Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients - A pilot study

Nephrology Dialysis Transplantation

Volumn 22, Issue 12, 2007, Pages 3561-3567

  Saifullah, Akber ^a   Watkins, Bruce A ^b   Saha, Chandan ^a   Li, Yong ^b   Moe, Sharon M ^a,c   Friedman, Allon N ^a,d  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c RICHARD L ROUDEBUSH VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Department of Medicine ^*  (United States)

Author keywords

C reactive protein; Fish oil; Haemodialysis; n 3; Omega 3; Triglyceride

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL;

ADULT; ANALYTIC METHOD; ARTICLE; BURPING; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG TOLERANCE; ERYTHROCYTE; FEMALE; GASTROINTESTINAL SYMPTOM; HEART PROTECTION; HEMODIALYSIS; HUMAN; MALE; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

C-REACTIVE PROTEIN; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; FEMALE; FISH OILS; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; RENAL DIALYSIS;

EID: 36749089036     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm422     Document Type: Article

References (22)

1. Friedman A, Moe S. Review of the effects of omega-3 supplementation in dialysis patients. Clin J Am Soc Nephrol 2006; 47: 1064-1071
2. Friedman A, Moe S, Perkins S, Li Y, Watkins B. Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis. Am J Kidney Dis 2006; 47: 1064-1071
3. Schmitz PG, McCloud LK, Reikes ST, Leonard CL, Gellens ME. Prophylaxis of hemodialysis graft thrombosis with fish oil: double-blind, randomized, prospective trial. J Am Soc Nephrol 2002; 13: 184-190
4. Appel LJ, Miller ER, III, Seidler AJ, Whelton PK. Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 1993; 153: 1429-1438
5. Phillipson BE, Rothrock DW, Connor WE, Harris WS, Illingworth DR. Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med 1985; 312: 1210-1216
6. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447-455
7. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002; 106: 2747-2757
8. Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits. Am J Clin Nutr 2006; 83 [Suppl 6]: 1526S-1535S
9. Department of Health and Human Services. Substances affirmed as generally recognized as safe: menhaden oil: US Food and Drug Administration 5 June 1997. Report No.: 21 CRF Pt 184
10. K/DOQI Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients. Am J Kidney Dis 2005; 45 [Suppl 3]: S91-S94
11. Watkins BA, Li Y, Allen KG, Hoffmann WE, Seifert MF. Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats. J Nutr 2000; 130: 2274-2284
12. Donadio J, Bergstralh E, Offord K, Spencer D, Holley K. Group for the Mayo Nephrology Collaborative Group. A controlled trial of fish oil in IgA Nephropathy. N Engl J Med 1994; 331: 1194-1199
13. Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 2006; 83 [Suppl 6]: 1467S-1476S
14. Harris W, von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med 2004; 39: 212-220
15. Harris WS, Sands SA, Windsor SL et al. Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. Circulation 2004; 110: 1645-1649
16. Yeun J, Levine R, Mantadilok V, Kaysen G. C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2000; 35: 469-476
17. LaClair R, Wolisi G, Laberrere C, O'neill K, Sosa M, Moe S. Hemodialysis access type does not substantially impact inflammatory markers. J Am Soc Nephrol [abstract] 2005:PUB404
18. Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 2006; 189: 19-30
19. Lee TH, Hoover RL, Williams JD et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 1985; 312: 1217-1224
20. Shah B, Nair S, Sirsat RA, Ashavaid TF, Nair KG. Dyslipidemia in patients with chronic renal failure and in renal transplant patients. J Postgrad Med 1994; 40: 57-60
21. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 1998; 81: 7B-12B
22. Davidson MH. Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. Am J Cardiol 2006; 98: 27i-33i