Survivin mRNA antagonists using locked nucleic acid, potential for molecular cancer therapy

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 10-12, 2007, Pages 1427-1430

  Fisker, Niels ^a   Westergaard, Majken ^a   Hansen, Henrik Frydenlund ^a   Hansen, Jens Bo ^a  

^a Santaris Pharma AS   (Denmark)

Author keywords

Antisense; LNA; Locked nucleic acid; mRNA; Survivin

Indexed keywords

COMPLEMENTARY RNA; LOCKED NUCLEIC ACID; MESSENGER RNA; PACLITAXEL; PROTEIN INHIBITOR; SPC 2764; SPC 3042; SURVIVIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; IN VIVO STUDY; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; OLIGONUCLEOTIDES; PROSTATIC NEOPLASMS; RNA, ANTISENSE; RNA, MESSENGER;

EID: 36949022264     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701542132     Document Type: Article

References (5)

1. Altieri, D.C. Validating survivin as a cancer therapeutic target. Nat. Rev. Cancer 2003, 3, 46-54.
2. Olie, R.A.; Simoes-Wust, A.P.; Baumann, B.; Leech, S.H.; Fabbro, D.; Stahel, R.A.; Zangemeister-Wittke, U. A novel antisense oligonucleotide targeting Survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res. 2000, 60, 2805-2809.
3. Shinohara, E.T.; Hallahan, D.E.; Lu, B. The use of antisense oligonucleotides in evaluating Survivin as a therapeutic target for radiation sensitization in lung cancer. Biol. Proced. Online 2004, 6, 250-256.
4. Grunweller, A.; Wyszko, E.; Bieber, B.; Jahnel, R.; Erdmann, V.A.; Kurreck, J. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. 2003, 31, 3185-3193.
5. Wahlestedt, C.; Salmi, P.; Good, L.; Kela, J.; Johnsson, T.; Hokfelt, T.; Broberger, C.; Porreca, F.; Lai, J.; Ren, K.; Ossipov, M.; Koshkin, A.; Jakobsen, N.; Skouv, J.; Oerum, H.; Jacobsen, M.H.; Wengel, J. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc. Natl. Acad. Sci. USA 2000, 97, 5633-5638.