Inhibition of proliferation and differentiation by RU 486 in human endometrial stromal and epithelial cells in vitro

Experimental and Clinical Endocrinology and Diabetes

Volumn 108, Issue 4, 2000, Pages 275-281

  Prange Kiel, J ^a   Rune, G M ^a   Wallwiener, D ^b   Kiesel, L ^b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Differentiation; Human endometrial cell culture; Proliferation; RU 486

Indexed keywords

ANTIGESTAGEN; CRYSTAL VIOLET; ESTRADIOL; GESTAGEN; MIFEPRISTONE; PROGESTERONE; PROLACTIN;

ARTICLE; BENIGN TUMOR; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOMETRIUM CELL; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYSTERECTOMY; IN VITRO STUDY; MENSTRUAL CYCLE; PRIORITY JOURNAL; STROMA CELL;

CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; DRUG COMBINATIONS; ENDOMETRIUM; EPITHELIAL CELLS; FEMALE; HUMANS; MIFEPRISTONE; PROGESTERONE; STROMAL CELLS;

EID: 0033940914     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2000-7755     Document Type: Article

References (37)

1. Berthois Y, Salat-Baroux J, Cornet D, De Brux J, Kopp F, Martin PM: A multiparametric analysis of endometrial estrogen and progesterone receptors after the postovulatory administration of mifepristone. Fertil Steril 55: 547-554, 1991
2. Bhargava-Periwal S, Farooq A, Bhargava VL, Bhatla N, Vij U, Murugesan K: Effect of antiprogestin RU 486 on the proliferation and metabolic activity of stromal cells separated from human endometrium. Contraception 53: 127-131, 1996
3. Burleigh DW, Williams RF, Gordon K, Hsiu JG, Hodgen GD: Screeing for antiproliferative actions of mifepristone. Differential endometrial responses of primates versus rats. Contraception 58: 45-50, 1998
4. Chen G, Huang JR, Mazella J, Tseng L: Long-term effects of progestin and RU 486 on prolactin production and synthesis in human endometrial stromal cells. Hum Reprod 4: 355-358, 1989
5. Daly DC, Maslar IA, Riddick DH: Prolactin production during in vitro decidualization of proliferative endometrium. Am J Obstet Gynecol 145: 672-678, 1983
6. Felix JC, Farahmand S: Endometrial glandular proliferation and estrogen receptor content during the normal menstrual cycle. Contraception 55: 19-22, 1997
7. Ferenczy A, Bertrand G, Gelfand MM: Proliferation kinetics of human endometrium during the normal menstrual cycle. Am J Obstet Gynecol 133: 859-867, 1997
8. Gemzell-Danielsson K, Westlund P, Johannisson E, Swahn ML, Bygdeman M, Seppälä M: Effect of low weekly doses of mifepristone on ovarian function and endometrial development. Hum Reprod 11: 256-264, 1996
9. Gentry MK, Dalrymple JM: Quantitative microtiter cytotoxicity assay for shigella toxin. J Clin Microbiol 12: 361-366, 1980
10. Gravanis A, Schaison G, George M, De Brux J, Satyaswaroop PG, Baulieu EE, Robel P: Endometrial and pituitary responses to the steroidal antiprogestin RU 486 in postmenopausal women. J Clin Endocrinol Metab 60: 156-163, 1985
11. Greb RR, Kiesel L, Selbmann AK, Wehrmann M, Hogen GD, Goodman Al, Wallwiener D: Disparate actions of mifepristone (RU 486) on glands and stroma in the primate endometrium. Hum Reprod 14: 198-206, 1999
12. Healy DL: Endometrial prolactin and implantation. Baillieres Clin Obstet Gynecol 5: 95-105, 1991
13. Heikinheimo O, Hsiu JG, Gordon K, Kim S, Williams RF, Gibbons WE, Hodgen GD: Endometrial effects of RU 486 in primates - antiproliferative action despite signs of estrogen action and increased Caclin-B expression. J Steroid Biochem Mol Biol 59: 179-190, 1996
14. Huang JR, Tseng L, Bischof P, Janne OA: Regulation of prolactin production by progestin, estrogen, and relaxin in human endometrial stromal cells. Endocrinology 121: 2011-2017, 1987
15. Irwin JC, Kirk D, King RJ, Quigley MM, Gwatkin RB: Hormonal regulation of human endometrial stromal cells in culture: an in vitro model for decidualization. Fertil Steril 52: 761-768, 1989
16. Irwin JC, Utian WH, Eckert RL: Sex steroids and growth factors differentially regulate the growth and differentiation of cultured human endometrial stromal cells. Endocrinology 129: 2385-2392, 1991
