Capacity, consent, and selection bias in a study of delirium

Journal of Medical Ethics

Volumn 31, Issue 3, 2005, Pages 137-143

  Adamis, Dima ^a   Martin, F C ^b   Treloar, A ^c   Macdonald, A J D ^c  

^a Academic Department   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DELIRIUM; DISEASE SEVERITY; FEMALE; GERIATRIC PATIENT; HOME CARE; HOSPITAL ADMISSION; HOSPITAL DEPARTMENT; HOSPITAL DISCHARGE; HOSPITAL PATIENT; HOSPITAL SERVICE; HUMAN; INFORMATION PROCESSING; INFORMED CONSENT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; MENTAL CAPACITY; PATIENT SELECTION; PREVALENCE; PROBABILITY; RANDOMIZATION; SAMPLING; TEACHING HOSPITAL; UNITED KINGDOM;

BIOMEDICAL AND BEHAVIORAL RESEARCH; EMPIRICAL APPROACH;

AGED; DELIRIUM; FEMALE; HUMANS; INFORMED CONSENT; MALE; MENTAL COMPETENCY; PATIENT SELECTION; RESEARCH DESIGN; SELECTION BIAS;

EID: 12144277192     PISSN: 03066800     EISSN: None     Source Type: Journal    
DOI: 10.1136/jme.2002.000919     Document Type: Article

References (36)

1. Pompei P, Foreman M, Rudberg MA, et al. Delirium in hospitalized older persons: outcomes and predictors. J Am Geriatr Soc 1994;42:809-15.
2. O'Keefe ST, Lavan JN. The prognostic significance of delirium in older hospital patients. J Am Geriatr Soc 1997; 45 174-8.
3. Inouye SK. The dilemma of delirium: clinical and research controversies regarding diagnosis and evaluation of delirium in hospitalized elderly medical patients. Am J Med 1994;97 278-88.
4. Inouye SK, Viscoli CM, Horwitz RI, et al. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med 1993;119 474-81.
5. Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA 1996; 275 852-7.
6. Elie M, Cole MG, Primeou FJ, et al. Delirium risk factors in elderly hospitalized patients. J Gen Intern Med 1998; 13:204-12.
7. Inouye SK, Rushing JT, Foreman MD, et al. Does delirium contribute to poor hospital outcome? A three site epidemiological study. J Gen Intern Med 1998;13:234-42.
8. Levkoff SE, Evans DA, Liptzin B, et al. The occurrence and persistence of symptoms among elderly hospitalised patients. Arch Intern Med 1992;152:334-40.
9. Francis J, Kapoor WN. Prognosis after hospital discharge of older medical patients with delirium. J Am Geriatr Soc 1992;40:601-6.
10. Inouye SK, Bogardus ST Jr, Charpentier PA, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 1999;340:669-76.
11. Britton A, Russell R. Multidisciplinary team interventions for delirium in patients with chronic cognitive impairment (Cochrane Review). In:Cochrane Library, Issue 4. Oxford: Update Software, 2000.
12. Treloar AJ, Macdonald AJD. Outcome of delirium: 2. Clinical features of reversible cognitive dysfunction - are they the same as accepted definitions of delirium? Int J Geriatr Psychiatry 1997;12:614-18.
13. Macdonald AJ, Treloar A. Delirium and dementia; are they distinct? J Am Geriatr Soc 1997;44:1001-2.
14. Koponen HJ. Neurochemistry and delirium. Dement Geriatr Cogn Disord 1999;10:339-41.
15. Treloar A, Macdonald A. Outcome of delirium: Part 1. Outcome of delirium diagnosed by DSM-III-R, ICD-10 and CAMDEX and derivation of the Reversible Cognitive Dysfunction Scale among acute geriatric inpatients. Int J Geriatr Psychiatry 1997;12 609-13.
16. Bugeja G, Kumar A, Banerjee AK. Exclusion of elderly people from clinical research: a descriptive study of published reports. BMJ 1997;315:1059.
17. British Medical Association and The Law Society. Assessment of Mental Capacity. Guidance for Doctors and Lawyers. London: BMA, 1995.
18. Department of Health. Reference Guide for Consent for Examination or Treatment. London: The Stationery Office, 2001.
19. Medical Research Council. The Ethical Conduct of Research on the Mentally Incapacitated. London: Medical Research Council, 1993.
20. Mukherjee S, Shah A. Capacity to consent: issues and controversies. Hosp Med 2001;62:351-4.
21. Appelbaum PS. Rethinking the conduct of psychiatric research. Arch Gen Psychiatry 1997;54:117-20.
22. Fitten LJ, Waite MS. Impact of medical hospitalization on treatment decision-making capacity in the elderly. Arch Intern Med 1990;150:1717-21.
23. Auerswald KB, Charpentier PA, Inouye SK. The informed consent process in older patients who developed delirium: a clinical epidemiologic study. Am J Med 1997;103:410-18.
24. Inouye SK. Delirium in hospitalized older patients: recognition and risk factors. J Geriatr Psychiatry Neurol 1998; 11:118-25.
25. Levkoff SE, Safran C, Cleary PD, et al. Identification of factors associated with the diagnosis of delirium in elderly hospitalized patients. J Am Geriatr Soc 1988;36 1099-104.
26. World Medical Association Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects. as amended by the 52nd WMA General Assembly, Edinburgh: October, 2000.
27. Capron AM. Ethical and human rights issues in research on mental disorders that might affect decision making capacity. N Engl J Med 1999;340:1430-4.
28. Marcantonio ER, Flacker JM, Wright RJ, et al. Reducing delirium after hip fracture: a randomised trial. J Am Geriatr Soc 2001;49:516-22.
29. Inouye SK, van Dyck CH, Alessi CA, et al. Clarifying confusion: The Confusion Assessment method. Ann Intern Med 1990;113:941-8.
30. Trzepacz PT, Dew MA. Further analyses of the Delirium Rating Scale. Gen Hosp Psychiatry 1995;17:75-9.
31. Folstein MF, Folstein SE, Mc Hugh PR. Mini-mental state: a practical method for grading the cognitive state for the clinician. J Psychiatr Res 1975;12:189-98.
32. Jorm AF, Jacobs PA. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med 1989;19 1015-22.
33. Jorm AF. A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validation. Psychol Med 1994;24:145-53.
34. Knaus WA, Drapes EA, Wagnes DP, et al. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13:818-29.
35. Katz S, Downs TD, Cash HR, et al. Progress in development of the index of ADL. Gerontologist 1970; 10:20-30.
36. Olde Rikkert MGM, van den Bercken JHL, ten Have HAMJ, et al. Experienced consent in geriatrics research: a new method to optimise the capacity to consent in frail elderly subjects. J Med Ethics 1997;23:271-6.