Synthesis and primary evaluation of novel HIV-1 inhibitors

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 8-9, 2007, Pages 1161-1165

  Safadi, Yazan El ^a   Marquet, Roland ^a   Aubertin, Anne Marie ^b   Vivet Boudou, Valérie ^a  

^a INST DE BIOL MOLEC ET CELLULAIRE   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Antiviral drug resistance; HIV 1; Viral error catastrophe

Indexed keywords

8 AMIDO 2' DEOXYADENOSINE; ANTIVIRUS AGENT; DEOXYADENOSINE DERIVATIVE; NUCLEOSIDE; NUCLEOSIDE DERIVATIVE; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS DNA;

ARTICLE; BROMINATION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; VIRUS INHIBITION; VIRUS RESISTANCE; VIRUS VIABILITY;

ANTI-HIV AGENTS; DEOXYADENOSINES; DRUG DESIGN; DRUG RESISTANCE, VIRAL; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 36849044083     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701527109     Document Type: Article

References (6)

1. Anderson, J.P.; Daifuku, R.; Loeb, L.A. Viral error catastrophe by mutagenic nucleosides. Annu. Rev. Microbiol. 2004, 58, 183-205.
2. Smith, R.A.; Loeb, L.A.; Preston, B.D. Lethal mutagenesis of HIV. Virus Research 2005, 107, 215-228.
3. Harris, K.S.; Brabant, W.; Styrchak, S.; Gall, A.; Daifuku, R. KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral Research 2005, 67, 1-9.
4. Crotty, S.; Maag, D.; Arnold, J.J.; Zhong, W.; Lau, J.Y.N.; Hong, Z.; Andino, R.; Cameron, C.E. The broad spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 2000, 12(6), 1375-1379.
5. Matsuda, A.; Nomoto, Y.; Ueda, T. Synthesis of 2- and 8-cyanoadenosine and their derivatives. Chem. Pharm. Bull. 1978, 27(1), 183-192.
6. Gaied, N.B.; Glasser, N.; Ramalanjaona, N.; Beltz, H.;Wolf, P.;Marquet, R.; Burger, A.; Mely, Y. 8-vinyldeoxyadenosine, an alternative analog to 2′-deoxyribosyl-2-aminopurine with improved properties. Nucleic Acids Research 2005, 33(3), 1031-1039.