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Volumn 7, Issue 14, 2005, Pages 3049-3052

Ionic liquid as catalyst and reaction medium. The dramatic influence of a task-specific ionic liquid, [bmIm]OH, in Michael addition of active methylene compounds to conjugated ketones, carboxylic esters, and nitriles

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EID: 22244486653     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol051004h     Document Type: Article
Times cited : (542)

References (49)
  • 5
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    • (e) Yao, Q. Org. Lett. 2002, 4, 2197.
    • (2002) Org. Lett. , vol.4 , pp. 2197
    • Yao, Q.1
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    • 0003417469 scopus 로고
    • Trost, B. M., Fleming, I., Semmelhack, M. F., Eds.; Pergamon: Oxford
    • (b) Jung, M. E. In Comprehensive Organic Synthesis; Trost, B. M., Fleming, I., Semmelhack, M. F., Eds.; Pergamon: Oxford, 1991; Vol. 4.
    • (1991) Comprehensive Organic Synthesis , vol.4
    • Jung, M.E.1
  • 40
    • 32744467830 scopus 로고    scopus 로고
    • note
    • + - OH) 139.2182, found 139.2355.
  • 41
    • 32744476374 scopus 로고    scopus 로고
    • note
    • 9b The ionic liquid left in the reaction vessel was rinsed with ether (2 mL) and dried under vacuum at 90°C for 2 h to eliminate any water trapped from moisture and reused for subsequent reactions. To compensate for the loss of some ionic liquid during washing, an amount (200 mg) of fresh ionic liquid was added after five runs. This procedure was followed for all the reactions listed in Table 1. However, in bis-additions, 2 equiv of methyl acrylate and acrylonitrile was used.


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