Levamisole enhances immune response by affecting the activation and maturation of human monocyte-derived dendritic cells

Clinical and Experimental Immunology

Volumn 151, Issue 1, 2008, Pages 174-181

  Chen, L Y ^a   Lin, Y L ^a   Chiang, B L ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Dendritic cells; Levamisole; Signal transduction; T cells; Th1 Th2 cells

Indexed keywords

B7 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; LEVAMISOLE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P40; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2;

ARTICLE; CELL MATURATION; CELL MEMBRANE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG MECHANISM; HELPER CELL; HUMAN; HUMAN CELL; MOLECULE; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTHELMINTICS; CELLS, CULTURED; DENDRITIC CELLS; FLOW CYTOMETRY; HLA-DR ANTIGENS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12 SUBUNIT P40; LEVAMISOLE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MAP KINASE SIGNALING SYSTEM; STIMULATION, CHEMICAL; TH1 CELLS; TOLL-LIKE RECEPTOR 2;

EID: 36849046320     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03541.x     Document Type: Article

References (34)

1. Thienpont D, Vanparijs OF, Raeymaekers AH et al. Tetramisole (R 8299), a new, potent broad spectrum antihelmintic. Nature 1996 209 : 1084 6.
2. Katoch K. Immunotherapy of leprosy. Indian J Lepr 1996 68 : 349 61.
3. Schiller JH, Lindstrom M, Witt PL et al. Immunological effects of levamisole in vitro. J Immunother 1991 10 : 297 306.
4. Mutch RS, Hutson PR. Levamisole in the adjuvant treatment of colon cancer. Clin Pharm 1991 10 : 95 109.
5. Szeto C, Gillespie KM, Mathieson PW. Levamisole induces interleukin-18 and shifts type 1/type 2 cytokine balance. Immunology 2000 100 : 217 24.
6. Kocabas CN, Sekerel BE, Firat PA, Okur H, Adahoglu G. Levamisole: might it be used in treatment and prevention of atopic diseases? J Asthma 2004 41 : 547 51.
7. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 52.
8. Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 1997 388 : 782 7.
9. Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997 9 : 10 16.
10. Reis e Sousa. Dendritic cells in a mature age. Nat Rev Immunol 2006 6 : 476 83.
11. Zhou LJ, Tedder TF. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci USA 1996 93 : 2588 92.
12. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994 179 : 1109 18.
13. Lin YL, Liang YC, Lee SS, Chiang BL. Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways. J Leukoc Biol 2005 78 : 533 43.
14. Moore KW, de Waal MR, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001 19 : 683 765.
15. O'Sullivan BJ, Thomas R. CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappaB. J Immunol 2002 168 : 5491 8.
16. Yoshimoto T, Kojima K, Funakoshi T et al. Molecular cloning and characterization of murine IL-12 genes. J Immunol 1996 156 : 1082 8.
17. Kobayashi M, Fitz L, Ryan M et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989 170 : 827 45.
18. Daftarian PM, Kumar A, Kryworuchko M, Diaz-Mitoma F. IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha. J Immunol 1996 157 : 12 20.
19. Willems F, Marchant A, Delville JP et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994 24 : 1007 9.
20. Ding L, Shevach EM. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol 1992 148 : 3133 9.
21. Adler AJ, Marsh DW, Yochum GS et al. CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J Exp Med 1998 187 : 1555 64.
22. Kalinski P, Hilkens CM, Wierenga EA, Kapsenberg ML. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 1999 20 : 561 7.
23. Redecke V, Hacker H, Datta SK et al. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 2004 172 : 2739 43.
24. Jotwani R, Pulendran B, Agrawal S, Cutler CW. Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro. Eur J Immunol 2003 33 : 2980 6.
25. Agrawal S, Agrawal A, Doughty B et al. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen- activated protein kinase and c-Fos. J Immunol 2003 171 : 4984 9.
26. Eisenbarth SC, Piggott DA, Huleatt JW et al. Lipopolysaccharide-enhanced, Toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002 196 : 1645 51.
27. Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007 7 : 179 90.
28. Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 2005 6 : 769 76.
29. Gautier G, Humbert M, Deauvieau F et al. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med 2005 201 : 1435 46.
30. Re F, Strominger JL. IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells. J Immunol 2004 173 : 7548 55.
31. Trailovic SM, Robertson AP, Clark CL, Martin RJ. Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest that CaM kinase and tyrosine kinase regulate sensitivity to levamisole. J Exp Biol 2002 205 : 3979 88.
32. Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998 16 : 225 60.
33. Kube D, von Platzer C, KA et al. Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines. Cytokine 1995 7 : 1 7.
34. Foey AD, Parry SL, Williams LM et al. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol 1998 160 : 920 8.