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Volumn 35, Issue 6, 2007, Pages 803-818

Activation of the calcineurin/NFAT signalling cascade starts early in human hypertrophic myocardium

Author keywords

Calcineurin; GATA 4; Heart failure; Human Myocardium; Hypertrophy; NFAT 3

Indexed keywords

CALCINEURIN; CALCINEURIN B; CALCINEURIN BETAA; CALCIUM ION; ESTERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT3; UNCLASSIFIED DRUG;

EID: 36949013409     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000703500609     Document Type: Article
Times cited : (22)

References (33)
  • 1
    • 0025280867 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study
    • Levy D, Garrison RJ, Savage DD, et al: Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study. N Engl J Med 1990; 322: 1561-1566.
    • (1990) N Engl J Med , vol.322 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3
  • 2
    • 0001229903 scopus 로고    scopus 로고
    • Alterations in calcium handling in cardiac hypertrophy and heart failure
    • Balke CW, Shorofsky SR: Alterations in calcium handling in cardiac hypertrophy and heart failure. Cardiovasc Res 1998; 37: 290-299.
    • (1998) Cardiovasc Res , vol.37 , pp. 290-299
    • Balke, C.W.1    Shorofsky, S.R.2
  • 3
    • 0026542534 scopus 로고
    • Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure
    • Beuckelmann DJ, Nabauer M, Erdmann E: Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 1992; 85: 1046-1055.
    • (1992) Circulation , vol.85 , pp. 1046-1055
    • Beuckelmann, D.J.1    Nabauer, M.2    Erdmann, E.3
  • 4
    • 0028882650 scopus 로고
    • 2+-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts
    • 2+-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. Circulation 1995; 92: 3220-3228.
    • (1995) Circulation , vol.92 , pp. 3220-3228
    • Schwinger, R.H.G.1    Böhm, M.2    Schmidt, U.3
  • 5
    • 0023189660 scopus 로고
    • Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure
    • Gwathmey JK, Copelas L, MacKinnon R, et al: Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 1987; 61: 70-76.
    • (1987) Circ Res , vol.61 , pp. 70-76
    • Gwathmey, J.K.1    Copelas, L.2    MacKinnon, R.3
  • 6
    • 0023684188 scopus 로고
    • Reversal of the force-frequency relationship in working myocardium from patients with end-stage heart failure
    • Feldman MD, Gwathmey JK, Phillips P, et al: Reversal of the force-frequency relationship in working myocardium from patients with end-stage heart failure. J Appl Cardiol 1988; 3: 273-283.
    • (1988) J Appl Cardiol , vol.3 , pp. 273-283
    • Feldman, M.D.1    Gwathmey, J.K.2    Phillips, P.3
  • 7
    • 85047680836 scopus 로고
    • Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy
    • Limas CJ, Olivari MT, Goldenberg IF, et al: Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy. Cardiovasc Res 1987; 21: 601-605.
    • (1987) Cardiovasc Res , vol.21 , pp. 601-605
    • Limas, C.J.1    Olivari, M.T.2    Goldenberg, I.F.3
  • 8
    • 0032540267 scopus 로고    scopus 로고
    • A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    • Molkentin JD, Lu JR, Antos CL, et al: A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998; 93: 215-228.
    • (1998) Cell , vol.93 , pp. 215-228
    • Molkentin, J.D.1    Lu, J.R.2    Antos, C.L.3
  • 9
    • 0033982992 scopus 로고    scopus 로고
    • Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo
    • De Windt LJ, Lira HW, Taigen T, et al: Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. Circ Res 2000; 86: 255-263.
    • (2000) Circ Res , vol.86 , pp. 255-263
    • De Windt, L.J.1    Lira, H.W.2    Taigen, T.3
  • 10
    • 0035814747 scopus 로고    scopus 로고
    • Differential activation of signal transduction pathway in human hearts with hypertrophy versus advanced heart failure
    • Haq S, Choukroun G, Lira H, et al: Differential activation of signal transduction pathway in human hearts with hypertrophy versus advanced heart failure. Circulation 2001; 103: 670-677.
    • (2001) Circulation , vol.103 , pp. 670-677
    • Haq, S.1    Choukroun, G.2    Lira, H.3
