The analgesic efficacy of an injectable prodrug of acetaminophen in children after orthopaedic surgery

Paediatric Anaesthesia

Volumn 7, Issue 6, 1997, Pages 445-449

  Granry, J C ^a   Rod, B ^a   Monrigal, J P ^a   Merckx, J ^b   Berniere, J ^c   Jean, N ^d   Boccard, E ^e  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c ARMAND TROUSSEAU HOSPITAL   (France)

^d RAYMOND POINCARÉ HOSPITAL   (France)

^e UPSA   (France)

Author keywords

Paracetamol; Postoperative pain; Prodrug; Propacetamol

Indexed keywords

FENTANYL; MIDAZOLAM; PARACETAMOL; PRODRUG; PROPACETAMOL; THIOPENTAL; VECURONIUM;

ADOLESCENT; ANALGESIC ACTIVITY; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORTHOPEDIC SURGERY; PAIN ASSESSMENT; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; VOMITING;

EID: 0030720970     PISSN: 11555645     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9592.1997.d01-121.x     Document Type: Article

References (17)

1. Rumack B.H. Aspirin versus Acetaminophen: a comparative view. Pediatrics, 1978; 62: 943-946.
2. Shannon M, Berde C.B. Acute pain in children. Pharmacologic management of pain in children and adolescents. Pediatr Clin N Am, 1989; 36: 855-871.
3. Van Acken H, Gerin M, Thijs J. et al. Comparative analgesic efficacy of repeated dosing of propacetamol and morphine on postoperative pain after oral surgery. VIII World Congress on Pain, Vancouver, 1996; 265.
4. Hynes D, McCarroll M, Gerin M, et al. Propacetamol vs diclofenac and placebo for postoperative pain control after hip arthroplasty. VIII World Congress on Pain, Vancouver, 1996; 266.
5. Bannwarth B, Netter P, Lapicque F, et al. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br J Clin Pharmac 1992; 34: 79-81.
6. Piletta P, Porchet H.C., Dayer P. Central analgesic effect of acetaminophen but not of aspirin. Clin Pharmacol Ther 1991; 4: 350-354.
7. Depre M, Van Hecken A, Verbesselt R, et al. Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use. Fundam Clin Pharmacol 1992; 6: 259-262.
8. Luthy C.S. Collart L., Dayer P. Administration profile controls Acetaminophen analgesia. Clin Pharmacol Ther 1993; 2: 171-173.
9. Maunuksela E.L., Olkkola K.T., Korpela R. Measurement of pain in children with self-reporting and behavioural assessment. Clin Pharm Ther 1987; 42: 137-141.
10. Skoglund L.A., Skjelbred P., Fyllingen G. Analgesic efficacy of acetaminophen 1000 mg, acetaminophen 2000 mg, and the combination of acetaminophen 1000 mg and codeine phosphate 60 mg versus placebo in acute postoperative pain. Pharmacotherapy 1991; 11: 364-369.
11. Piguet V, Desmeules J., Collart L. et al. Lack of acetaminophen ceiling effect on RIII nociceptive flexion reflex. Clin Pharm Ther 1994; 55: 124.
12. Delbos A, Boccard E. The morphine-sparing effect of propacetamol in orthopedic postoperative pain. J Pain Sympt Man 1995; 10: 279-286.
13. Granry J.C., Rod B., Boccard E. et al. Pharmacokinetics and antipyretic effects of an injectable pro-drug of paracetamol (propacetamol) in children. Paediatr Anaesth 1992; 2: 291-295.
14. Autret E, Dutertre J.P., Breteau M. et al. Pharmacokinetics of paracetamol in the neonate and infant after administration of propacetamol hydrochloride. Dev Pharmacol Ther 1993; 20: 129-134.
15. Moore P.A., Acs G., Hargreaves J.A. Post-extraction pain relief in children: a clinical trial of liquid analgesics. Int J Clin Pharmacol 1985; 23: 573-576.
16. Temple A.R. Pediatric dosing of acetaminophen. Pediatr Pharmacol 1983; 3: 321-327.
17. Rod B., Monrigal J.P., Lepoittevin L. et al. Traitement de la douleur postopératoire chez l'enfant en salle de réveil: utilisation de la morphine et du propacétamol par voie intraveineuse. Cah d'Anesthés, 1989; 37: 525-530.