Associations of delirium with in-hospital and in 6-months mortality in elderly medical inpatients

Age and Ageing

Volumn 36, Issue 6, 2007, Pages 644-649

  Adamis, Dimitrios ^a,b,c   Treloar, Adrian ^b,c   Darwiche, Fai Zaza ^a   Gregson, Norman ^b   Macdonald, Alastair J D ^b   Martin, Finbarr C ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c OXLEAS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Albumin; CRP; Cytokines; Delirium; Elderly; Frailty; Mortality; Outcome

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 6;

AGED; AGING; ALBUMIN BLOOD LEVEL; ARTICLE; CLINICAL EVALUATION; COHORT ANALYSIS; CONTROLLED STUDY; DELIRIUM; DISEASE ASSOCIATION; DISEASE SEVERITY; ELDERLY CARE; FEMALE; HOSPITAL ADMISSION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; LABORATORY TEST; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MORTALITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALBUMINS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; DATA INTERPRETATION, STATISTICAL; DELIRIUM; FEMALE; HOSPITAL MORTALITY; HUMANS; INPATIENTS; INTERLEUKIN-6; LOGISTIC MODELS; MALE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES;

EID: 37149031190     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afm094     Document Type: Article

References (29)

1. Siddiqi N, House AO, Holmes JD. Occurrence and outcome of delirium in medical in patients: A systematic literature review. Age Ageing 2006; 35: 350-64.
2. O'Keeffe S, Lavan J. The prognostic significance of delirium in older hospital patients. J Am Geriatr Soc 1997; 45: 174-8.
3. Adamis D, Treloar A, Martin FC, Macdonald AJD. Recovery and outcome of delirium in elderly medical inpatients. Arch Gerontol Geriatr 2006; 43: 289-98.
4. Inouye SK, Rushing JT, Foreman MD, Palmer RM, Pompei P. Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. J Gen Intern Med 1998; 13: 234-42.
5. Rockwood K, Cosway S, Carver D, Jarrett P, Stadnyk K, Fisk J. The risk of dementia and death after delirium. Age Ageing 1999a; 28: 551-6.
6. Curyto KJ, Johnson J, TenHave T, Mossey J, Knott K, Katz IR. Survival of hospitalized elderly patients with delirium: A prospective study. Am J Geriatr Psychiatry 2001; 9: 141-7.
7. McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E. Delirium predicts 12-month mortality. Arch Intern Med 2002; 162: 457-63.
8. Francis J, Kapoor WN. Prognosis after hospital discharge of older medical patients with delirium. J Am Geriatr Soc 1992; 40: 601-6.
9. Cole MG, Primeau FJ. Prognosis of delirium in elderly hospital patients. CMAJ 1993; 149: 41-6.
10. Campbell SE, Seymour DG, Primrose WR, for the ACMEplus Project. A systematic literature review of factors affecting outcome in older medical patients admitted to hospital. Age Ageing 2004; 33: 1-6.
11. Iwata M, Kuzuya M, Kitagawa Y, Iguchi A. Prognostic value of serum albumin combined with serum C-reactive protein levels in older hospitalized patients: Continuing importance of serum albumin. Aging Clin Exp Res 2006; 18: 307-11.
12. Reuben DB, Ferrucci L, Wallace R et al. The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels. J Am Geriatr Soc 2000; 48: 1404-7.
13. Macdonald A, Adamis D, Treloar A, Martin F. C-reactive protein levels predict the incidence of delirium and recovery from it. Age Ageing 2007; 36: 222-5.
14. Adamis D, Treloar A, Martin FC, Gregson N, Hamilton G, Macdonald AJD. APOE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients. Int J Geriatr Psychiatry 2007; 21: 1-7.
15. Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert R, Hogan DB. A brief clinical instrument to classify frailty in elderly people. Lancet 1999; 353: 205-6.
16. Adamis D, Martin FC, Treloar A, Macdonald AJD. Capacity, consent, and selection bias in a study of delirium. J Med Ethics 2005; 31: 137-43.
17. Balan S, Leibovitz; A, Freedman L et al. Stasonal variation in the incidence of delirium among the patients of a geriatric hospital. Arch Gerontol Geriatr 2001; 33: 287-93.
18. Silvestri A, Vitale C, Ferretti F, Onorati D, Fini M, Rosano GM. Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in elderly patients with stroke. J Am Geriatr Soc 2004; 52: 1586-7.
19. Volpato S, Guralnik JM, Ferrucci L et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: The women's health and aging study. Circulation 2001; 103: 947-53.
20. Roubenoff R, Parise H, Payette HA et al. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: The Framingham Heart Study. Am J Med 2003; 115: 429-35.
21. Evrin PE, Nilsson SE, Oberg T, Malmberg B. Serum C-reactive protein in elderly men and women: Association with mortality, morbidity and various biochemical values. Scand J Clin Lab Invest 2005; 65: 23-31.
22. Binkley NC, Sun WH, Checovich MM, Roecker EB, Kimmel DB, Ershler WB. Effects of recombinant human interleukin-6 administration on bone in rhesus monkeys. Lymphokine Cytokine Res 1994; 13: 221-6.
23. Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jorgensen T, Pedersen BK. Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol 2003; 132: 24-31.
24. Lindesay J, Rockwood K, Macdonald A. Delirium in Old Age. Oxford, New York: Oxford University Press. 2002.
25. Godbout JP, Johnson RW: Interleukin-6 in the aging brain. J Neuroimmunol 2004; 147: 141-4.
26. De Simone R, Levi G, Aloisi F. Interferon gamma gene expression in rat central nervous system glial cells, Cytokine 1998; 10: 418-22.
27. Aneshensel CS, Pearlin LI, Levy-Storms L, Schuler RH. The transition from home to nursing home mortality among people with dementia. J Gerontol B Psychol Sci Soc Sci 2000; 55: S152-62.
28. van Dijk PT, varr de Sande HJ, Dippel DW, Habbema JD. The nature of excess mortality in nursing home patients with dementia. J Gerontol 1992; 47: M28-34.
29. Shapiro E, Tate R. Survival patterns of nursing home admissions and their policy implications. Can J Public Health 1988; 79: 268-74.