Palladium-catalyzed synthesis of spiro[2.4]heptanes: Ligand-dependent position control in the nucleophilic attack to a π-allylpalladium intermediate

Journal of the American Chemical Society

Volumn 129, Issue 48, 2007, Pages 14866-14867

  Shintani, Ryo ^a   Park, Soyoung ^a   Hayashi, Tamio ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPTANE DERIVATIVE; PALLADIUM; SPIRO[2.4]HEPTANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLOADDITION; CYCLOPROPANATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SUBSTITUTION REACTION; SYNTHESIS;

EID: 36849007542     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja077236o     Document Type: Article

References (39)

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39. As kindly suggested by one of the reviewers, the observed selectivity may be explained by the steric demand of palladacyclobutane intermediate C (Figure 2), the formation of which becomes unfavorable upon using a bulky phosphine ligand.