Synthetic biology: Promises and challenges

Molecular Systems Biology

Volumn 3, Issue , 2007, Pages 158-

  Serrano, Luis ^a  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS SUBTILIS; BIOENGINEERING; BIOTECHNOLOGY; DEVELOPMENTAL BIOLOGY; EDITORIAL; ESCHERICHIA COLI; GENE; GENETIC ENGINEERING; PRIORITY JOURNAL; PROKARYOTE; QUALITY OF LIFE; SYNTHETIC BIOLOGY;

BIOTECHNOLOGY; BIOTERRORISM; CROPS, AGRICULTURAL; FORECASTING; GENETIC ENGINEERING; INDUSTRIAL MICROBIOLOGY; LIFE; MACROMOLECULAR SUBSTANCES; MOLECULAR BIOLOGY; ORGANISMS, GENETICALLY MODIFIED; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37349009767     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb4100202     Document Type: Editorial

References (25)

1. Anderson JC, Clarke EJ, Arkin AP, Voigt CA (2006) Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol 355: 619-627
2. Anderson JC, Voigt CA, Arkin AP (2007) Environmental signal integration by a modular AND gate. Mol Syst Biol 3: 133
3. Andrianantoandro E, Basu S, Karig DK, Weiss R (2006) Synthetic biology: new engineering rules for an emerging discipline. Mol Syst Biol 2: 0028
4. Becskei A, Seraphin B, Serrano L (2001) Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J 20: 2528-2535
5. Becskei A, Serrano L (2000) Engineering stability in gene networks by autoregulation. Nature 405: 590-593
6. Benner SA, Sismour AM (2005) Synthetic biology. Nat Rev Genet 6: 533-543
7. Bhutkar A (2005) Synthetic biology: navigating the challenges ahead. J Biolaw Bus 8: 19-29
8. Bügl H, Danner JP, Molinari RJ, Mulligan JT, Park HO, Reichert B, Roth DA, Wagner R, Budowle B, Scripp RM, Smith JA, Steele SJ, Church G, Endy D (2007) DNA synthesis and biological security. Nat Biotechnol 25: 627-629
9. Chan LY, Kosuri S, Endy D (2005) Refactoring bacteriophage T7. Mol Syst Biol 1: 0018
10. Check E (2006) Synthetic biologists try to calm fears. Nature 441: 388-389
11. Church GM (2005) From systems biology to synthetic biology. Mol Syst Biol 1: 0032
12. Di Ventura B, Lemerle C, Michalodimitrakis K, Serrano L (2006) From in vivo to in silico biology and back. Nature 443: 527-533
13. Elowitz MB, Leibler S (2000) A synthetic oscillatory network of transcriptional regulators. Nature 403: 335-338
14. Endy D (2005) Foundations for engineering biology. Nature 438: 449-453
15. Gardner TS, Cantor CR, Collins JJ (2000) Construction of a genetic toggle switch in Escherichia coli. Nature 403: 339-342
16. Gardner TS, Collins JJ (2000) Neutralizing noise in gene networks. Nature 405: 520-521
17. Heinemann M, Panke S (2006) Synthetic biology - putting engineering into biology. Bioinformatics 22: 2790-2799
18. Isalan M, Lemerle C, Serrano L (2005) Engineering gene networks to emulate Drosophila embryonic pattern formation. PLoS Biol 3: e64
19. Lartigue C, Glass JI, Alperovich N, Pieper R, Parmar PP, Hutchison III CA, Smith HO, Venter JC (2007) Genome transplantation in bacteria: changing one species to another. Science 317: 632-638
20. Lindahl AL, Olsson ME, Mercke P, Tollbom O, Schelin J, Brodelius M, Brodelius PE (2006) Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. Biotechnol Lett 28: 571-580
21. Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD (2003) Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 21: 796-802
22. Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440: 940-943
23. Tucker JB, Zilinskas RA (2006) The promise and perils of synthetic biology. New Atlantis 12: 25-45
24. Tumpey TM, Basler CF, Aguilar PV, Zeng H, Solorzano A, Swayne DE, Cox NJ, Katz JM, Taubenberger JK, Palese P, Garcia-Sastre A (2005) Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310: 77-80
25. Win MN, Smolke CD (2007) From the cover: a modular and extensible RNA-based gene-regulatory platform for engineering cellular function. Proc Natl Acad Sci USA 104: 14283-14288