A tandem aza-claisen rearrangement and ring closing metathesis reaction for the synthesis of cyclic allylic trichloroacetamides

Organic Letters

Volumn 9, Issue 25, 2007, Pages 5239-5242

  Swift, Michael D ^a   Sutherland, Andrew ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 37249079622     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol702299c     Document Type: Article

References (43)

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37. As highlighted in Scheme 3, use of Grubbs second-generation and Hoveyda-Grubbs second-generation catalysts gave cyclic allylic trichloroacetamide 6 in slightly higher yield than with the Grubbs first-generation catalyst. Nevertheless, in developing the subsequent reactions, we have used mainly Grubbs first-generation catalyst due to its relatively low cost and availability compared to the other catalysts.
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43. The enantiomeric excess of compounds 14 and 15 was determined by chiral HPLC See Supporting Information for full details.