Biocompatibility of intraocular lens materials

Current Opinion in Ophthalmology

Volumn 19, Issue 1, 2008, Pages 41-49

  Werner, Liliana ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Berlin Eye Research Institute   (Germany)

Author keywords

Biocompatibility; Hydrophilic acrylic; Hydrophobic acrylic; Intraocular lens; Silicone

Indexed keywords

BIOMATERIAL; POLY(DIMETHYL SILOXANE); POLYACRYLIC ACID; UNCLASSIFIED DRUG;

BIOCOMPATIBILITY; CATARACT; CELL PROLIFERATION; ENVIRONMENT; EPITHELIUM CELL; EYE; EYE INFLAMMATION; HUMAN; LENS EPITHELIUM; LENS IMPLANT; LENS IMPLANTATION; LIFE; NONHUMAN; OPTICS; PEDIATRICS; PRIORITY JOURNAL; REVIEW; UVEA;

ACRYLIC RESINS; BIOCOMPATIBLE MATERIALS; CELL PROLIFERATION; FOREIGN-BODY REACTION; HUMANS; LENS CAPSULE, CRYSTALLINE; LENSES, INTRAOCULAR; MATERIALS TESTING; RISK FACTORS; SILICONE ELASTOMERS;

EID: 37349022393     PISSN: 10408738     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICU.0b013e3282f20132     Document Type: Review

References (28)

