Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey

Chemical Research in Toxicology

Volumn 20, Issue 11, 2007, Pages 1709-1717

  Daniels, J Scott ^a,b   Espina, Robert ^a,b   Cao, Kevin ^a   Yuan, Haodan ^a   Lin, Jianrong ^a   Diamond, Sharon ^a,c   Johnson, Barry ^a   Rodgers, James ^a,c   Prakash, Shimoga ^a,d   Unger, Steve ^a   Christ, David ^a,e   Miwa, Gerald ^a,d   Gan, Liang Shang ^a,f   Mutlib, Abdul ^a,b  

^a BRISTOL MYERS SQUIBB   (United States)

^b PFIZER INC   (United States)

^c Experimental Station   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e SNC Partners LLC   (United States)

^f BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 DIHYDROBENZO[B][1,8]NAPHTHYRIDIN N OXIDE; BMSA 78277; DRUG METABOLITE; NAPHTHYRIDINE DERIVATIVE; NAPHTHYRIDINE N OXIDE; OXYGEN 18; RNA DIRECTED DNA POLYMERASE INHIBITOR; SULFOTRANSFERASE; UNCLASSIFIED DRUG; WATER;

AMNION BAND; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG ACTIVITY; DRUG LABELING; DRUG METABOLISM; DRUG SYNTHESIS; DRUG TRANSFORMATION; LIVER CELL; MASS SPECTROMETRY; MICROSOME; MONKEY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; BIOTRANSFORMATION; CYCLIC N-OXIDES; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; HEPATOCYTES; HIV REVERSE TRANSCRIPTASE; MACACA FASCICULARIS; MALE; MICROSOMES, LIVER; NAPHTHYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE INHIBITORS; SPECIES SPECIFICITY; SULFOTRANSFERASES;

HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA FASCICULARIS;

EID: 37249048136     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700170q     Document Type: Article

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