JP-8 jet fuel exposure rapidly induces high levels of IL-10 and PGE2 secretion and is correlated with loss of immune function

Toxicology and Industrial Health

Volumn 23, Issue 4, 2007, Pages 223-230

  Harris, David T ^a   Sakiestewa, Debbie ^a   Titone, Dominic ^a   Witten, Mark ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

hydrocarbon inhalation; IL 10; immunotoxicology; jet fuel; JP 8; PGE2

Indexed keywords

FUEL; INTERLEUKIN 10; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNE SYSTEM; IMMUNOTOXICITY; MOUSE; NONHUMAN; ORGAN WEIGHT;

ANIMALS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; FEMALE; HYDROCARBONS; INHALATION EXPOSURE; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; PYRAZOLES; SULFONAMIDES; TERATOGENS; TIME FACTORS;

MUS;

EID: 36949007175     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233707083956     Document Type: Article

References (30)

1. Chen, H., Witten, M.L., Pfaff, J.K., Lantz, R.C. and Carter, D. 1992: JP-8 jet fuel exposure increases alveolar permeability in rats. The FASEB Journal 6, A1064.
2. Cooper, J.R. and Mattie, D.R. 1996: Developmental toxicity of JP-8 jet fuel in the rat. Journal of Applied Toxicology 16, 197—200.
3. Demeure, C.E., Yang, L.P., Desjardins, C., Raynauld, P. and Delespesse, G. 1997: Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines. European Journal of Immunology 27(12), 3526—31.
4. Dossing, M., Loft, S. and Schroeder, E. 1985: Jet fuel and liver function. Scandinavian Journal of Work, Environment and Health 11, 433—37.
5. Fadok, V.A., Bratton, D.L., Konowal A., Freed, P.W., Westcott, J.Y. and Henson, P.M. 1998: Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2 and PAF. Journal of Clinical Investigation 101(4), 890—98.
6. Fiorentino, D.F., Zlotnik, A., Vieira, P., Mosmann, T.R., Howard, M., Moore, K.W. and O'Garra, A. 1991: IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. Journal of Immunology 146(10), 3444—51.
7. Gaworski, G., MacEwen, J., Vernot, E., Bruner, R. and Cowen, M. 1984: Comparison of the subchronic inhalation toxicity of petroleum and oil shale JP-5 jet fuel. In MacFarland H.N. and Holdsworth C.E., editors, Advances in modern environmental toxicology, volume 6. Princeton Scientific Publishers, Inc., Princeton, NJ, 33—47.
8. Harris, D.T., Schumacher, M.J., LoCascio, J., Besencon, F.J., Olson, G.B., DeLuca, D., Shanker, L., Bard, J. and Boyse, E.A. 1992: Phenotypic and functional immaturity of human umbilical cord blood T-lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 89, 10006—10.
9. Harris, D.T., Sakiestewa, D., Robledo, R.F. and Witten, M. 1997a: Immunotoxicological effects of JP-8 jet fuel exposure. Toxicology and Industrial Health 13(1), 43—55.
10. Harris, D.T., Sakiestewa, D., Robledo, R.F. and Witten, M. 1997b: Short-term exposure to JP-8 jet fuel results in longterm immunotoxicity. Toxicology and Industrial Health 13(5), 559—70.
11. Harris, D.T., Sakiestewa, D., Robledo, R.F., Young, R.C. and Witten M. 2000: Effects of short term JP-8 jet fuel exposure on cell-mediated immunity. Toxicology and Industrial Health 16: 78—84.
12. Hays, A.M., Parliman, G., Pfaff, J.K., Lantz, R.C., Tinajero, J., Tollinger, B., Hall, J.N. and Witten, M.L. 1995: Changes in lung permeability correlates with lung histology in a chronic exposure model. Toxicology and Industrial Health 11(3), 325—26.
13. Herrin, B.R., Haley, J.E., Lantz, R.C. and Witten, M.L. 2006: A re-evaluation of the threshold exposure level of inhaled JP-8 in mice. The Journal of Toxicological Sciences 31(3), 219—28.
