Subclinical hypothyroidism, hyperhomocysteinemia and dyslipidemia: Investigating links with ischemic stroke in Turkish patients

Neurological Research

Volumn 29, Issue 8, 2007, Pages 871-876

  Goksel, Basak Karakurum ^a   Karatas, Mehmet ^a   Nebioglu, Asuman ^a   Sezgin, Nurzen ^a   Tan, Meliha ^a   Seydaoglu, G ^b   Benli, Sibel ^a   Karaca, Sibel ^a   Arlier, Zulfikar ^a   Yerdelen, D ^a  

^a BASKENT UNIVERSITY   (Turkey)

^b CUKUROVA UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

HDL cholesterol; Hyperhomocysteinemia; Hypothyroidism; Ischemic stroke

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; THYROTROPIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CEREBROVASCULAR ACCIDENT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DYSLIPIDEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; HYPERTENSION; HYPOTHYROIDISM; IMMUNOASSAY; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; SCREENING; SMOKING; THYROID HORMONE BLOOD LEVEL; TURKEY (REPUBLIC);

AGED; DYSLIPIDEMIAS; FEMALE; FOLIC ACID; HUMANS; HYPERHOMOCYSTEINEMIA; IMMUNOASSAY; ISCHEMIA; MALE; MIDDLE AGED; RISK FACTORS; STATISTICS, NONPARAMETRIC; THYROTROPIN; TURKEY; VITAMIN B 12;

EID: 37149024199     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164107X181833     Document Type: Article

References (33)

1. Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999; 354: 407-413
2. Meiklejohn DJ, Vickers MA, Dijkhuisen R, et al. Plasma homocysteine concentrations in the acute and convalescent periods of atherotrombotic stroke. Stroke 2001; 32: 57-62
3. Bautista LE, Arenas IA, Penuela A, et al. Total plasma homocysteine level and risk of cardiovascular disease: A meta-analysis of prospective cohort studies. J Clin Epidemiol 2002; 55: 882-887
4. Tan NC, Venketasubramanian N, Saw SM, et al. Hyperhomocysteinemia and risk of ischemic stroke among young Asian adults. Stroke 2002; 33: 1956-1962
5. Morris SM, Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentration is related to self-reported heart attack or stroke history among men and women in the NHANES III. J Nutr 2000; 130: 3073-3076
6. Eikelboom JW, Hankey GJ, Anand SS, et al. Association between high homocysteine and ischemic stroke due to large and small artery disease but not other etiological subtypes of ischemic stroke. Stroke 2000; 31: 1069-1075
7. Parnetti L, Caso V, Santucci A, et al. Mild hyperhomocysteinemia is a risk factor in all etiological subtypes of stroke. Neurol Sci 2004; 25: 13-17
8. Sacco RL, Anand K, Lee HS, et al. Homocysteine and the risk of ischemic stroke in a triethnic cohort. Stroke 2004; 35: 2263-2269
9. Graham IM, Daly LE, Refsum H. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997; 277: 1775-1781
10. Schwammenthal Y, Tanne D. Homocysteine, B-vitamin supplementation, and stroke prevention: From observational to interventional trials. Lancet Neurol 2004; 3: 493-495
11. Becerra A, Bellido D, Luengo A, et al. Lipoprotein (a) and other lipoproteins in hypothyroid patients before and after thyroid replacement therapy. Clin Nutr 1999; 18: 319-322
12. Hak AE, Pols HA, Visser TJ, et al. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: The Rotterdam Study. Ann Intern Med 2000; 132: 270-278
13. Muller M, Tsakiris DA, Royh CB, et al. Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease. Eur J Clin Invest 2001; 31: 131-137
14. Lekakis JP, Papamichael CM, Alevizaki MK, et al. Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis. Am J Cardiol 2000; 85: 949-952
15. Berenson GS, Srinivasan SR. Emergence of obesity and cardiovascular risk for coronary artery disease: The Bogalusa Heart Study. Prev Cardiol 2001; 4: 116-121
16. Diekman MJM, van der Put NM, Blom HJ, et al. Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism. Clin Endocrinol 2001; 54: 197-204
17. Welch GN, Loscalzo J. Mechanisms of disease: Homocysteine and atherothrombosis. N Engl J Med 1998; 338: 1042
18. Atabek ME, Pirgon O, Erkul I. Plasma homocysteine concentrations in adolescents with subclinical hypothyroidism. J Pediatr Endocrinol Metab 2003; 16: 1245-1248
19. Morris MS, Bostom AG, Jacques PF, et al. Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US National Health and Nutrition Examination Survey. Atherosclerosis 2001; 155: 195-200
20. Krausz Y, Freedman N, Lester H, et al. Regional cerebral blood flow in patients with mild hypothyroidism. J Nucl Med 2004; 45: 1712-1715
21. Patterson JS, Rusley MS, Zachary JF. Neurologic manifestations of cerebrovascular atherosclerosis associated with primary hypothyroidism in a dog. J Am Vet Med Assoc 1985; 186: 499-503
22. Dierkes J, Westphal S, Kunstmann S, et al. Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate. Atherosclerosis 2001; 158: 161-164
23. Selhub J, Jacques PF, Wilson PW, et al. Vitamin status and intake as primary determinant of homocysteinemia in an elderly population. JAMA 1993; 270: 2693-2698
24. Al-Delaimy WK, Rexrode KM, Hu FB, et al. Folate intake and risk of stroke among women. Stroke 2004; 35: 1-5
25. Hussein WI, Green R, Jocobsen DW, et al. Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism. Ann Intern Med 1999; 131: 348-351
26. Hueston WJ, Pearson WS. Subclinical hypothyroidism and the risk of hypercholesterolemia. Ann Fam Med 2004; 2: 351-355
27. Nagasaki T, Inaba M, Henmi Y, et al. Decrease in carotid intima-media thickness in hypothyroid patients after normalization of thyroid function. Clin Endocrinol (Oxf) 2003; 59: 607-612
28. Lien EA, Nedrebo BG, Varhaug JE, et al. Plasma total homocysteine levels during short-term iatrogenic hypothyroidism. J Clin Endocrinol Metab 2000; 85: 1049-1053
29. Altaus BU, Staub JJ, Ryff-De Leche A, et al. LDL/HDL-changes in subclinical hypothyroidism: Possible risk factors for coronary artery disease. Clin Endocrinol (Oxf) 1988; 28: 157-163
30. Aldasouqi S, Nkansa-Dwamena D, Bokhari S, et al. Is subclinical hypothyroidism associated with hyperhomocysteinemia. Endocr Pract 2004; 10: 399-403
31. Atabek ME, Pirgon O, Erkul I. Plasma homocysteine concentrations in adolescents with subclinical hypothyroidism. J Pediatr Endocrinol Metab 2003; 16: 1245-1248
32. Iwashita M, Matsushita Y, Sasaki J, et al. Relation of serum total cholesterol and other factors to risk of cerebral infarction in Japanese men with hypercholesterolemia. Circ J 2005; 69: 1-6
33. Rodandi N, Newman AB, Vittinghoff E, et al. Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med 2005; 165: 2460-2466