Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection

Journal of Neurochemistry

Volumn 104, Issue 1, 2008, Pages 100-112

  Rubio, Nazario ^a   Gonzalez Tirante, Maria ^a   Arevalo, Maria Angeles ^a   Aranguez, Isabel ^b  

^a INSTITUTO CAJAL   (Spain)

^b UNIVERSITY OF MADRID   (Spain)

Author keywords

Astrocytes; DNA arrays; GTPases; GTPbinding proteins; Membranes; Theiler's virus

Indexed keywords

CHEMOKINE; GAMMA INTERFERON; GLUTATHIONE TRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 6; MUNC18 PROTEIN; PROTEIN G; PROTEIN INTERACTING WITH PROTEIN KINASE C; PROTEIN SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BINDING AFFINITY; CELL LYSATE; CONTROLLED STUDY; CROSS LINKING; DNA HYBRIDIZATION; ENCEPHALOMYELITIS; GENE ACTIVATION; MICROARRAY ANALYSIS; MICROCHIP ANALYSIS; MOLECULAR GENETICS; MURINE ENCEPHALOMYELITIS VIRUS; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL MEMBRANE; CELLS, CULTURED; CEREBRAL CORTEX; CHEMOKINES; CRICETINAE; GENE EXPRESSION REGULATION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; MICE; MICE, INBRED STRAINS; THEILOVIRUS;

MAMMALIA; MURINAE; MUS; THEILER'S ENCEPHALOMYELITIS VIRUS;

EID: 37249069513     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05020.x     Document Type: Article

References (43)

