichia coli. Antimicrob Agents Chemother 1995;39:2269-75.
3. Okamoto R, Yuko S, Nakano R. J Med Technol 2001;45:833-9.
4. Sabath LD, Abdaham EP. Zinc as a cofactor for a cephalosporinase from Bacillus cereus. Biochem J 1966;98:11c-3c.
5. Saino Y, Kobayashi F, Inoue M, Mitsuhashi S. Purification and properties of an inducible penicillin β-lactamase isolated from Pseudomonas maltophilia. Antimicrob Agents Chemother 1982;22:564-70.
6. Philippon A, Arlet G, Jacoby G, Plasmid-Determined AmpC-Type β-lactamases. Antimicrob Agents Chemother 2002;46:1-11.
7. Bladford PA. Extended-spectrum beta-lactamases in the twenty-first century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev 2001;14:933-51.
8. Hanaki H, Kubo R, Nakano T, Kurihara M, Sunagawa K. Characterization of HMRZ-86:a novel chromogenic cephalosporin for the detection of extended-spectrum β-lactamases. J Antimicrob Chemother 2004;53:888-9.
9. Hanaki H, Yamazaki H, Harada H, Kobayashi T, Atsuda T, Sunagawa K. The synthesis of 7-substituted-3-dinitrostyl cephalosporins and their ability for detecting extended-spectrum β-lactamases (ESBL). J Antibiot (Tokyo) 2005;58:69-73.
10. George J, Luis S. Mechanisms of disease. The new β-lactamases. New Engl J Med 2005;27:380-91.
11. Colodner R, Reznik B, Gal V, Yamazaki H, Hanaki H, Kubo R. Evaluation of novel kit for the rapid detection of extended-spectrum beta-lactamases. Eur J Clin Microbiol Infect Dis 2005;25:49-51.
12. Jain S, Andrews J, Fraise A, Brenwald N. Rapid detection of extended-spectrum β-lactamase-producing Gram-negative bacilli in blood cultures. J Antimicrob Chemother 2007;60:652-4.
13. Yague A, Rodriguez J, Sandvang D, Evaluation of a fast method for the detection of extended-spectrum β lactamase using a chromogenic cephalosporin. Rev Esp Quimioter 2006;19:185-6.
14. Knox R. Extended-spectrum and inhibitor-resistant TEM-type β-lactamases: mutations, specificity and three dimensional structure. Antimicrob Agents Chemother 1995;39:2593-601.
15. Ibuka A, Taniguchi A, Ishiguro M, Yamaguchi K, Frere J, et al. Crystal stracture of the E166A mutant of extended-spectrum β-lactamases Toho-1 at 1.8Å resolution. J Mol Biol 1999;285:2079-87.
16. Medeiros AA. Evolution and dissemination of β-lactamases accelerated by generations of β-lactam antibiotics. Clin Infect Dis 1997;24(Suppl. 1):S19-45.
17. Sander WE. Enterobacter spp pathogens poised to flourish at the turn of the century. Clin Microbiol Rev 1997;10:220-41.
18. Galleni, M, Brassur JL, Rossolini GM. Standard numbering scheme for class B β-lactamases. Antimicrob Agents Chemother 2001;45:660-3.
19. Kubo R, Nakano T. Resistant bacteria against β-lactam antibiotics. The Chemical Times 2004;1:19-21.