Analysis of Oct-4 expression and ploidy in individual human blastomeres

Molecular Human Reproduction

Volumn 7, Issue 2, 2001, Pages 155-161

  Hansis, Christoph ^a,b   Tang, Yaxu ^a   Grifo, James A ^a   Krey, Lewis C ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Human blastomeres; Oct 3; Oct 4; Preimplantation genetic diagnosis; Totipotency

Indexed keywords

ANEUPLOIDY; ARTICLE; BLASTOMERE; CELL NUCLEUS; CONTROLLED STUDY; DIPLOIDY; EMBRYO; EMBRYO CELL; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENETIC ANALYSIS; GERM CELL; GERMINAL VESICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; INNER CELL MASS; MARKER GENE; OOCYTE CLEAVAGE; PLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ILEX COOKII; MURINAE;

EID: 0035129238     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/7.2.155     Document Type: Article

References (29)

1. Expression of transcription regulating genes in human preimplantation embryos
2. Extinction of Oct3/4 gene expression in embryonal carcinomaXfibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure and transcriptional activity of the Oct3/4 upstream region
3. Human gene expression first occurs between the four- and eight-cell stages of preimplantation development
4. The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain
5. Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients
6. Oocyte polarity and cell determination in early mammalian embryos
7. Mosaicism in the inner cell mass of human blastocysts
8. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts
9. Apoptosis in the human embryo
10. Mosaicism of autosomes and sex chromosomes in morphologically normal, monospermic preimplantation human embryos
11. Expression of Homeobox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies
12. Retinoic acid-mediated down-regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo
13. Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities
14. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
15. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
16. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
17. The molecular biology of Oct-4 in the early mouse embryo
18. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation
19. Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2
20. The expression of genes in human preimplantation embryos
21. In line with our ancestors: Oct-4 and the mammalian germ
22. Retinoic acid represses Oct-3/4 gene expression through several retinoic-acid responsive elements located in the promoter-enhancer region
23. Novel method for studying mRNA phenotypes in single or small numbers of cells
24. Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
25. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
26. Oct-4: A germline-specific transcription factor mapping to the mouse t-complex
27. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues
28. Activation of nucleolar and extra-nucleolar RNA synthesis and changes in ribosomal content of human embryos developing in vitro
29. Isolation of cDNA libraries from individual human preimplantation embryos