Influence of solid lipid microparticle carriers on skin penetration of the sunscreen agent, 4-methylbenzylidene camphor

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 12, 2007, Pages 1621-1627

  Scalia, Santo ^a,c   Mezzena, Matteo ^a   Iannuccelli, Valentina ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c Dipartimento di Scienze Farmaceutiche   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLBENZYLIDENE CAMPHOR; CELLULOSE ACETATE; DRUG CARRIER; LIPID; SUNSCREEN; TRISTEARIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DIFFUSION; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; EMULSION; FEMALE; HUMAN; HUMAN EXPERIMENT; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPE; SKIN PENETRATION;

ADMINISTRATION, CUTANEOUS; ADULT; CAMPHOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; EMULSIONS; FEMALE; HUMANS; LIPIDS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; OINTMENTS; PARTICLE SIZE; SKIN; SKIN ABSORPTION; SUNSCREENING AGENTS; THERMOGRAPHY;

EID: 36849023820     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.12.0003     Document Type: Article

References (28)

1. Bonda, C. A. (2005) The photostability of organic sunscreen actives: a review. In: Shaath, N. (ed.) Sunscreens. Taylor Francis Group, Boca Raton, FL, pp 342-343
2. Chatelain, E., Gabard, B., Surber, C. (2003) Skin penetration and sun protection factor of five UV filters: effect of the vehicle. Skin Pharmacol. Appl. Skin Physiol. 16: 28-35
3. COLIPA - The European Cosmetic, Toiletry and Perfumery Association (1994) Sun protection factor test method, Brussels
4. Diffey, B. L., Robson, J. (1989) A new substrate to measure sunscreen protection factors throughout the ultraviolet spectrum. J. Soc. Cosmet. Chem. 40: 127-133
5. EC Commission Recommendation (2006) On the efficacy of sunscreen products and the claims made relating thereto, Official Journal of the European Union, L 265, pp 39-43
6. Gasparro, F. P., Mitchnick, M., Nash, J. F. (1998) A review of sunscreen safety and efficacy. Photochem. Photobiol. 68: 243-256
7. Green, A., Williams, G., Neale, R., Hart, V., Leslie, D., Parsons, P., Marks, G. C., Gaffney, P., Battistutta, D., Frost, C., Lang, C., Russell, A. (1999) Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet 354: 723-729
8. Iannuccelli, V., Sala, N., Tursilli, R., Coppi, G., Scalia, S. (2006) Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostability. Eur. J. Pharm. Biopharm. 63: 140-145
9. Janjua, N. R., Mogensen, B., Andersson, A., Petersen, J. H., Henriksen, M., Skakkebaek, N. E., Wulf, H. C. (2004) Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycin-namate, and 3-(4-methyl-benzylidene)camphor after whole-body topical application and reproductive hormone levels in humans. J. Invest. Dermatol. 123: 57-61
10. Jaspart, S., Piel, G., Delattre, L., Evrard, B. (2005) Solid lipid microparticles: formulation, preparation, characterization, drug release and applications. Expert Opin. Drug. Deliv. 2: 75-87
11. Klein, K., Palefsky, I. (2005) Formulating sunscreen products. In: Shaath, N. (ed.) Sunscreens. Taylor Francis Group, Boca Raton, FL, pp 356-362
12. Müller, R. H., Radtke, M., Wissing, S. A. (2002) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54: S131-S155
13. Nohynek, G. J., Schaefer, H. (2001) Benefit and risk of organic filters. Regul. Toxicol. Pharmacol. 33: 285-299
14. Scalia, S., Simeoni, S., Barbieri, A., Sostero, S. (2002) Influence of hydroxypropyl-β-cyclodextrin on photo-induced free radical production by the sunscreen agent, butyl-methoxydibenzoylmethane. J. Pharm. Pharmacol. 54: 1553-1558
15. Scalia, S., Tursilli, R., Iannuccelli, V. (2007) Complexation of the sunscreen agent, 4-methylbenzylidene camphor with cyclodextrins: effect on photostability and human stratum corneum penetration. J. Pharm. Biomed. Anal. 44: 29-34
16. Schauer, U. M. D., Völkel, W., Heusener, A., Colnot, T., Broschard, T. H., von Landenberg, F., Dekant, W. (2006) Kinetics of 3-(4-methylbenzylidene) camphor in rats and humans after dermal application. Toxicol. Appl. Pharmacol. 216: 339-346
17. Schlossman, D., Shao, Y. (2005) Inorganic ultraviolet filters. In: Shaath, N. (ed.) Sunscreens. Taylor Francis Group, Boca Raton, FL, pp 246-260
18. Schlumpf, M., Schmid, P., Durrer, S., Conscience, M., Maerkel, K., Henseler, M., Gruetter, M., Herzog, I., Reolon, S., Ceccatelli, R., Faass, O., Stutz, E., Jarry, H., Wuttke, W., Lichtensteiger, W. (2004) Endocrine activity and developmental toxicity of cosmetic UV filters - An update. Toxicology 205: 113-122
19. Shah, V. P., Flynn, G. L., Yacobi, A., Maibach, H. I., Bon, C., Fleischer, N. M., Franz, T. J., Kaplan, S. A., Kawamoto, J., Lesko, L. J., Marty, J. P., Pershing, L. K., Schaefer, H., Sequeira, J. A., Shrivastava, S. P., Wilkin, J., Williams, R. L. (1998) AAPS/FDA Workshop Report - Bioequivalence of topical dermatological dosage forms - methods of evaluation of bioequivalence. Pharm. Res. 15: 167-171
20. Steinberg, D. C. (2005) Regulations of sunscreens worldwide. In: Shaath, N. (ed.) Sunscreens. Taylor Francis Group, Boca Raton, FL, pp 180-181
21. Tarras-Wahlberg, N., Stenhagen, G., Larkö, O., Rosén, A., Wennberg, A. M., Wennerström, O. (1999) Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation. J. Invest. Dermatol. 113: 547-553
22. Toll, R., Jacobi, U., Richter, H., Lademann, J., Schaefer, H., Blume-Peytavi, U. (2004) Penetration profile of microspheres in follicular targeting of terminal hair follicles. J. Invest. Dermatol. 121: 68-176
23. Treffel, P., Gabard, B. (1996) Skin penetration and sun protection factor of ultra-violet filters from two vehicles. Pharm. Res. 13: 770-774
24. Tursilli, R. Piel, G., Delattre, L., Scalia, S. (2007) Solid lipid microparticles containing the sunscreen agent, octyl-dimethylaminobenzoate: effect of the vehicle. Eur. J. Pharm. Biopharm. 66: 483-487
25. Weigmann, H.-J., Jacobi, U., Antoniou, C., Tsikrikas, G. N., Wendel, V., Rapp, C., Gers-Barlag, H., Sterry, W., Lademann, J. (2005) Determination of penetration profiles of topically applied substances by means of tape stripping and optical spectroscopy: UV filter substance in sunscreens. J. Biomed. Opt. 10: 1-7
26. Wiechers, J. W. (2000) Avoiding transdermal cosmetic delivery. Cosmet. Toil. 115: 39-46
27. Wissing, S. A., Müller, R. H. (2002) Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration. J. Control. Release 81: 225-233
28. Yener, G., Incegül, T., Yener, N. (2003) Importance of using solid lipid microspheres as carriers for UV filters on the example of octyl methoxy cinnamate. Int. J. Pharm. 258: 203-207