  • 11
    • 0033054549 scopus 로고    scopus 로고
    • Calcineurin and human heart failure
    • Lim HW, Molkentin JD: Calcineurin and human heart failure. Nat Med 1999; 5: 246-247.
    • (1999) Nat Med , vol.5 , pp. 246-247
    • Lim, H.W.1    Molkentin, J.D.2
  • 12
    • 0842326416 scopus 로고    scopus 로고
    • Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure
    • Diedrichs H, Chi M, Boelck B, et al: Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure. Eur J Heart Fail 2004; 6: 3-9.
    • (2004) Eur J Heart Fail , vol.6 , pp. 3-9
    • Diedrichs, H.1    Chi, M.2    Boelck, B.3
  • 13
    • 0036518563 scopus 로고    scopus 로고
    • Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium
    • Münch G, Boelck B, Karczewski P, et al: Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium. J Mol Cell Cardiol 2002; 34: 321-334.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 321-334
    • Münch, G.1    Boelck, B.2    Karczewski, P.3
  • 14
    • 0028334949 scopus 로고
    • A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues
    • Deryckere F, Gannon F: A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. Biotechniques 1994; 16: 405.
    • (1994) Biotechniques , vol.16 , pp. 405
    • Deryckere, F.1    Gannon, F.2
  • 15
    • 0037076286 scopus 로고    scopus 로고
    • Calcineurin in human heart hypertophy
    • Ritter O, Hack S, Schuh K, et al: Calcineurin in human heart hypertophy. Circulation 2002; 105: 2265-2269.
    • (2002) Circulation , vol.105 , pp. 2265-2269
    • Ritter, O.1    Hack, S.2    Schuh, K.3
  • 16
    • 0032508640 scopus 로고    scopus 로고
    • Prevention of cardiac hypertrophy in mice by calcineurin inhibition
    • Sussman MA, Lim HW, Gude N, et al: Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 1998; 281: 1690 -1693.
    • (1998) Science , vol.281 , pp. 1690-1693
    • Sussman, M.A.1    Lim, H.W.2    Gude, N.3
  • 17
    • 0034705070 scopus 로고    scopus 로고
    • Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy
    • Lim HW, De Windt LI, Steinberg L, et al: Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation 2000; 101: 2431-2437.
    • (2000) Circulation , vol.101 , pp. 2431-2437
    • Lim, H.W.1    De Windt, L.I.2    Steinberg, L.3
  • 18
    • 0034625078 scopus 로고    scopus 로고
    • Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training
    • Eto Y, Yonekura K, Sonda M, et al: Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training. Circulation 2000; 101: 2134-2137.
    • (2000) Circulation , vol.101 , pp. 2134-2137
    • Eto, Y.1    Yonekura, K.2    Sonda, M.3
  • 19
    • 0034709643 scopus 로고    scopus 로고
    • Cardiac calcineurin during transition from hypertrophy to heart failure in rats
    • Hayashida W, Kihara Y, Yasaka A, et al: Cardiac calcineurin during transition from hypertrophy to heart failure in rats. Biochem Biophys Res Commun 2000; 273: 347-351.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 347-351
    • Hayashida, W.1    Kihara, Y.2    Yasaka, A.3
  • 20
    • 0032762988 scopus 로고    scopus 로고
    • Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy
    • Shimoyama M, Hayashi D, Takimoto E, et al: Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. Circulatian 1999; 100: 2449-2454.
    • (1999) Circulatian , vol.100 , pp. 2449-2454
    • Shimoyama, M.1    Hayashi, D.2    Takimoto, E.3
  • 21
    • 0033515619 scopus 로고    scopus 로고
    • Pressure overload induces severe hypertrophy in mice treated with cyclosporin, an inhibitor of calcineurin
    • Ding B, Price RL, Borg TK, et al: Pressure overload induces severe hypertrophy in mice treated with cyclosporin, an inhibitor of calcineurin. Circ Res 1999; 84: 729-734.
    • (1999) Circ Res , vol.84 , pp. 729-734
    • Ding, B.1    Price, R.L.2    Borg, T.K.3
  • 22
    • 0033515618 scopus 로고    scopus 로고
    • Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats
    • Zhang W, Kowal RC, Rusnak F, et al: Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. Circ Res 1999; 84: 722-728.
    • (1999) Circ Res , vol.84 , pp. 722-728
    • Zhang, W.1    Kowal, R.C.2    Rusnak, F.3
