Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines

Journal of Medicinal Chemistry

Volumn 50, Issue 26, 2007, Pages 6485-6492

  Migliore, Marco D ^a   Zonta, Nicola ^a   McGuigan, Christopher ^a   Henson, Geoffrey ^b   Andrei, Graciela ^c   Snoeck, Robert ^c   Balzarini, Jan ^c  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b Inhibitex   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

6 PENTYLPHENYLFURO[2,3 D]PYRIMIDINE 2' DEOXYRIBOSE; CARBOCYCLIC NUCLEOSIDE; DEOXYURIDINE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL LINE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MONOLAYER CULTURE; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY; VARICELLA ZOSTER VIRUS;

ANTIVIRAL AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; CYCLOPENTANES; FURANS; HERPESVIRUS 3, HUMAN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIMIDINE NUCLEOSIDES; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37349002731     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070357e     Document Type: Article

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