1. Adams D. O. Hamilton T. A. (1994) Molecular basis of macrophage activation: Diversity and its origins, in The Natural Immune System: The Macrophage (Lewis C. E. McGee J. O., eds), pp. 77 114. IRL Press, New York.
2. Apicelli A. J., Uhlmann E. J., Baldwin R. L., Ding H., Nagy A., Guha A. Gutmann D. H. (2003) Role of the Rap1 GTPase in astrocyte growth regulation. Glia 42, 225 234.
3. Barbacid M. (1987) Ras genes. Annu. Rev. Biochem. 56, 779 827.
4. Bogusky M. S. McCormick F. (1993) Proteins regulating Ras and its relatives. Nature 366, 643 653.
5. Bouschet T., Perez V., Fernandez C., Bockaert J., Eychene A. Journot L. (2003) Stimulation of the ERK pathway by GTP-loaded rap1 requires the concomitant activation of ras, protein kinase C, and protein kinase A in neuronal cells. J. Biol. Chem. 278, 4778 4785.
6. Cantley L. C., Auger K. R., Carpenter C., Duckworth B., Graziani A., Kapeller R. Soltoff S. (1991) Oncogenes and signal transduction. Cell 64, 281 302.
7. Cassel D. Selinger Z. (1976) Catecholomine-stimulated GTPase in turkey erythrocyte membranes. Biochem. Biophys. Acta 452, 538 551.
8. Clatch R. J., Lipton H. L. Miller S. D. (1986) Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J. Immunol. 136, 920 927.
9. Dal Canto M. C. Lipton M. C. (1976) Primary demyelination in Theiler's virus infection. Lab. Invest. 33, 626 637.
10. Etienne-Manneville S. Hall A. (2002) Rho GTPase in cell biology. Nature 420, 629 635.
11. x/z is regulated by μ but not δ opioid receptors in the stimulation of the low Km GTPase activity in mouse periaqueductal grey matter. Eur. J. Neurosciences 9, 1194 1200.
12. oα subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice. Neuropharmacology 38, 1861 1873.
13. Gengyo-Ando K., Kitayama H., Mukaida M. Ikawa Y. (1996) A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. J. Neurosci. 16, 6695 6702.
14. Gilman A. G. (1987) G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56, 615 649.
15. Grand R. J. Owen D. (1991) The biochemistry of Ras p21. Biochem. J. 279, 609 631.
16. Hall A. (1990) The cellular functions of small GTP-binding proteins. Science 249, 636 640.
17. Haydon P. G. Carmignoto G. (2006) Astrocyte control of synaptic transmission and neurovascular coupling. Physiol. Rev. 86, 1009 1031.
18. Hille B. (1992) G-protein-coupled mechanisms and nervous signalling. Neuron 9, 187 194.
19. Höltje M., Hoffmann A., Hofmann F., Mucke C., Groβe G., Van Rooijen N., Kettenmann H., Just I. Ahnert-Hilger G. (2005) Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing. J. Neurochemistry 95, 1237 1248.
20. Jelachich M. L., Bandyopahyay P., Blum K. Lipton H. L. (1995) Theiler′s virus growth in murine macrophage cell lines depends on the state of differentiation. Virology 209, 437 444.
21. Kaziro Y., Itoh H., Kozasa T., Nakafuko M. Satoh T. (1991) Structure and function of signal-transducing GTP-binding proteins. Ann. Rev. Biochem. 60, 349 400.
22. Kudo H., Senju S., Mitsuya H. Nishimura Y. (2000) Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase. Biochem. Biophys. Res. Commun. 272, 456 465.
23. Laggerbauer B., Lauber J. Luhrmann R. (1996) Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs. Nucleic Acids Res. 24, 868 875.
24. Lipton H. L. (1975) Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination. Infect. Immun. 11, 1147 1155.
25. Lipton H. L. Dal Canto M. L. (1976) Theiler's virus induced demyelination: prevention by immunosuppression. Science 192, 62 64.
26. Maguire J., Santoro X., Jensen P., Siebenlist U., Yewdell J. Kelly K. (1994) Gem: an induced, immediate early protein belonging to the Ras family. Science 265, 241 244.
27. Nobes C. D. Hall A. (1999) Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144, 1235 1244.
28. O'Neill L. A., Birg J., Gearing T. A. Saklatvala J. H. (1990) Interleukin-1 signal transduction. Increased GTPbinding and hydrolysis in membranes of a murine thymoma line (EL4). J. Biol. Chem. 254, 3146 3152.
29. Palma J. P., Kwon D., Clipstone X. Kim B. S. (2003) Infection with Theiler′s murine encephalomyelitis virus direct induces proinflammatory cytokines in primary astrocytes via NF-κB activation: potential role for the initiation of demyelinating disease. J. Virol. 77, 6322 6331.
30. Peña Rossi C., Delcroix M., Huitinga I., McAllister A., Van Rooijen N., Claassen E. Brahic M. (1997) Role of macrophages during Theiler's virus infection. J. Virol. 71, 3336 3340.
31. Porter F. W., Bochkov Y. A., Albee A. J., Wiese C. Palmenberg A. C. (2006) A picornavirus protein interacts with Ran-GTPase and disrupts nycleocytoplasmic transport. PNAS 103, 12417 12422.
32. Robitaille R. (1998) Modulation of synaptic efficacy and synaptic depression by glial cell at the frog neuromuscular junction. Neuron 21, 847 855.
33. Rubio N. (2001) Interferon-γ protects astrocytes from apoptosis and increases the formation of p21ras-GTP complex through ras oncogene family overexpression. Glia 33, 151 159.
34. Rubio N. Sanz-Rodriguez F. (2007) Induction of the CXCL1 (KC) chemokine in mouse astrocytes by infection with the murine encephalomyelitis virus of Theiler. Virology 358, 98 108.
35. Rubio N., Martin-Clemente B. Lipton H. L. (2003) High- neurovirulence GDVII virus induces apoptosis in murine astrocytes through tumor necrosis factor (TNF)-receptor and TNF-related apoptosis induced ligand. Virology 311, 366 375.
36. Rubio N., Sanz-Rodriguez F. Lipton H. L. (2006) Theiler′s virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains. Cell. Immunol. 239, 31 40.
37. i2α subunits of GTP-binding proteins are mitogens following their internalization by astrocytes in culture. Mol. Brain. Research 110, 15 26.
38. So E. Y., Kang M. H. Kim B. S. (2006) Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the Toll-like receptor 3. Glia 53, 858 867.
39. Sorace J. M., Johnson R. J., Howard D. L. Drysdale B. E. (1995) Identification of an endotoxin and IFN-inducible cDNA: possible identification of novel protein family. J. Leukoc. Biol. 58, 477 484.
40. Staudinger J., Zhou J., Burgess R., Elledge S. J. Olson E. N. (1995) PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J. Cell Biol. 128, 263 271.
41. Takai Y., Sasaki T., Tanaka K. Nakanishi H. (1995) Rho as a regulator of the cytoskeleton. Trends Biochem. Sci. 20, 227 231.
42. Theiler M. (1937) Spontaneous encephalomyelitis of mice, a new virus disease. J. Exp. Med. 65, 705 719.
43. Zheng L., Calenoff M. A. Dal Canto M. C. (2001) Astrocytes, not microglia, are the main cells responsible for viral persistence in Theiler′s murine encephalomyelitis virus infection leading to demyelination. J. Neuroimmunol. 118, 256 267.