1. Christ FR, Fencil DA, Van Gent S, Knight PM. Evaluation of the chemical, optical, and mechanical properties of elastomeric intraocular lens materials and their clinical significance. J Cataract Refract Surg 1989; 15:176-184.
2. Christ FR, Buchen SY, Deacon J, et al. Biomaterials used for intraocular lenses. In: Wise DL, Trantolo DJ, Altobelli DE, et al., editors. Encyclopedic handbook of biomaterials and bioengineering. Part B: applications, volume 2. New York: Marcel Dekker; 1995. pp. 1261-1313.
3. Werner L, Apple DJ, Schmidbauer J. Ideal IOL (PMMA and foldable) for year 2002. In: Buratto L, Werner L, Zanini M, Apple DJ, editors. Phacoemulsification principles and techniques. Thorofare: Slack; 2003. pp. 435-452.
4. Allmer K, Hilborn J, Larsson PH, et al. Surface modification of polymers. V. Biomaterial applications. J Appl Polym Sci Polym Chem 1990; 28:173-183.
5. Werner L, Legeais JM, Durand J, et al. Endothelial damage caused by uncoated and fluorocarbon-coated polymethylmethacrylate intraocular lenses. J Cataract Refract Surg 1997; 23:1013-1019.
6. Legeais JM, Werner LP, Legeay G, et al. In vivo study of a fluorocarbon polymer-coated intraocular lens in a rabbit model. J Cataract Refract Surg 1998; 24:371-379.
7. Werner L, Legeais JM, Nagel MD, Renard G. Evaluation of Teflon coated intraocular lenses in an organ culture method. J Biomed Mater Res 1999; 46:347-354.
8. Werner L, Legeais JM, Nagel MD, Renard G. Neutral red assay of the cytotoxicity of fluorocarbon-coated polymethylmethacrylate intraocular lenses in vitro. J Biomed Mater Res 1999; 48:814-819.
9. Wejde G, Kugelberg M, Zetterstrom C. Posterior capsule opacification: comparison of 3 intraocular lenses of different materials and design. J Cataract Refract Surg 2003; 29:1556-1559.
10. Zetterström C, Lundvall A, Kugelberg M. Cataracts in children. J Cataract Refract Surg 2005; 31:824-840.
11. Koch DD, Samuelson SW, Dimonie V. Surface analysis of surface-passivated intraocular lenses. J Cataract Refract Surg 1991; 17:131-138.
12. Eloy R, Parrat D, Duc TM, et al. In vitro evaluation of inflammatory cell response after CF4 plasma surface modification of poly(methyl methacrylate) intraocular lenses. J Cataract Refract Surg 1993; 19:364-370.
13. Mencucci R, Mercatelli L, Fusi F, et al. AcrySof Natural intraocular lens optical characteristics during and after different doses of ultraviolet-visible light illumination. J Cataract Refract Surg 2006; 32:1961-1965. This interesting experimental study describes the optical transmission properties of the AcrySof Natural after a UV/visible light dose equivalent to 100 years of light aging. It shows that this lens has long-term stable optical characteristics.
14. Pandita D, Raj SM, Vasavada VA, et al. Contrast sensitivity and glare disability after implantation of AcrySof IQ Natural aspherical intraocular lens: prospective randomized masked clinical trial. J Cataract Refract Surg 2007; 33:603-610. This triple-masked trial, performed on 120 consecutive patients, showed that eyes with the AcrySof IQ SN60WF IOL had significantly higher contrast sensitivity than eyes with an AcrySof SA60AT or AcrySof Natural SN60AT IOL at all spatial frequencies during mesopic testing (with and without glare) with 4.0 and 6.0mm artificial pupils.
15. Muftuoglu O, Karel F, Duman R. Effect of a yellow intraocular lens on scotopic vision, glare disability, and blue color perception. J Cataract Refract Surg 2007; 33:658-666. Clinical study comparing the photopic and scotopic contrast sensitivity (with and without glare), and blue color perception between eyes with an AcrySof Natural and eyes with a conventional AcrySof SA60AT IOL.
16. Beauchamp CL, Stager DR Jr, Weakley DR Jr, et al. Surgical findings with the tinted AcrySof intraocular lens in children. J AAPOS 2007; 11:166-169. Retrospective study showing that yellow IOLs had a higher incidence of transient inflammation than the standard lens, but the rates of nontransient sequelae (posterior synechiae, iris synechiae, membranes formation, capsule or IOL opacification) were similar.
17. Mainster MA. Intraocular lenses should block UV radiation and violet but not blue light. Arch Ophthalmol 2005; 123:550-555.
18. Mainster MA. Violet and blue light blocking intraocular lenses: photoprotection versus photoreception. Br J Ophthalmol 2006; 90:784-792. In this interesting study, transmittance spectra values are used to theoretically predict the effect of spectral filters on retinal photoprotection, scotopic sensitivity and circadian photoentrainment.
19. Werner L, Mamalis N, Romaniv N, et al. New photochromic foldable intraocular lens: preliminary study of feasibility and biocompatibility. J Cataract Refract Surg 2006; 32:1214-1221. This 6-month rabbit study evaluates the biocompatibility of a new photochromic IOL biomaterial. The photochromic property would put an end to the controversy regarding decreased scotopic vision with yellow IOLs.
20. Schwartz DM, Sandstedt CA, Chang SH, et al. Light-adjustable lens: development of in vitro nomograms. Trans Am Ophthalmol Soc 2004; 102:67-72; discussion 72-74.
21. Werner L, Yeh O, Haymore J, et al. corneal endothelial safety with the irradiation system for light-adjustable intraocular lenses. J Cataract Refract Surg 2007; 33:873-878. Experimental cat study designed to assess the safety to the corneal endothelium of the irradiation delivered through a system developed for noninvasive postoperative power adjustments of the light adjustable lens.
22. Bozukova D, Pagnoulle C, Pauw-Gillet MC, et al. Improved performances of intraocular lenses by poly(ethylene glycol) chemical coatings. Biomacromolecules 2007; Epub ahead of print. Experimental study describing a new chemical coating on the surface of hydrogel lenses, which decreased protein adsorption and cell adhesion, and, therefore, with potential for PCO prevention.
23. Yao K, Huang XD, Huang XJ, Xu ZK. Improvement of the surface biocompatibility of silicone intraocular lens by the plasma-induced tethering of phospholipid moieties. J Biomed Mater Res A 2006; 78:684-692. This new surface treatment of silicone lenses renders the material more hydrophilic and suppresses cell adhesion, also with potential for PCO prevention.
24. Okajima Y, Saika S, Sawa M. Effect of surface coating an acrylic intraocular lens with poly(2-methacryloyloxyethyl phosphorylcholine) polymer on lens epithelial cell line behavior. J Cataract Refract Surg 2006; 32:666-671. This new surface treatment of hydrophobic acrylic lenses suppresses cell adhesion and proliferation, also with potential for PCO prevention.
25. Matsushima H, Iwamoto H, Mukai K, Obara Y. Active oxygen processing for acrylic intraocular lenses to prevent posterior capsule opacification. J Cataract Refract Surg 2006; 32:1035-1040. Rabbit study showing statistically significant PCO inhibition by the treated IOLs, in comparison with the untreated lenses.
26. Obstbaum SA. The Binkhorst Medal Lecture. Biologic relationship between poly(methyl methacrylate) intraocular lenses and uveal tissue. J Cataract Refract Surg 1992; 219-231.
27. Hollick EJ, Spalton DJ, Ursell PG, Pande MV. Biocompatibility of poly(methyl methacrylate), silicone, and AcrySof intraocular lenses: randomized comparison of the cellular reaction on the anterior lens surface. J Cataract Refract Surg 1998; 24:361-366.
28. Amon M. Biocompatibility of intraocular lenses. J Cataract Refract Surg 2001; 27:178-179.