The synthesis of 7-substituted-3-dinitrostyryl cephalosporins and their ability for detecting extended spectrum β-lactamases (ESBLs)

Journal of Antibiotics

Volumn 58, Issue 1, 2005, Pages 69-73

  Hanaki, Hideaki ^a   Yamazaki, Hiroaki ^b   Harada, Hidenori ^b   Kubo, Ryoichi ^c   Kobayashi, Takayoshi ^c   Atsuda, Koichiro ^d   Sunakawa, Keisuke ^d  

^a KITASATO INSTITUTE   (Japan)

^b ZENYAKU KOGYO CO LTD   (Japan)

^c KANTO CHEMICAL CO INC   (Japan)

^d KITASATO UNIVERSITY   (Japan)

Author keywords

Cephalosporin; Chromogenic; ESBL; HMRZ 86; Lactamase

Indexed keywords

3 (2,4 DINITROSTYRYL)CEPHALOSPORIN DERIVATIVE; 7 [2 (AMINOTHIAZOL 4 YL) 2 (1 CARBOXY 1 METHYLETHOXYIMINO)ACETAMIDO] 3 (2,4 DINITROSTYRYL) 3 CEPHEM 4 CARBOXYLIC ACID TRIFLUOROACETATE; BETA LACTAMASE; CEPHALOSPORIN DERIVATIVE; CHROMOGENIC SUBSTRATE; HMRZ 86; NITROCEFIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; COLOR; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; IN VITRO STUDY; INHIBITION KINETICS; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 14544297528     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2005.9     Document Type: Article

References (5)

1. Jacoby GA. Epidemiology of extended-spectrum β-lactamases. Clin Infect Dis 27: 81-83 (1993)
2. O'callaghan CH, Morris A, Kirby SM, et al. Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother 4: 283-288 (1972)
3. National Commitee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. NCCLS document M7-A4. National Committee for Clinical Laboratory Standards, Wayne, Pa.
4. Hanaki H, Kubo R, Murata A, Yamazaki H, Sunakawa K. Novel chimical compound for detecting ESBLs. 103rd American Society for Microbiology General Meeting; Washington DC. Presentation No. A-056, 2003
5. Hanaki H, Kubo R, et al. Characterization of HMRZ-86: a novel chromogenic cephalosporin for detection of extended-spectrum β-lactamases. J Antimicrob Chemother 53: 888-889 (2004)