Characterisation, dissemination and persistence of gentamicin resistant Escherichia coli from a Danish university hospital to the waste water environment

Environment International

Volumn 34, Issue 1, 2008, Pages 108-115

  Jakobsen, Lotte ^a   Sandvang, Dorthe ^a   Hansen, Lars H ^b   Bagger Skjøt, Line ^a   Westh, Henrik ^c   Jørgensen, Claus ^e   Hansen, Dennis S ^c,d   Pedersen, Bodil M ^e   Monnet, Dominique L ^a   Frimodt Møller, Niels ^a   Sørensen, Søren J ^b   Hammerum, Anette M ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c HVIDOVRE HOSPITAL   (Denmark)

^d HILLERØD HOSPITAL   (Denmark)

^e DHI   (Denmark)

Author keywords

Antimicrobial resistance; Dissemination; Escherichia coli; Gentamicin; Virulence

Indexed keywords

GENES; HOSPITALS; WASTEWATER; WASTEWATER TREATMENT;

ANTIMICROBIAL RESISTANCE; GENTAMICIN; PHENOTYPIC RESISTANCE PATTERN; PULSED FIELD GEL ELECTROPHORESIS (PFGE);

ESCHERICHIA COLI;

AMPICILLIN; CYTOTOXIC NECROTIZING FACTOR 1; GENTAMICIN; NALIDIXIC ACID; STREPTOMYCIN; SULFAMETHOXAZOLE; TETRACYCLINE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BACTERIUM; HOSPITAL SECTOR; PERSISTENCE; RESIDENTIAL LOCATION; VIRULENCE; WASTEWATER; WATER TREATMENT;

AAC3 1 GENE; AAC3 2 GENE; AAC3 3 GENE; AAC3 4 GENE; ANT 2' 1 GENE; ANTIBIOTIC RESISTANCE; ARMA GENE; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM DETECTION; BACTERIUM ISOLATION; CHUA GENE; COLIFORM BACTERIUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ESCHERICHIA COLI; FOGG GENE; FYUA GENE; GENE IDENTIFICATION; HLYA GENE; HUMAN; IRON GENE; IUTA GENE; MALX GENE; NONHUMAN; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SFAS GENE; TRAT GENE; UNIVERSITY HOSPITAL; URINARY TRACT INFECTION; WASTE WATER MANAGEMENT; WASTE WATER TREATMENT PLANT; WATER SAMPLING;

ARMA; ESCHERICHIA COLI;

EID: 36849040053     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2007.07.011     Document Type: Article

References (31)

