Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital

American Journal of Kidney Diseases

Volumn 46, Issue 1, 2005, Pages 143-146

  Humphreys, Benjamin D ^a   Forman, John P ^b   Zandi Nejad, Kambiz ^b   Bazari, Hasan ^b   Seifter, Julian ^b   Magee, Colm C ^b  

^a HARVARD INSTITUTES OF MEDICINE   (United States)

^b NONE

Author keywords

5 oxoprolinuria; Acetaminophen; Anion gap; Glutathione; Metabolic acidosis; Pyroglutamic aciduria

Indexed keywords

ACETYLCYSTEINE; CARBOXYLIC ACID; PARACETAMOL; PYROGLUTAMIC ACID;

ADULT; ANION GAP; ARTICLE; CASE REPORT; CHEMOTHERAPY; FEVER; HOSPITAL; HUMAN; HYPERPROLINEMIA; KIDNEY DYSFUNCTION; LYMPHOMA; MALE; MENTAL HEALTH; METABOLIC ACIDOSIS; NEUTROPENIA; PYROGLUTAMIC ACIDURIA; SALVAGE THERAPY; SCREENING; SEPSIS; URINALYSIS;

ACETAMINOPHEN; ACID-BASE EQUILIBRIUM; ACIDOSIS; ADULT; ANALGESICS, NON-NARCOTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BICARBONATES; CANDIDIASIS; CHLORIDES; CYTARABINE; ETOPOSIDE; FATAL OUTCOME; FEVER; HUMANS; IFOSFAMIDE; KIDNEY TUBULAR NECROSIS, ACUTE; LYMPHOMA, FOLLICULAR; LYMPHOMA, LARGE-CELL; MALE; MESNA; NEUTROPENIA; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PYRROLIDONECARBOXYLIC ACID; SALVAGE THERAPY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 20544432919     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2005.04.010     Document Type: Article

References (15)

1. E. Jellum, T. Kluge, H.C. Borresen, O. Stokke, L. Eldjarn Pyroglutamic aciduria - A new inborn error of metabolism Scand J Clin Lab Invest 26 1970 327 335
2. E. Mayatepek 5-Oxoprolinuria in patients with and without defects in the gamma-glutamyl cycle Eur J Pediatr 158 1999 221 225
3. M.H. Creer, B.W. Lau, J.D. Jones, K.M. Chan Pyroglutamic acidemia in an adult patient Clin Chem 35 1989 684 686
4. J.J. Pitt, S. Hauser Transient 5-oxoprolinuria and high anion gap metabolic acidosis Clinical and biochemical findings in eleven subjects Clin Chem 44 1998 1497 1503
5. G.A. Dempsey, H.J. Lyall, C.F. Corke, C.D. Scheinkestel Pyroglutamic acidemia A cause of high anion gap metabolic acidosis Crit Care Med 28 2000 1803 1807
6. J.R. Bonham, J.M. Rattenbury, A. Meeks, R.J. Pollitt Pyroglutamicaciduria from vigabatrin Lancet 1 1989 1452 1453
7. B.L. Croal, A.C. Glen, C.J. Kelly, R.W. Logan Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy Clin Chem 44 1998 336 340
8. J.J. Pitt, G.K. Brown, V. Clift, J. Christodoulou Atypical pyroglutamic aciduria Possible role of paracetamol J Inherit Metab Dis 13 1990 755 756
9. B.A. Mizock, S. Belyaev, C. Mecher Unexplained metabolic acidosis in critically ill patients The role of pyroglutamic acid Intensive Care Med 30 2004 502 505
10. A. Jain, N.R. Buist, N.G. Kennaway, B.R. Powell, P.A. Auld, J. Martensson Effect of ascorbate or N-acetylcysteine treatment in a patient with hereditary glutathione synthetase deficiency J Pediatr 124 1994 229 233
11. J. Martensson, J. Gustafsson, A. Larsson A therapeutic trial with N-acetylcysteine in subjects with hereditary glutathione synthetase deficiency (5-oxoprolinuria) J Inherit Metab Dis 12 1989 120 130
12. S.H. Yale, J.J. Mazza Anion gap acidosis associated with acetaminophen Ann Intern Med 133 2000 752 753
13. N. Dahl, M. Pigg, E. Ristoff Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction Hum Mol Genet 6 1997 1147 1152
14. Z.Z. Shi, G.M. Habib, W.J. Rhead Mutations in the glutathione synthetase gene cause 5-oxoprolinuria Nat Genet 14 1996 361 365
15. A. Larsson, B. Mattsson, E.A. Wauters, J.D. van Gool, M. Duran, S.K. Wadman 5-Oxoprolinuria due to hereditary 5-oxoprolinase deficiency in two brothers - A new inborn error of the gamma-glutamyl cycle Acta Paediatr Scand 70 1981 301 308