  • 23
    • 0037095815 scopus 로고    scopus 로고
    • Calcineurin and cardiac hypertrophy: Where have we been? Where are we going?
    • Wilkins BJ, Molkentin JD: Calcineurin and cardiac hypertrophy: Where have we been? Where are we going? J Physiol 2002; 541: 1-8.
    • (2002) J Physiol , vol.541 , pp. 1-8
    • Wilkins, B.J.1    Molkentin, J.D.2
  • 24
    • 0030706186 scopus 로고    scopus 로고
    • Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway
    • Chow CW, Rincón M, Cavanagh J, et al: Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 1997; 278: 1638-1641.
    • (1997) Science , vol.278 , pp. 1638-1641
    • Chow, C.W.1    Rincón, M.2    Cavanagh, J.3
  • 25
    • 0035839475 scopus 로고    scopus 로고
    • The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo
    • Liang QG, De Windt LJ, Witt SA, et al: The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem 2001; 276: 30245-30253.
    • (2001) J Biol Chem , vol.276 , pp. 30245-30253
    • Liang, Q.G.1    De Windt, L.J.2    Witt, S.A.3
  • 26
    • 0033525748 scopus 로고    scopus 로고
    • 2+, calcineurin and NFAT
    • 2+, calcineurin and NFAT. Cell 1999; 96: 611-614.
    • (1999) Cell , vol.96 , pp. 611-614
    • Crabtree, G.R.1
  • 27
    • 0036094148 scopus 로고    scopus 로고
    • Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases
    • Yang TTC, Xiong QF, Enslen H, et al: Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol 2002; 22: 3892-3904.
    • (2002) Mol Cell Biol , vol.22 , pp. 3892-3904
    • Yang, T.T.C.1    Xiong, Q.F.2    Enslen, H.3
  • 28
    • 0035860698 scopus 로고    scopus 로고
    • Calcineurin-GATA4 pathway is involved in β-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes
    • Morimoto T, Hasegawa K, Wada H, et al: Calcineurin-GATA4 pathway is involved in β-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes. J Biol Chem 2001; 276: 34983-34989.
    • (2001) J Biol Chem , vol.276 , pp. 34983-34989
    • Morimoto, T.1    Hasegawa, K.2    Wada, H.3
  • 29
    • 0030698652 scopus 로고    scopus 로고
    • cis-Acting sequences that mediate induction of β-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction
    • Hasegawa K, Lee SJ, Jobe S, et al: cis-Acting sequences that mediate induction of β-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. Circulation 1997; 96: 3943-3953.
    • (1997) Circulation , vol.96 , pp. 3943-3953
    • Hasegawa, K.1    Lee, S.J.2    Jobe, S.3
  • 30
    • 0030612599 scopus 로고    scopus 로고
    • Angiotensin II type Iα receptor gene expression in the heart: AP-1 and GATA-4 participate in the responses to pressure overload
    • Herzig TC, Jobe SM, Aoki H: Angiotensin II type Iα receptor gene expression in the heart: AP-1 and GATA-4 participate in the responses to pressure overload. Proc Natl Acad Sci USA 1997; 94: 7543-7548.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7543-7548
    • Herzig, T.C.1    Jobe, S.M.2    Aoki, H.3
  • 31
    • 0032577483 scopus 로고    scopus 로고
    • Regulation of the calmodulin-stimulated protein phosphatase, calcineurin
    • Klee CB, Ren H, Wang X: Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 1998; 273: 13367-13370.
    • (1998) J Biol Chem , vol.273 , pp. 13367-13370
    • Klee, C.B.1    Ren, H.2    Wang, X.3
  • 32
    • 0033981108 scopus 로고    scopus 로고
    • Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy
    • Taigen T, De Windt LI, Lim HW, et al: Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci USA 2000; 97: 1196-1201,
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1196-1201
    • Taigen, T.1    De Windt, L.I.2    Lim, H.W.3
  • 33
    • 0037047152 scopus 로고    scopus 로고
    • Defective T cell development and function in calcineurin A beta-deficient mice
    • Bueno OF, Brandt EB, Rothenberg ME, et al: Defective T cell development and function in calcineurin A beta-deficient mice. Proc Natl Acad Sci USA 2002; 99: 9398-9403.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9398-9403
    • Bueno, O.F.1    Brandt, E.B.2    Rothenberg, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.