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Volumn 44, Issue 1, 2007, Pages 49-53

Synthesis and antimicrobial activity of novel spirocompounds with pyrazolone and pyrazolthione moiety

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIAZA 2,4 DIPHENYL 8 OXO 1 THIOSPIRO[5.4]DEC 3 ENE; 2,3 DIAZA 4 METHYL 8 OXO 2 PHENYL 1 THIOSPIRO[5.4]DEC 3 ENE; CYCLOHEXANONE DERIVATIVE; GENTAMICIN; PYRAZOLONE; SPIRO COMPOUND; SULFADIAZINE SILVER; SULFUR DERIVATIVE; UNCLASSIFIED DRUG;

EID: 36749100787     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570440108     Document Type: Article
Times cited : (153)

References (29)
  • 26
    • 85036958749 scopus 로고    scopus 로고
    • Chem. Abstr., 55, 54244 (1961);
    • Chem. Abstr., 55, 54244 (1961);
  • 28
    • 85036989106 scopus 로고    scopus 로고
    • Chem. Abstr., 60, 3143 (1964).
    • Chem. Abstr., 60, 3143 (1964).
  • 29
    • 85036998532 scopus 로고    scopus 로고
    • Note: When the reaction conditions were altered by replacing sodamide/DMF with TEA/C2H5OH the diadduct was isolated in one of the reactions. Thus for example, 1c (0.01 mol, 3 (0.02 mol) and triethylamine (0.02 mol) in ethanol (20 ml) were refluxed for 12 hrs. The reaction mixture was poured onto 20 g crushed ice and acidified with 5 ml of 15% dil HCl. The oil, which separated, was extracted in ethyl acetate. The organic phase was washed well with water, brine and dried over sodium sulphate. Removal of organic solvent afforded a brown oil, which on column chromatography gave the diadduct 9c in 45% yield. The IR spectrum displayed the characteristic peak at 2245 cm-1. 1H-NMR (500 MHz, CDCl3, δ 2.33 (s, 3H, CH3, 2.48 (t, 4H, 2 x -CH 2-CN, J, 7.5 Hz, 2.79 (t, 4H, 2 x -CH 2-CH2, J, 7.5 Hz) and 7.40, 7.57 m,5H, phenyl protons
    • 3) δ 13.21, 17.58, 17.87, 29.20, 30.32, 108.96, 117.09, 124.71, 127.57, 128.53, 131.55, 149.25, 152.47 ppm. (Chemical Equation Presented)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.