Pyroglutamic acidemia associated with acetaminophen;Acidosis piroglutámica asociada a paracetamol

Anales de Pediatria

Volumn 67, Issue 6, 2007, Pages 582-584

  Alados Arboledas, F J ^a,d   De La Oliva Senovilla, P ^b   Garcia Munoz Ma J ^c   Alonso Melgar, A ^b   Ruza Tarrio F ^b  

^a Unidad de Cuidados Paliativos   (Spain)

^b HOSPITAL INFANTIL LA PAZ   (Spain)

^c Facultad de Ciencias   (Spain)

^d NONE   (Spain)

Author keywords

5 oxoprolinemia; Acetaminophen; Hemolytic uremic syndrome; High anion gap metabolic acidosis; Pyroglutamic acidemia

Indexed keywords

AMINO ACID; CREATININE; PARACETAMOL; PYROGLUTAMIC ACID;

ACIDEMIA; ANION GAP; ARTICLE; CASE REPORT; CHILD; CREATININE BLOOD LEVEL; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; HEMOLYTIC UREMIC SYNDROME; HUMAN; LACTIC ACIDOSIS; MALE; METABOLIC ACIDOSIS; PLASMA OSMOLARITY; PROTEIN BLOOD LEVEL; SEPTIC SHOCK;

EID: 36849043986     PISSN: 16954033     EISSN: 16959531     Source Type: Journal    
DOI: 10.1157/13113021     Document Type: Article

References (8)

1. Granry JC, Rod B, Monrigal JP, Merck J, Berniere J, Jean N, et al. The analgesic efficacy of an injectable prodrug of acetaminophen in children after orthopaedic surgery. Paediatr Anaesth. 1997;7:445-9.
2. Potter DW, Hinson JA. Reactions of N-acetyl-p-benzoquinone imine with reduced glutathione, acetaminophen, and NADPH. Mol Pharmacol. 1986;30:33-41.
3. Dempsey GA, Lyall HJ, Corke CF, Scheinkestel CD. Pyroglutamic acidemia: A cause of high anion gap metabolic acidosis. Crit Care Med. 2000;28:1803-7.
4. Creer MH, Lau B, Jones JD, Chan KM. Pyroglutamic acidemia in an adult patient. Clin Chem. 1989;35:684-6.
5. Pitt JJ. Association between paracetamol and pyroglutamic aciduria. Clin Chem. 1990;36:173-4.
6. Pitt JJ, Hauser S. Transient 5-oxoprolinuria and high anion gap metabolic acidosis: Clinical and biochemical findings in eleven subjects. Clin Chem. 1998;44:1497-503.
7. Humphreys BD, Forman JP, Zandi-Nejad K, Bazari H, Seifter J, Magee CC. Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital. Am J Kidney Dis. 2005;46:143-6.
8. Persaud C, Forrester T, Jackson AA. Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine. J Nutr. 1996;126:2823-30.