1. Anonymous. DANMAP 2003. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark, 1600-2032 (2004)
2. Anonymous. DANMAP 2005. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark, 1600-2032 (2006)
3. Blattner F.R., Plunkett III G., Bloch C.A., Perna N.T., Burland V., Riley M., et al. The complete genome sequence of Escherichia coli K-12. Science 277 (1997) 1453-1474
4. Blum G., Falbo V., Caprioli A., and Hacker J. Gene clusters encoding the cytotoxic necrotizing factor type 1, Prs-fimbriae and [alpha]-hemolysin form the pathogenicity island II of the uropathogenic Escherichia coli strain J96. FEMS Microbiol Lett 126 (1995) 189-195
5. Chaslus-Dancla E., Glupcznski Y., Gerbaud G., Lagorce M., Lafont J.P., and Courvalin P. Detection of apramycin resistant Enterobactericeae in hospital isolates. FEMS Microbiol Lett 52 (1989) 261-265
6. Danish Medicines Agency. Antibiotika månedstabeller 1-12-2003. http:// www.produktresume.dk/docushare/dscgi/admin.py/View/Collection-152 (Accessed 1.december 2003).
7. Ejrnaes K., Sandvang D., Lundgren B., Ferry S., Holm S., Monsen T., et al. Pulsed-field gel electrophoresis typing of Escherichia coli strains from samples collected before and after pivmecillinam or placebo treatment of uncomplicated community-acquired urinary tract infection in women. J Clin Microbiol 44 (2006) 1776-1781
8. Fontaine III T.D., and Hoadley A.W. Transferable drug resistance associated with coliforms isolated from hospital and domestic sewage. Health Lab Sci 13 (1975) 238-245
9. Galimand M., Sabtcheva S., Courvalin P., and Lambert T. Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Antimicrob Agents Chemother 49 (2005) 2949-2953
10. Galimand M., Courvalin P., and Lambert T. Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation. Antimicrob Agents Chemother 47 (2003) 2565-2571
11. Gonzalo M.P., Arribas R.M., Latorre E., Baquero F., and Matinez J.L. Sewage dilution and loss of antibiotic resistance and virulence determinants in E. coli. FEMS Microbiol Lett 59 (1989) 93-96
12. Gonzalo M.P., Martinez J.L., Baquero F., Gomez-Lus R., and Perez-Diaz J.C. Aerobactin production linked to transferable antibiotic resistance in Escherichia coli strains isolated from sewage. FEMS Microbiol Lett 50 (1988) 57-59
13. Guardabassi L., Lo Fo Wong D.M.A., and Dalsgaard A. The effects of tertiary wastewater treatment on the prevalence of antimicrobial resistant bacteria. Water Res 36 (2002) 1955-1964
14. Hacker J. Role of fimbrial adhesins in the pathogenesis of Escherichia coli infections. Can J Microbiol 38 (1992) 720-727
15. Hacker J., and Kaper J.B. Pathogenecity islands and the evolution of microbes. Annu Rev Microbiol 54 (2002) 641-679
16. Hamelin K., Bruant G., El Shaarawi A., Hill S., Edge T.A., Bekal S., et al. A virulence and antimicrobial resistance DNA microarray detects a high frequency of virulence genes in Escherichia coli isolates from Great Lakes recreational waters. Appl Environ Microbiol 72 (2006) 4200-4206
17. Hamelin K., Bruant G., El Shaarawi A., Hill S., Edge T.A., Fairbrother J., et al. Occurrence of virulence and antimicrobial resistance genes in Escherichia coli isolates from different aquatic ecosystems within the St. Clair River and Detroit River areas. Appl Environ Microbiol 73 (2007) 477-484
18. Heuer H., Krögerrechklenfort E., Wellington E.M.H., Egan S., van Elsas J.D., van Overbeek L., et al. Gentamicin resistance genes in environmental bacteria: prevalence and transfer. FEMS Microbiol Ecol 42 (2002) 289-302
19. Jensen V.F., Jakobsen L., Emborg H.D., Seyfarth A.M., and Hammerum A.M. Correlation between apramycin and gentamicin in pigs and an increasing reservoir of gentamicin-resistant Escherichia coli. J Antimicrob Chemother 58 (2006) 101-107
20. Johnson J.R. Virulence factors in Escherichia coli urinary tract infections. Clin Microbiol Rev 4 (1991) 80-128
21. Kralikova K., Krcméry Sr. V., and Krcméry Jr. V. Incidence of gentamicin resistant bacteria and those with R plasmids, transferable to E. coli K-12, in Municipal Waste Waters. Recomb DNA Tech Bull 6 (1983) 98-100
22. Kummerer K., and Henninger A. Promoting resistance by the emission of antibiotics from hospitals and households into effluent. Clin Microbiol Infect 9 (2003) 1203-1214
23. Miller G.H., Sabatelli F.J., Naples L., Hare R.S., and Shaw K.J. The most frequently occurring aminoglycoside resistance mechanisms-combined results of surveys in eight regions of the world. The aminoglycoside resistance study groups. J Chemother 7 (1995) 17-30
24. NCCLS. Performance standards for antimicrobial susceptibility testing; 12th informational supplement M7-A6 (2003), NCCLS, Villanova, PA, USA
25. Pedersen B.M., Nielsen U., Jørgensen C., Hammerum A.M., and Monnet D.L. Måleprogram- antibiotikaresistens i spildevand fra et sygehus og et boligområde (Report from Lynettefællesskabets Miljøgruppe and Statens Serum Institut) (2004)
26. Sandvang D., and Aarestrup F.M. Characterization of aminoglycoside resistance genes and class 1 integrons in porcine and bovine gentamicin-resistant Escherichia coli. Microb Drug Resist 6 (2000) 19-27
27. Schønheyder H.C., and Højbjerg T. The impact of the first notification of positive blood cultures on antibiotic therapy. APMIS 103 (1995) 37-44
28. Schønheyder H.C., Sanden A., and Sorensen H. The prevalence of gentamicin resistance among clinical isolates of enterobacteria in a Danish region. APMIS 108 (2000) 145-152
29. Schubert S., Rakin A., Karch H., Carniel E., and Heesemann J. Prevalence of the "high-pathogenicity island" of yersinia species among Escherichia coli strains that are pathogenic to humans. Infect Immun 66 (1998) 480-485
30. Sturtevant A.B.J., and Feary T.W. Incidence of infectious drug resistance among lactose-fermenting bacteria isolated from raw and treated sewage. Appl Microbiol 18 (1969) 918-924
31. WHO, Collaborating centre for drug statistics methodology. ATC/DDD Index 2003. 1-12-2003, http://www.whocc.no/atcddd/ (Accessed 1. December 2003).