17. Jabbour HN, Critchley HO, Boddy SC: Expression of functional prolactin receptors in nonpregnant human endometrium: janus kinase-2, signal transducer and activator of transcription-1 (STAT1), and STAT5 proteins are phosphorylated after stimulation with prolactin. J Clin Endocrinol Metab 83: 2545-2553, 1998
18. Jones RL, Critchley HO, Brooks J, Jabbour NH, McNeilly AS: Localization and temporal expression of prolactin receptor in human endometrium. J Clin Endocrinol Metab 83: 258-262, 1998
19. Kettel LM, Murphy AA, Morales AJ, Ulmann A, Baulieu EE, Yen SSC: Treatment of endometriosis with the antiprogesterone mifepristone (RU 486). Fertil Steril 65: 23-28, 1996
20. Kiesel L, Mappes M: Regulation of endometrial differentiation by synthetic steroids in vitro. Ann NY Acad Sci 734: 237-244, 1994
21. Lobacco-Henri C, Descomps B, Thaler-Dao H: RU 38486 inhibits intracellular calcium mobilization and PG12 release from human myometrium: mechanisms of action. J Steroid Biochem Mol Biol 59: 63-73, 1996
22. Mäentausta O, Svalander P, Gemzell-Danielsson K, Bygdeman M, Vihko R: The effects of an antiprogestin, mifepristone, and an antiestrogen, tamoxifen, on endometrial 17 beta-hydroxysteroid dehydrogenase and progestin and estrogen receptors during the luteal phase of the menstrual cycle: an immunohistochemical study. J Clin Endocrinol Metab 77: 913-918, 1993
23. Mappes M: Parakrine und autokrine Wirkmechanismen bei der Proliferation und Differenzierung von Endometrium- und Endometriosezellen in Kultur. Inauguraldissertation zur Erlangung des Doktorgrades scientiarum humanarum der Fakultät für klinische Medizin I der Medizinische Gesamtfakultät der Ruprecht-Karls-Universität Heidelberg1993
24. Marions L, Danielsson KG, Swahn ML, Bygdeman M: Contraceptive efficacy of low doses of mifepristone. Fertil Steril 70: 813-816, 1998
25. Maslar IA, Riddick DH: Prolactin production by human endometrium during the normal menstrual cycle. Am J Obstet Gynecol 135: 751-754, 1979
26. Meyer ME, Pornon A, Ji JW, Bocquel MT, Chambon P, Gronemeyer H: Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. EMBO J 9: 3923-3932, 1990
27. Musgrove EA, Lee CS, Cornish AL, Swarbrick A, Sutherland RL: Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21. Mol Endocrinol 11: 54-66, 1997
28. Pecci A, Scholz A, Pelster D, Beato M: Progestins prevent apoptosis in a rat endometrial cell line and increases the ratio of bcl-XL to bcl-XS. J Biol Chem 272: 11791-11798, 1997
29. Perusquia M, Kubli-Garfias C: Progesterone-like relaxant effect of RU 486 in the rat myometrium. Life Sci 54: 1501-1506, 1994
30. Schneider CC, Gibb RK, Taylor DD, Wan T, Gercel-Taclor C: Inhibition of endometrial cancer cell lines by mifepristone (RU 486). J Soc Gynecol Investig 5: 334-338, 1998
31. Slayden OD, Brenner RM: RU 486 action after estrogen priming in the endometrium and oviducts of Rhesus monkeys (Macaca mullatta). J Clin Endocrinol Metab 78: 440-448, 1994
32. Swahn ML, Bygdeman M, Cekan S, Xing S, Masironi B, Johannisson E: The effect of RU 486 administered during the early luteal phase on bleeding pattern, hormonal parameters and endometrium. Hum Reprod 5: 402-408, 1990
33. Tseng L, Mazella J: Prolactin and its receptor in human endometrium. Semin Reprod Endocrinol 17: 23-27, 1999
34. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB: Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 7: 1256-1265, 1993
35. Viville B, Charnock-Jones DS, Sharkey AM, Wetzka B, Smith SK: Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leimyomata and adjacent myometrium. Hum Reprod 12: 815-822, 1997
36. Wolf JP, Hsiu JG, Anderson TL, Ulmann A, Baulieu EE, Hodgen GD: Noncompetitive antiestrogenic effect of RU 486 in blocking the estrogen stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrated monkeys. Fertil Steril 52: 1055-1060, 1989
37. Xiao CW, Goff AK: Hormonal regulation of estrogen and progesterone receptors in cultured bovine endometrial cells. J Reprod Fertil J 15: 101-109, 1999