14. Keil, D., Dudley, A., EuDaly, J., Dempsey, J., Butterworth, L., Gilkeson, G. and Peden-Adams, M. 2004: Immunological and hematological effects observed in B6C3F1 mice exposed to JP-8 jet fuel for 14 days. Journal of Toxicology and Environmental Health Part A 67(14), 1109—29.
15. Li, T.K. and Fox, B.S. 1993: Effect of prostaglandin E2 (PGE2) on IL-3/granulocyte-macrophage colony-stimulating factor production by T helper cells. Mode of stimulation and presence of costimulation can determine response to PGE2. Journal of Immunology 150(5), 1680—90.
16. Mattie, D.R., Alden, C.L., Newell, T.K., Gaworski, C.L. and Flemming, C.D. 1991: A 90-day continuous vapor inhalation toxicity study of JP-8 jet fuel followed by 20 or 21 months of recovery in Fischer 344 rats and C56BL/6 mice. Toxicology and Pathology 19(2), 77—87.
17. Mattie, D.R., Marit, G.B., Flemming, C.D. and Cooper, J.R. 1995: The effects of JP-8 jet fuel on male Sprague-Dawley rats after a 90-day exposure by oral gavage. Toxicology and Industrial Health 11, 423—35.
18. Mosmann, T.R. and Moore, K.W. 1991: The role of IL-10 in cross regulation of TH1 and TH2 responses. Immunology Today 12(3), A49—53.
19. O'Garra, A., Chang, R., Go, N., Hastings, R., Haughton, G. and Howard, M. 1992: Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. European Journal of Immunology 22(3), 711—17.
20. Ohnishi, H., Lin, T.H., Nakajima I. and Chu, T.M. 1991: Prostaglandin E2 from macrophages of murine splenocyte cultures inhibits the generation of lymphokine-activated killer cell activity. Tumour Biology 12(2), 99—110.
21. Pfaff, J., Parliman, G., Parton, K., Lantz, R., Chen, H., Hays, A. and Witten, M. 1993: Pathologic changes after JP-8 jet fuel inhalation in Fischer 344 rats. The FASEB Journal 7, A408.
22. Pfaff, J., Parton, K., Lantz, R.C., Chen, H., Hays, A. and Witten, M.L. 1995: Inhalation exposure to JP-8 jet fuel alters pulmonary function and substance P levels in Fischer 344 rats. Journal of Applied Toxicology 15(4), 249—56.
23. Ramos, G., Nghiem, D.X., Wlaterscheid, J.P. and Ullrich, S.E. 2002: Dermal application of jet fuel suppresses secondary immune reactions. Toxicology and Applied Pharmacology 180(2), 136—44.
24. Ramos, G., Kazimi, N., Nghiem, D.X., Walterscheid, J.P. and Ullrich, S.E. 2004: Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. Toxicology and Applied Pharmacology 195(3), 331—38.
25. Sica, A., Saccani, A., Bottazzi, B., Polentarutti, N., Vecchi, A., Damme, J.V. and Mantovani, A. 2000: Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages. Journal Immunology 164, 762—67.
26. Struwe, G., Knave, B. and Mindus, P. 1983: Neuropsychiatric symptoms in workers occupationally exposed to jet fuel-a combined epidemiologic and causistic study. Acta Psychiatrica Scandinavica 303(S), 55—67.
27. Ullrich, S.E. 1999: Dermal application of JP-8 jet fuel induces immune suppression. Toxicological Sciences 52, 61—67.
28. Ullrich, S.E. and Lyons, H.J. 2000: Mechanisms involved in the immunotoxicity induced by dermal application of JP-8 jet fuel. Society of Toxicology 58, 290—98.
29. Witten, M.L., Leeman, S.E., Lantz, R.C., Joseph, P.M., Burke, C.H., Jung, W.K., Quinn, D. and Hales, C.A. 1990: Chronic jet fuel exposure increases lung substance P (SP) concentration in rabbits. In S.E. Leeman, editor, Substance P and related peptides: cellular and molecular physiology. International Symposium, University of Massachusetts and the New York Academy of Science, New York, 29.
30. Witten, M.L., Pfaff, J., Lantz, R.C., Parton, K.H., Chen, H., Hays, A. and Leeman, S.E. 1992: Capsaicin pretreatment before JP-8 jet fuel exposure causes a large increase in airway sensitivity to histamine in rats. Regulatory Peptide S1, S176.